A forward solution for RF impedance tomography in wood

Both integral equation and differential equation methods enable modelling current and hence impedance of wood, to provide the forward solution for impedance tomography that in turn provides a measure of its internal moisture distribution. Previously, we have used a series impedance model and successfully demonstrated measurement of internal moisture distribution. Here we describe the adaptation of our integral equation method for this application. This has required an alternative calculation to model the impressed field from the segmented electrodes used in the measurements to date, and we demonstrate distortion of the anomalous field due to the presence of a wood dielectric, and the field magnitude. Further work will be required to translate the resulting field distribution from our model, to complex current and hence impedance readings, to allow completion of tomographic reconstruction using this approach

Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation

AbstractThe podosome and invadopodium are dynamic cell-adhesion structures that degrade the extracellular matrix (ECM) and promote cell invasion. We recently reported that the actin-binding protein caldesmon is a pivotal regulator of podosome formation. Here, we analyzed the caldesmon’s involvement in podosome/invadopodium-mediated invasion by transformed and cancer cells. The ectopic expression of caldesmon reduced the number of podosomes/invadopodia and decreased the ECM degradation activity, resulting in the suppression of cell invasion. Conversely, the depletion of caldesmon facilitated the formation of podosomes/invadopodia and cell invasion. Taken together, our results indicate that caldesmon acts as a potent repressor of cancer cell invasion