La narrativa transmedial en prácticas de enseñanza universitarias ¿una propuesta para la formación en Profesorados?

Hacer investigación a partir de las problemáticas de la formación docente inicial, en los profesorados universitarios, es abordar un vasto campo de conocimientos vinculado a tradiciones de distintos órdenes: epistémicas, pedagógicas, didácticas, psicológicas, políticas, presupuestarias entre otras. La formación de docentes en el devenir histórico social de la Argentina, muestra diferentes trayectorias, modalidades y políticas de formación respecto a la docencia

La narrativa transmedial en contenidos de la formación docente inicial

Hacer investigación a partir de las problemáticas de la formación docente inicial, es entrar en un vasto campo de conocimientos vinculado con tradiciones de distintos órdenes: epistémicas, pedagógicas, didácticas, psicológicas, políticas, presupuestarias entre otras. La formación de docentes en el devenir histórico social de la Argentina, muestra diferentes trayectorias, modalidades y políticas de formación respecto a la docencia. Acorde a este posicionamiento es relevante considerarla, no solo desde un aquí y ahora, sino también en su devenir histórico social, donde pueden reconocerse tanto trayectorias y modalidades como políticas de formación respecto a la docencia, siendo posible identificar hoy una novedad, la interacción con narrativas transmediales (NT). Esto es una narración contada de distintas maneras a partir de diferentes medios y desde construcciones audiovisuales y/o escritas colaborativas. Los sujetos participantes de ese relato transmedial expanden el contenido en nuevas/otras escenas o situaciones. Estas narrativas son propuestas en Argentina por los medios de comunicación del Ministerio de Educación Nacional, ahora dispuestos como herramientas para la enseñanza formal. Un estudio exploratorio de esas narrativas transmediales ha sido realizado, en el marco de una perspectiva cualitativa de investigación a partir de un programa de Canal Encuentro, que aborda temas de la formación docente inicial. La tarea realizada permitió identificar contenidos del campo de la formación general, en/desde propuestas transmediales. Los resultados permiten afirmar que la reorganización de los contenidos de la formación docente inicial a través de las NT, propondrían una gramática distinta a los trayectos formativos. Estos nuevos formatos de comunicar contenidos disciplinares no sólo denotan nuevas herramientas culturales, sino que además ponen en escena las prácticas educativas, en tanto prácticas sociales, visibilizando que no están aisladas del contexto socio cultural global. Además, estudiar y analizar los medios de comunicación de la educación en el marco de la convergencia tecnológica, situada en el ámbito de la educación formal, es comprender un contexto que indica que el siglo XXI se caracteriza por brindar diversas propuestas de tecnología educativa.Fil: Sobrino, Mónica. Universidad Nacional del Comahue. Facultad de Ciencias de la Educación. Departamento de Didáctica; Argentina

Adapting RRI public engagement indicators to the Spanish scientific and innovation context: a participatory methodology based on AHP and content analysis

The paradigm proposed by Responsible Research and Innovation in the European Commission policy discourse identifies Public Engagement as a key area for exchange and dialogue among multiple actors following an inclusive and participatory process. Two definite set of indicators have already arisen at European level to monitor Public Engagement activities in the Science and Innovation realm. Our study aims to propose a deliberative participatory process, which involves selected stakeholders, for the adaptation of the European indicators to the specific Spanish scientific and innovation context. The methodological procedure is of exploratory nature and will be based in a combination of, on the one hand, qualitative content analysis techniques for the in-depth study of the deliberative process and the generation of indicators; and, on the other hand, a multi-criteria decision analysis technique such as the Analytic Hierarchy Process for the prioritization of the indicators. The discussion will focus on the procedure to articulate stakeholders' values and use them as the basis for creating a context-based improved list of indicators. Two types of research questions arise: (i) Is the proposed methodology adequate for the adaptation of the European indicators to the Spanish context? (ii) What are the main indicators to monitor and to expand reflection on the public engagement in the Spanish science and innovation

Closing the gender gap at academic conferences: A tool for monitoring and assessing academic events

The importance of participation in academic conferences is well known for members of the scientific community. It is not only for the feedback and the improvement of the work, it is also about career development, building networks and increasing visibility. Nevertheless, women continue to be under-represented in these academic events and even more so in the most visible positions such as speaking roles. This paper presents the development of a tool based on performance indicators, which will allow monitoring and evaluating gender roles and inequalities in academic conferences in order to tackle the underrepresentation of women. The study identifies relevant perspectives (participation, organizational structure and attitudes) and designs specific lists of performance indicators for each of them. The tool is based on a combination of two multicriteria techniques, Analytic Hierarchy Process and Analytic Hierarchy Process Sort, and a qualitative analysis based on in-depth interviews and information gathered from a focus group. The use of the AHP multi-criteria decision technique has allowed us to weight the indicators according to the opinion of several experts, and with them to be able to generate from these weightings composite indicators for each of the three dimensions. The most relevant indicators were for the participation dimension. Additionally, the tool developed has been applied to an academic conference which has been monitored in real time. The results are shown as a traffic light visualization approach, where red means bad performance, yellow average performance and green good performance, helping us to present the results for each indicator. Finally, proposals for improvement actions addressed to the red indicators are explained. The work carried out highlights the need to broaden the study of gender equality in academic conferences, not only regarding the participation but also the performance of different roles and functions.Grant Number OR2019-60221 Funder: Open Society Foundations Programme: Open Society Initiative for Europe Award: Expanding the Female Talent Pipeline in Europe https://www.opensocietyfoundations.org

Effects of a Novel Nutraceutical Combination (Aquilea Colesterol®) on the Lipid Profile and Inflammatory Biomarkers: A Randomized Control Trial

Background: Cholesterol-lowering nutraceuticals are useful in the management of moderate hypercholesterolemia. Methods: In a parallel-group, randomized, placebo-controlled double-blind trial we evaluated the effects on plasma total cholesterol, low-density lipoprotein cholesterol (LDL-c), and inflammatory biomarkers of a nutraceutical combination (Aquilea Colesterol®) containing phytosterols (1.5 g), red yeast rice providing monacolin K (10 mg), hydroxytyrosol (5 mg), and plasma cholesterol values >5.17 mmol/L (>200 mg/dL) and LDL-c >2.97 mmol/L (>115 mg/dL). At baseline and at one and three months we recorded dietary habits; anthropometric parameters; blood pressure; lipid profile; fasting glucose; liver, renal, and muscle function tests, C-reactive protein (hs-CRP); and interleukin-6. Results: 13 men and 27 women (mean age 61.8 years) completed the trial; 20 participants received the nutraceutical and 20 received placebo. No adverse effects were noted. Compared to placebo, at one and three months the nutraceutical reduced total cholesterol by 11.4% and 14.1%, LDL-c by 19.8% and 19.7%, and apolipoprotein B by 12.4% and 13.5%, respectively (p < 0.001; all). hs-CRP decreased significantly (p = 0.021) in the nutraceutical group. Conclusion: The nutraceutical Aquilea Colesterol® is useful for reducing total cholesterol, LDL-c, and inflammation in individuals with moderate hypercholesterolemia

The crystal structure of galactitol-1-phosphate 5-dehydrogenase from Escherichia coli K12 provides insights into its anomalous behavior on IMAC processes

AbstractEndogenous galactitol-1-phosphate 5-dehydrogenase (GPDH) (EC 1.1.1.251) from Escherichia coli spontaneously interacts with Ni2+-NTA matrices becoming a potential contaminant for recombinant, target His-tagged proteins. Purified recombinant, untagged GPDH (rGPDH) converted galactitol into tagatose, and d-tagatose-6-phosphate into galactitol-1-phosphate, in a Zn2+- and NAD(H)-dependent manner and readily crystallized what has permitted to solve its crystal structure. In contrast, N-terminally His-tagged GPDH was marginally stable and readily aggregated. The structure of rGPDH revealed metal-binding sites characteristic from the medium-chain dehydrogenase/reductase protein superfamily which may explain its ability to interact with immobilized metals. The structure also provides clues on the harmful effects of the N-terminal His-tag.Structured summary of protein interactionsGPDH and GPDH bind by molecular sieving (View interaction)GPDH and GPDH bind by x-ray crystallography(View interaction)GPDH and GPDH bind by cosedimentation in solution (View interaction

Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke.

BACKGROUND: Neuroserpin has shown neuroprotective effects in animal models of cerebral ischemia and has been associated with functional outcome after ischemic stroke. Our aim was to study whether neuroserpin serum levels could be associated to biomarkers of excitotoxicity, inflammation and blood brain barrier disruption. METHODS: We prospectively included 129 patients with ischemic stroke (58.1% male; mean age, 72.4 ± 9.6 years) not treated with tPA within 12 hours (h) of symptoms onset (mean time, 4.7 ± 2.1 h). Poor functional outcome at 3 months was considered as a modified Rankin scale score >2. Serum levels of neuroserpin, Interleukin 6 (IL-6), Intercellular adhesion molecule-1 (ICAM-1), active Matrix metalloproteinase 9 (MMP-9), and cellular fibronectin (cFn) (determined by ELISA) and glutamate (determined by HPLC) were measured on admission, 24 and 72 h. The main variable was considered the decrease of neuroserpin levels within the first 24 h. ROC analysis was used to select the best predictive value for neuroserpin to predict poor functional outcome due to a lack of linearity. RESULTS: The decrease of neuroserpin levels within the first 24 h was negatively correlated with serum levels at 24 hours of glutamate (r = -0.642), IL-6 (r = -0.678), ICAM-1 (r = -0.345), MMP-9 (r = -0.554) and cFn (r = -0.703) (all P < 0.0001). In the multivariate analysis, serum levels of glutamate (OR, 1.04; CI95%, 1.01-1.06, p = 0.001); IL-6 (OR, 1.4; CI95%, 1.1-1.7, p = 0.001); and cFn (OR, 1.3; CI95%, 1.1-1.6, p = 0.002) were independently associated with a decrease of neuroserpin levels <70 ng/mL at 24 h after adjusting for confounding factors. CONCLUSIONS: These findings suggest that neuroprotective properties of neuroserpin may be related to the inhibition of excitotoxicity, inflammation, as well as blood brain barrier disruption that occur after acute ischemic stroke

Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Pluripotent stem cell-derived cardiomyocytes (CMs) have great potential in the development of new therapies for cardiovascular disease. In particular, human induced pluripotent stem cells (iPSCs) may prove especially advantageous due to their pluripotency, their self-renewal potential, and their ability to create patient-specific cell lines. Unfortunately, pluripotent stem cell-derived CMs are immature, with characteristics more closely resembling fetal CMs than adult CMs, and this immaturity has limited their use in drug screening and cell-based therapies. Extracellular matrix (ECM) influences cellular behavior and maturation, as does the geometry of the environment—twodimensional (2D) versus three-dimensional (3D). We therefore tested the hypothesis that native cardiac ECM and 3D cultures might enhance the maturation of iPSC-derived CMs in vitro. We demonstrate that maturation of iPSCderived CMs was enhanced when cells were seeded into a 3D cardiac ECM scaffold, compared with 2D culture. 3D cardiac ECMpromoted increased expression of calcium-handling genes, Junctin, CaV1.2, NCX1, HCN4, SERCA2a, Triadin, and CASQ2. Consistent with this, we find that iPSC-derived CMs in 3D adult cardiac ECM show increased calcium signaling (amplitude) and kinetics (maximum upstroke and downstroke) compared with cells in 2D. Cells in 3D culture were also more responsive to caffeine, likely reflecting an increased availability of calcium in the sarcoplasmic reticulum. Taken together, these studies provide novel strategies for maturing iPSC-derived CMs that may have applications in drug screening and transplantation therapies to treat heart disease

Association of High Serum Levels of Growth Factors with Good Outcome in Ischemic Stroke : a Multicenter Study

Altres ajuts: This project was partially supported by grants from Xunta de Galicia (Consellería Educación: GRC2014/027 and IN607A2018/3), Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS PLUS (RD16/0019), and by the European Union FEDER program.The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1α with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with non-lacunar stroke (male, 62.1%; mean age, 68.2 ± 11.4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] ≤ 2) at 12 months. Secondary outcome variable was infarct volume (in mL) after 6 ± 3 months. Serum levels of VEGF, Ang-1, G-CSF, BDNF, and SDF-1α were measured by ELISA at admission, 7 ± 1 days, at 3 ± 1 months, and 12 ± 3 months. Except for BDNF, all GF and SDF-1α serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all p < 0.01). High serum levels at day 7 of VEGF (OR, 19.3), Ang-1 (OR, 14.7), G-CSF (OR, 9.6), and SDF-1α (OR, 28.5) were independently associated with good outcome at 12 months (all p < 0.0001). On the other hand, serum levels of VEGF (B, − 21.4), G-CSF (B, − 14.0), Ang-1 (B, − 13.3), and SDF-1α (B, − 44.6) measured at day 7 were independently associated with lesion volume at 6 months (p < 0.01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1α at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smaller residual lesion at 1 year of follow-up

Las prácticas en el programa de Licenciatura en Pedagogía Infantil: una experiencia formativa

Una mirada a la práctica: su razón de ser en el Programa de Licenciatura en Pedagogía Infantil -- La investigación en la práctica: alianza necesaria en la formación inicial del maestro -- Una apuesta por la organización de la práctica -- Una construcción que partió desde los orígenes del programa -- Vivencia y convicciones sobre su rol de profesional