Modern approaches to parodontitis therapy in HIV patients

The research goal is to determine the clinical pathogenetic efficacy of Cycloferon liniment in the combined therapy of periodontitis in patients with subclinical stage of HIV-infection. Medical examination and treatment of 40 patients has been carried out. It is established that use of liniment Cycloferon in the combined treatment of patients with subclinical stage of HIV-infection allows to accelerate process of normalization of lipid peroxidation parameters and antioxidant potential of blood and to decrease infection (herpes symplex virus I, Candida albicans, staphylococcus aureus) in par-odontal recess and evidence of local inflammation. The considered method of therapy has been proved to improve convalescence period and to decrease frequency of parodontitis recurrence

Periodontitis in HIV patients

The article presents the study of formation mechanisms and periodontitis course in patients with subclinical stage of HIV-infection. The examination of 45 patients has enabled the division of patients into three basic groups: patients with periodontitis and HIV-infection; patients with periodontitis; and HIV patients without periodontitis. It has been determined that the patients with periodontitis and subclinical HIV-infection have developed local inflammatory reaction with infection, activation of anti-inflammatory cytokines in parodontal recess fluid. It has been proved that the causative factor of frequent and durable relapses in parodontal pathology with clinical HIV-infection was the development of pathologic process with endotoxicosis syndrome and imbalance of lipid peroxidation and antioxidant syste

РЕЗУЛЬТАТЫ И ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ ИНДУКТОРОВ ИНТЕРФЕРОНА В ЛЕЧЕНИИ ИНФЕКЦИОННЫХ БОЛЕЗНЕЙ

There is represented  the current classification of interferon inducers of various chemical groups related to antiviral agents, described the mechanisms of synthesis of different types of endogenous interferon in blood serum. The effectiveness of methylglucamine acridonacetates  in integrated treatment of chronic hepatitis C, tuberculosis with  HIV infection background, chronic brucellosis, arboviral diseases, including West Nile fever , as well as influenza and acute respiratory infections are shown.  For successful treatment of acute and chronic diseases with  endogenous interferon inducers should be applied as early as possible, at an average level of viremia , to enhance the effect of drugs with the directed etiotropic action and immunomodulators , which achieves the optimal pharmacotherapeutic effect.Представлена современная  классификация  индукторов  интерферона различных химических групп, относящихся к противовирусным средствам, описаны механизмы синтеза разных типов эндогенного интерферона в сыворотке крови. Продемонстрирована эффективность метилглукамина акридонацетата в комплексном лечении хронического гепатита С, туберкулеза на фоне ВИЧ-инфекции, хронического бруцеллеза, арбовирусных заболеваний, включая лихорадку Западного Нила, а также гриппа и острых респираторных инфекций. Для успешного лечения острых и хронических заболеваний индукторы эндогенного интерферона следует применять как можно раньше, при среднем уровне  виремии,  для усиления эффекта  препаратов  направленного этиотропного действия и иммуномодуляторов, что обеспечивает  достижение оптимального фармакотерапевтического эффекта.

New approaches to therapy of oral inflammatory diseases

The purpose of the work is to prescribe combined treatment in order to determine the efficiency of cycloferon liniment. Materials and methods. 80 patients suffering from such inflammatory disease of parodentium as herpetic stomatitis and periodontitis have been examined and treated. Results. Cycloferon liniment used in the combined treatment of stomatitis and periodontitis reduces the infection load in gingival pockets, decreases local inflammation, normalizes immunity parameters, decreases endotoxemia and reduces relapse rates. Conclusion. Cycloferon liniment is an efficient medication restoring the parameters of local nonspecific immune response

Оptimization of periodontitis treatment in patients with chronic brucellosis infection

For the purpose to determine the clinical pathogenetic efficacy of Cycloferon liniment in the combined therapy of parodontitis in patients with chronic brucellosis medical examination and treatment of 50 patients was carried out. It was established that use of liniment Cycloferon in the combined treatment of patients with pariodontitis against chronic brucellosis allowed to accelerate process of normalization of parameters of lipid peroxidation and antioxidant potential of blood, to decrease infection load (herpes symplex virus I, candida albicans, staphylococcus aureus) in parodontal recess and evidence of local inflammation with reduction of activity of tumour necrosis and interleukin 1b, that provided acceleration of recovery processes, lowering in frequency of pariodontitis recurrence

Clinical and pathogenetic approaches to development of parodontitis therapy in patients with chronic hepatitis С

The research goal in to determine clinical and pathogenetic efficacy of Cycloferon liniment in the combined therapy of parodontitis in patients with chronic hepatitis C. Examination and treatment of 50 patients were conducted. It was revealed that the use of Cycloferon liniment in the combined treatment of patients with parodontitis accompanied by chronic hepatitis C allowed to accelerate process of normalization of lipid peroxidation and antioxidant potential of blood, to decrease infectious inflammation (herpes simplex virus I, candida albicans, staphylococcus aureus) in parodontal recess and local inflammation. The described method of treatment provided process of recovery and decrease in frequency of parodontitis recurrence

CHILDREN'S ARTERIAL HYPERTENSION: DRUG CHOICE. THE RESULTS OF THE PHARMACOEPIDEMIOLOGICAL STUDY RIFAGD

The multicentered pharmacoepidemiological study «Rifagd» (prevalence and pharmacotherapy of arterial hypertension in children) in 13 cities of Russia was conducted with the purpose of analyzing of pediatricians' approach to the treatment of children's arterial hypertension, including drug choice. This allowed to estimate their experience, knowledge, as well as to direct the way to improvements of quality in medical treatment of patients with arterial hypertension. The majority of pediatricians (83,1%) encounter difficulties in hypertension treatment in connection with guidelines absence (37,3%), medical practice absence (30,4%) and «absence of indications for the application of antihypertensive drugs in pediatrics» (31,9%). for arterial hypertension treatment pediatricians use AgE-inhibitors, diuretics and beta blockers.Key words: rifagd, arterial hypertension, pharmacoepidemiology, questioning of pediatricians, ace inhibitors, diuretics, beta blockers

HYPERPIESIS OF CHILDREN AND TEENAGERS: REAL PROBLEM FOR A PEDIATRICIAN

The authors have conducted multicentric epidemiological research in 13 cities of russia to examine approaches of pediatricians to diagnostics and treatment hyperpiesis in childhood, which allowed the researchers to estimate their experience and knowledge. It has turned out that most pediatricians can not apply the knowledge in hyperpiesis diagnostics due to the absence of the agebdependent cuffs to measure hyperpiesis, as well as the skills to assess the hyperpiesis measurement findings along with centile tables use. Quality improvement of hyperpiesis diagnostics in childhood is possible by means of implementation of educational programs for the pediatricians on diagnostics and treatment of children, suffering from hyperpiesis.Key words: child's hyperpiesis, epidemiology, diagnostics, children

CHILDREN'S ARTERIAL HYPERTENSION: DRUG CHOICE. THE RESULTS OF THE PHARMACOEPIDEMIOLOGICAL STUDY RIFAGD

The multicentered pharmacoepidemiological study «Rifagd» (prevalence and pharmacotherapy of arterial hypertension in children) in 13 cities of Russia was conducted with the purpose of analyzing of pediatricians' approach to the treatment of children's arterial hypertension, including drug choice. This allowed to estimate their experience, knowledge, as well as to direct the way to improvements of quality in medical treatment of patients with arterial hypertension. The majority of pediatricians (83,1%) encounter difficulties in hypertension treatment in connection with guidelines absence (37,3%), medical practice absence (30,4%) and «absence of indications for the application of antihypertensive drugs in pediatrics» (31,9%). for arterial hypertension treatment pediatricians use AgE-inhibitors, diuretics and beta blockers.Key words: rifagd, arterial hypertension, pharmacoepidemiology, questioning of pediatricians, ace inhibitors, diuretics, beta blockers