Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing

Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in advance of human clinical trials. Based on this experience, the following review was undertaken to identify (1) regulatory and scientific drivers for acute toxicity testing in other industrial sectors, (2) activities aimed at replacing, reducing, or refining the use of animals, and (3) recommendations for future work in this area

Hair analysis for detection of triptans occasionally used or overused by migraine patients-a pilot study

Purpose The aim of this study is to evaluate the detection rate of almotriptan, eletriptan, frovatriptan, sumatriptan, rizatriptan, and zolmitriptan in the hair of migraineurs taking these drugs; the degree of agreement between type of self-reported triptan and triptan found in hair; if the concentrations in hair were related to the reported cumulative doses of triptans; and whether hair analysis was able to distinguish occasional use from the overuse of these drugs. Methods Out of 300 headache patients consecutively enrolled, we included 147 migraine patients who reported to have taken at least one dose of one triptan in the previous 3 months; 51 % of the patients overused triptans. A detailed pharmacological history and a sample of hair were collected for each patient. Hair samples were analyzed by liquid chromatography-electrospray tandem mass spectrometry (LC-MS/MS) by a method that we developed. Results All the triptans could be detected in the hair of the patients. The agreement between type of self-reported triptan and type of triptan found in hair was from fair to good for frovatriptan and zolmitriptan and excellent for almotriptan, eletriptan, sumatriptan, and rizatriptan (P < 0.01, Cohen’s kappa). The correlation between the reported quantities of triptan and hair concentrations was statistically significant for almotriptan, eletriptan, rizatriptan, and sumatriptan (P < 0.01, Spearman’ s rank correlation coefficient). The accuracy of hair analysis in distinguishing occasionally users from overusers was high for almotriptan (ROC AUC = 0.9092), eletriptan (ROC AUC = 0.8721), rizatriptan (ROC AUC = 0.9724), and sumatriptan (ROC AUC = 0.9583). Conclusions Hair analysis can be a valuable system to discriminate occasional use from triptan overuse

Energy and carbon audit of a rooftop wind turbine

Abstract: Microgeneration is being promoted as a means of lowering carbon dioxide (CO2) emissions by replacing electricity from the grid with production from small domestic genera-tors. One concern over this drive is that the use of smaller plant could lead to the loss of econ-omies of scale. Partly, this relates to cost but also in terms of energy consumed and CO2 emitted over the life cycle of the microgenerator. Here, an analysis is presented of a life-cycle audit of the energy use and CO2 emissions for the ‘SWIFT’, a 1.5 kW rooftop-mounted, grid-connected wind turbine. The analysis shows that per kilowatt-hour of electricity generated by the turbine, the energy intensity and CO2 emissions are comparable with larger wind turbines and significantly lower than fossil-fuelled generation. With energy and carbon intensities sensitive to assumed levels of production, assessments were carried out for an annual production range of 1000–4000 kWh, representing capacity factors of 8–31 per cent. For the manufacturer’s estimated production of 2000 to 3000 kWh and, giving credit for component recycling, the energy payback period was found to be between 17 and 25 months, whereas the CO2 payback was between 13 and 20 months. Across the full production range, the energy and carbon payback periods were 13–50 months and 10–39 months, respectively. A key outcome of the study is to inform the manufacturer of the opportunities for improving the energy and carbon intensities of the turbine. A simple example is presented showing the impact of replacing one of the larger aluminium components with alternative materials

Sustainable Construction Technologies: Life Cycle Assessment.

The building and construction industry has become the focus of environmental impact reduction in the aftermath of the global resolution to reduce its adverse effect and make the built environment more sustainable. This chapter examines the place of materials in sustainable building construction generally and from the perspective of life cycle assessment and reduction of environmental impact. Hence, specific approaches to sustainable construction from the perspective of materials such as improved material production processes, recycling, materials substitution, innovative construction methods, deconstruction, use of innovative materials, and use of eco-friendly materials are explained from the life cycle impact perspective. The implications of the approaches for improved uptake of sustainable construction practices are also examined with particular reference to the role of policy framework and legislatio

Integration of the environmental management aspect in the optimization of the design and planning of energy systems

The increasing concerns regarding the environmental pollution derived from anthropogenic activities, such as the use of fossil fuels for power generation, has driven many interested parties to seek different alternatives, e.g. use of renewable energy sources, use of “cleaner” fuels and use of more effective technologies, in order to minimize and control the quantity of emissions that are produced during the life cycle of conventional energy sources. In addition to these alternatives, the use of an integrated procedure in which the environmental aspect will be taken into account during the design and planning of energy systems could provide a basis on which emissions reduction will be dealt with a life cycle approach. The work presented in this paper focuses on the examination of the possibilities of integrating the environmental aspects in the preliminary phase of the conventional design and planning of energy systems in conjunction with other parameters, such as financial cost, availability, capacity, location, etc. The integration of the environmental parameter to the design is carried out within a context where Eco-design concepts are applied. Due to the multi-parameter nature of the design procedure, the tools that are used are Life Cycle Analysis and Multi-criteria Analysis. The proposed optimization model examines and identifies optimum available options of the use of different energy sources and technologies for the production of electricity and/or heat by minimizing both the financial cost and the environmental impacts, with regard to a multiple objective optimization subject to a set of specific constraints. Implementation of the proposed model in the form of a case study for the island of Rhodes in Greece revealed that an optimized solution both cost and environmental-wise, would be an almost balanced participation of renewables and non-renewable energy sources in the energy mix