The look of the con: Eleven thoughts on the historical absence of subtitles in film analysis

This article considers the lack of dialogue between Audio-Visual Translation and Film & Media Studies, despite the fact that both disciplines clearly have shared interests in the content of audio-visual texts. The apparent lack of any developed and consistent overlap between these areas of study is the starting point for a series of eleven ‘thoughts' that identify commonalities and differences in how film and television texts might be studied and analysed. Inspired and led by the specific example of a scene from Ocean’s Eleven (2001), the article explores the potential for interdisciplinary research collaborations through ideas of authorship, genre, history, technology, industry labour, and reception and audience studies. While identifying areas where different theories might clash or complicate collaboration, the article also highlights potent areas where shared experience and different perspectives could enrich both fields

Long-Lived Plasma Cells and Memory B Cells Produce Pathogenic Anti-GAD65 Autoantibodies in Stiff Person Syndrome

Stiff person syndrome (SPS) is a rare, neurological disorder characterized by sudden cramps and spasms. High titers of enzyme-inhibiting IgG autoantibodies against the 65 kD isoform of glutamic acid decarboxylase (GAD65) are a hallmark of SPS, implicating an autoimmune component in the pathology of the syndrome. Studying the B cell compartment and the anti-GAD65 B cell response in two monozygotic twins suffering from SPS, who were treated with the B cell-depleting monoclonal anti-CD20 antibody rituximab, we found that the humoral autoimmune response in SPS is composed of a rituximab-sensitive part that is rapidly cleared after treatment, and a rituximab-resistant component, which persists and acts as a reservoir for autoantibodies inhibiting GAD65 enzyme activity. Our data show that these potentially pathogenic anti-GAD65 autoantibodies are secreted by long-lived plasma cells, which may either be persistent or develop from rituximab-resistant memory B lymphocytes. Both subsets represent only a fraction of anti-GAD65 autoantibody secreting cells. Therefore, the identification and targeting of this compartment is a key factor for successful treatment planning of SPS and of similar autoimmune diseases

Strengthening or restricting? Explaining the Covid-19 pandemic's configurational effects on companies' sustainability strategies and practices

We explore the Covid-19 pandemic's impact on companies' sustainability strategies and practices. Prior research has identified a number of factors that shape such effects, including crisis severity, resource slack, and prior investments, but their interactions have not been given much attention. We thus collected qualitative data on 25 companies in four African countries, which we analysed inductively and iteratively through cross-case comparison and with fuzzy set Qualitative Comparative Analysis. We identify two pathways associated with strengthening responses ("building on strengths" and "governance gap-filling") and three associated with restricting responses ("hard hit," "low-road business-as-usual," and "bunkering down"). Our findings enhance our understanding of organisational responses to crises by attending to configurational effects and by foregrounding the role of governance contexts. We describe implications for future research and for managers, investors, and sustainability initiatives such as the United Nations Global Compact