Identification of the key investment project management factors in the housing construction sector in Poland

The aim of this paper is to distinguish a number of factors that allow for a better understanding of investment process management in the housing construction industry. The research work that we performed consisted in conducting a questionnaire survey. A total of 192 Polish companies dealing with housing construction took part in the survey. The collected questionnaire responses were then subjected to a thorough analysis and interpretation, with the use of a method called exploratory factor analysis (EFA). In a nutshell, our analysis consisted in reducing the number of survey variables (73) in order to identify a few pivotal factors (4) with the greatest impact on investment processes management in the field of residential construction in Poland. These factors include: the activity of companies in the market environment (1), pro-social policy of the state (2), highly advanced technologies (3) and the use of appropriate market relations (4). In our study, we aim to show how successful construction processes are perceived by industry professionals. The scientific method that we used allows for assignment of a certain order of priority to specific groups of questionnaire variables, dependent on the eigenvalues-related percentage of explained variation

The view of construction companies' managers on the impact of economic, environmental and legal policies on investment process management

This article discusses the impact of economic, environmental and legal policies on management of the companies involved in investment projects in the area of industrial construction in Poland. Our empirical research relied on conducting a survey in a group of construction managers and experts. The survey involved 158 Polish companies from the SME sector dealing from the industrial construction. The questionnaire responses were thoroughly analysed and interpreted with the use of a method called exploratory factor analysis (EFA). The results provide an insight into successful management of investment processes realised by construction companies implementing projects in the area of industrial construction. The most important factors identified with the use of this research method turned out to be the availability of technology in a stable political system, stability of economic and tax systems, stable social policy, stability and transparency of the legal system and well-targeted environmental policies. In general, it can be stated that the effective management of industrial construction projects is influenced by the economic, environmental and legal policies of the state

Down-sampling of large lidar dataset in the context of off-road objects extraction

Nowadays, LiDAR (Light Detection and Ranging) is used in many fields, such as transportation. Thanks to the recent technological improvements, the current generation of LiDAR mapping instruments available on the market allows to acquire up to millions of three-dimensional (3D) points per second. On the one hand, such improvements allowed the development of LiDAR-based systems with increased productivity, enabling the quick acquisition of detailed 3D descriptions of the objects of interest. However, on the other hand, the extraction of the information of interest from such huge amount of acquired data can be quite challenging and time demanding. Motivated by such observation, this paper proposes the use of the Optimum Dataset method in order to ease and speed up the information extraction phase by significantly reducing the size of the acquired dataset while preserving (retain) the information of interest. This paper focuses on the data reduction of LiDAR datasets acquired on roads, with the goal of extraction the off-road objects. Mostly motivated by the need of mapping roads and quickly determining car position along a road, the development of efficient methods for the extraction of such kind of information is becoming a hot topic in the research community

How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges

Jan Sobieraj,* Katarzyna Strzelecka,* Marcin Sobczak, Ewa Oledzka Department of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, 02-097, Poland*These authors contributed equally to this workCorrespondence: Ewa Oledzka, Department of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, Warsaw, 02-097, Tel +48-22-572-07-55, Email [email protected]: Cannabinoids are compounds found in and derived from the Cannabis plants that have become increasingly recognised as significant modulating factors of physiological mechanisms and inflammatory reactions of the organism, thus inevitably affecting maintenance of homeostasis. Medical Cannabis popularity has surged since its legal regulation growing around the world. Numerous promising discoveries bring more data on cannabinoids’ pharmacological characteristics and therapeutic applications. Given the current surge in interest in the medical use of cannabinoids, there is an urgent need for an effective method of their administration. Surpassing low bioavailability, low water solubility, and instability became an important milestone in the advancement of cannabinoids in pharmaceutical applications. The numerous uses of cannabinoids in clinical practice remain restricted by limited administration alternatives, but there is hope when biodegradable polymers are taken into account. The primary objective of this review is to highlight the wide range of indications for which cannabinoids may be used, as well as the polymeric carriers that enhance their effectiveness. The current review described a wide range of therapeutic applications of cannabinoids, including pain management, neurological and sleep disorders, anxiety, and cancer treatment. The use of these compounds was further examined in the area of dermatology and cosmetology. Finally, with the use of biodegradable polymer-based drug delivery systems (DDSs), it was demonstrated that cannabinoids can be delivered specifically to the intended site while also improving the drug’s physicochemical properties, emphasizing their utility. Nevertheless, additional clinical trials on novel cannabinoids’ formulations are required, as their full spectrum therapeutical potential is yet to be unravelled. Keywords: cannabinoids, drug delivery systems, cannabidiol, tetrahydrocannabinol, biodegradable polymers, nanomedicin

Computational Polyethylene-Ceramic Composite Plate Design and Optimization

A composite designed Ultra High Molecular Weight Polyethylene (UHMWPE) reinforced by a material with a failure mode that will strengthen the system may significantly improve on modern armor designs. UHMWPE is considerably less dense than steel or high density ceramics. It is reasonable to consider making improvements to the weight-performance of armor by using the lower density UHMWPE and combining it with inserts of a high-density ceramic. A cellular ceramic encapsulated by rubber may significantly increase the amount of kinetic energy a composite will absorb through a phase transition. It is theorized that a series of ceramic inserts distributed in a polymer matrix will result in an increased impact resistance. Shock propagation in the ceramic will be minimal, and the elastomeric properties of the polymer will provide maximum tensile support. The ceramic inserts will act as a stress concentrator and physical resistor to the impacting object. When the ceramic inserts are shattered by the impactor they will impart a resistive force by forcing additional deformation in the polymer matrix. Study of design variations by examination of multiple geometries for the ceramic inserts will maximize the impact resistance of the structure. The resistance of the structure is enhanced by providing a multi-dimensional failure mode. The ceramic, once shattered, will still occupy space, forcing additional plastic deformation, and additional deformation in the impactor

Smart Tungsten-based Alloys for a First Wall of DEMO

During an accident with loss-of-coolant and air ingress in DEMO, the temperature of tungsten first wall cladding may exceed 1000 °C and remain for months leading to tungsten oxidation. The radioactive tungsten oxide can be mobilized to the environment at rates of 10–150 kg per hour. Smart tungsten-based alloys are under development to address this issue. Alloys are aimed to function as pure tungsten during regular plasma operation of DEMO. During an accident, alloying elements will create a protective layer, suppressing release of W oxide. Bulk smart alloys were developed by using mechanical alloying and field-assisted sintering technology. The mechanical alloying process was optimized leading to an increased powder production by at least 40 %. Smart alloys and tungsten were tested under a variety of DEMO-relevant plasma conditions. Both materials demonstrated similar sputtering resistance to deuterium plasma. Under accident conditions, alloys feature a 40-fold reduction of W release compared to that of pure tungsten.</p

Improved Biodistribution and Extended Serum Half-Life of a Bacteriophage Endolysin by Albumin Binding Domain Fusion

The increasing number of multidrug-resistant bacteria intensifies the need to develop new antimicrobial agents. Endolysins are bacteriophage-derived enzymes that degrade the bacterial cell wall and hold promise as a new class of highly specific and versatile antimicrobials. One major limitation to the therapeutic use of endolysins is their often short serum circulation half-life, mostly due to kidney excretion and lysosomal degradation. One strategy to increase the half-life of protein drugs is fusion to the albumin-binding domain (ABD). By high-affinity binding to serum albumin, ABD creates a complex with large hydrodynamic volume, reducing kidney excretion and lysosomal degradation. The aim of this study was to investigate the in vitro antibacterial activity and in vivo biodistribution and half-life of an engineered variant of the Staphylococcus aureus phage endolysin LysK. The ABD sequence was introduced at different positions within the enzyme, and lytic activity of each variant was determined in vitro and ex vivo in human serum. Half-life and biodistribution were assessed in vivo by intravenous injection of europium-labeled proteins into C57BL/6 wild-type mice. Our data demonstrates that fusion of the endolysin to ABD improves its serum circulation half-life and reduces its deposition in the kidneys in vivo. The most active construct reduced S. aureus counts in human serum ex vivo by 3 logs within 60 min. We conclude that ABD fusions provide an effective strategy to extend the half-life of antibacterial enzymes, supporting their therapeutic potential for treatment of systemic bacterial infections

Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection

The rising prevalence of antimicrobial resistance in S. aureus has rendered treatment of staphylococcal infections increasingly difficult, making the discovery of alternative treatment options a high priority. Peptidoglycan hydrolases, a diverse group of bacteriolytic enzymes, show high promise as such alternatives due to their rapid and specific lysis of bacterial cells, independent of antibiotic resistance profiles. However, using these enzymes for the systemic treatment of local infections, such as osteomyelitis foci, needs improvement, as the therapeutic distributes throughout the whole host, resulting in low concentrations at the actual infection site. In addition, the occurrence of intracellularly persisting bacteria can lead to relapsing infections. Here, we describe an approach using tissue-targeting to increase the local concentration of therapeutic enzymes in the infected bone. The enzymes were modified with a short targeting moiety that mediated accumulation of the therapeutic in osteoblasts and additionally enables targeting of intracellularly surviving bacteria