Education and post-communist transitional justice: negotiating the communist past in a memorial museum

This paper examines the role of education within post-communist transitional justice. It focuses on the ways in which young Romanians negotiate the communist past during an educational visit to a memorial museum. The museum enabled these visitors to better understand the repression of the communist era, had limited impact in changing their attitudes towards communism, but it did provoke reflection upon and comparison between the present and the communist past. Visitors recognized the role of the museum as a site of memory within post-communist transitional justice, but were also critically aware of the limitations to what the museum could achieve. The implications of these findings for postcommunist transitional justice are examined

The Complex Role of the ZNF224 Transcription Factor in Cancer

ZNF224 is a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family. It was originally identified as a transcriptional repressor involved in gene-specific silencing through the recruitment of the corepressor KAP1, chromatin-modifying activities, and the arginine methyltransferase PRMT5 on the promoter of its target genes.Recent findings indicate that ZNF224 can behave both as a tumor suppressor or an oncogene in different human cancers. The transcriptional regulatory properties of ZNF224 in these systems appear to be complex and influenced by specific sets of interactors. ZNF224 can also act as a transcription cofactor for other DNA-binding proteins. A role for ZNF224 in transcriptional activation has also emerged.Here, we review the state of the literature supporting both roles of ZNF224 in cancer. We also examine the functional activity of ZNF224 as a transcription factor and the influence of protein partners on its dual behavior.Increasing information on the mechanism through which ZNF224 can operate could lead to the identification of agents capable of modulating ZNF224 function, thus potentially paving the way to new therapeutic strategies for treatment of cancer