Tratamiento quirúrgico de enucleación completa y análisis histológico de un mucocele en el labio inferior en un niño: Reporte de Caso.

Objective: The aim of this case report is to describe the surgical removal of a mucocele and its histological analysis, in a child. Case Report: An 11-year-old female patient attended the Pediatric Dentistry clinic complaining of a lower lip lesion. During the anamnesis, the mother reported that the child had a habit of biting and sucking the spot frequently. Clinical examination showed the lesion was compatible with a mucocele. The proposed treatment was a complete enucleation of the lesion under local anesthesia. The incision and tissue divulsion were performed for maximum preservation of the mucosa, avoiding a possible recurrence. Total adjacent glands removal was also performed. The lesion was placed in 10% formaldehyde for histopathological analysis (H&E Staining), which showed dense connective tissue presenting chronic inflammatory infiltrate and extravasated mucin, presence of granulation tissue delimiting the area of extravasated mucin and presence of minor salivary glands. The patient was advised to quit the habit, and after seven days the sutures were removed. At the one-year follow-up there was no recurrence of the lesion. Conclusion: The proposed treatment proved to be effective without recurrence of the lesion.Objetivo: El objetivo de este reporte de caso es describir la extirpación quirúrgica de un mucocele y su análisis histológico en un niño. Informe del caso: una paciente de 11 años de edad asistió a la clínica de Odontopediatria quejándose de una lesión en el labio inferior. Durante la anamnesis, la madre informó que el niño tenía la costumbre de morder y chupar el lugar con frecuencia. En el examen clínico, la lesión fue compatible con un mucocele. El tratamiento propuesto fue una enucleación completa de la lesión bajo anestesia local. La incisión y la divulgación del tejido se realizaron para la máxima preservación de la mucosa, evitando una posible recurrencia. También se realizó la extracción total de las glándulas adyacentes. La lesión se colocó en formaldehído al 10% para el análisis histopatológico (tinción H&E), que mostró tejido conectivo denso que presenta infiltrado inflamatorio crónico y mucina extravasada, presencia de tejido de granulación que delimita el área de mucina extravasada y presencia de glándulas salivales menores. Se aconsejó al paciente que abandonara el hábito, y después de siete días se retiraron las suturas. En el seguimiento de un año no hubo recurrencia de la lesión. Conclusión: El tratamiento propuesto demostró ser efectivo sin recurrencia de la lesión

Risk Factors for Different Types of Traumatic Injuries in Primary Teeth

Objective: To evaluate traumatic dental injuries (TDI) in primary teeth and the association of gender and age with different injuries. Material and Methods: Records of patients with TDI in primary teeth were included. The following parameters were registered: gender and age, place of trauma, cause of trauma, affected tissue and tooth, number of injured teeth, type of injury, and gingival and bone damage. A logistic regression analysis was performed to explore the interaction between gender and age on the occurrence of types of injuries (p≤0.05). Results: The total of 721 records were evaluated and 370 records were included, being 61.6% boys and 60.5% children aged 0–3 years old, with 658 primary teeth affected. The support tissue was most affected (496/658), followed by dental tissue (139/658). Enamel/dentine fracture with pulp exposure (n=51) and intrusion (n=131) were the most common injuries of dental and support tissues, respectively. In general, boys suffered more traumas than girls, regardless of the age range. As for concussion, logistic regression confirms that gender and age are also influencers. Girls (OR=1.822, CI = 1.050-3.164, p=0.033) in the 4–6 year age group (OR=2.15, CI = 1.239–3.747, p=0.007) are more likely to have concussions. Children age 4–6 years were less likely to suffer an intrusion (OR=0.496; CI = 0.278– 0.886; p=0.018). Conclusion: Gender and age influence concussion and intrusion in the primary teeth

Influence of Environmental Factors on the Presence and Severity of Molar Incisor Hypomineralization

Objective: To assess the association between environmental factors during pregnancy and early childhood with the presence and severity of Molar Incisor Hipomineralization (MIH). Material and Methods: This cross-sectional study was conducted with 120 patients between 7 and 14 years of age. MIH was evaluated according to EAPD criteria. Data collected included the child’s medical history and the mother’s health. Chi-square and logistic regression were performed to determine any statistical evidence of the environmental factors, with the significance level set at 5%. Results: The participants were divided into groups with MIH (n=60) and without MIH (n=60), with average ages of 9.9 (±1.9) and 9.7 (±1.7) years, respectively. There was a statistically significant difference between intercurrences during pregnancy (OR=3.55; IC95%=1.35-10.57) and medication taken by the child (OR=3.01; IC95%=1.74-8.42) and the presence of MIH. In addition, other variables were also associated with the MIH (p≤0.05). However, there was no association with variables and degree of MIH severity (p>0.05). Conclusion: The use of medications in childhood and complications during pregnancy can be association to the presence of MIH. However, these factors do not interaction to MIH severity

A 14-Year Follow-Up Study of Sequelae in Primary Teeth and Permanent Successors After Dental Trauma

Objective: To evaluate the presence of sequelae in primary teeth and their permanent successors, as well as associations between TDI and the presence of sequelae in both teeth. Material and Methods: In this 14-year retrospective study, 2.290 records were reviewed, 192 patients who suffered dental trauma in primary teeth were followed until the eruption of successor teeth were included. Descriptive, chi-square, and regression logistic with generalized estimating equations tests were performed (p<0.05). Results: 362 primary and successor teeth were followed. Sequelae were present in 71.8% of primary teeth and 25.7% of their successors. Teeth with complicated fracture (100%), extrusion (100%) and avulsion (100%) resulted in the largest amounts of sequelae in primary teeth and intrusion (61%) on their successors. Age was associated with sequelae in permanent teeth (p<0.01). Extrusion (OR 10.06; CI 2.12-47.63) and intrusion (OR 7.51; CI 2.73-20.70) had a higher risk to cause sequelae in primary and permanent teeth, respectively. Conclusion: The type of injury involved influenced the sequelae in traumatized teeth and their successors, and the age of the child influenced the presence of sequelae in permanent teeth.&nbsp

Hiperpigmentação Mucocutânea Associada à Terapia de Hidroxiureia em Paciente com Trombocitemia Essencial: Relato de Caso

Introdução: A hiperpigmentação mucocutânea é uma condição dermatológica que pode estar relacionada a tratamentos quimioterápicos, a exemplo das terapias com uso de hidroxiureia (HU). A HU é um fármaco citostático de amplo uso nas doenças mieloproliferativas e compõe a principal linha de tratamento da trombocitemia essencial (TE). O presente estudo tem por objetivo relatar um caso raro de hiperpigmentação mucocutânea em um paciente com TE. Relato do caso: Paciente do sexo masculino, 68 anos de idade, 89 kg, com diagnóstico de TE, em uso de HU 2 g/dia. Com três meses de terapia, apresentou lesões hiperpigmentadas de coloração acastanhadas em pele das mãos e mucosa oral (língua). Em decisão partilhada com o médico-assistente, o paciente optou pela continuação do uso do medicamento. Após seis anos de acompanhamento, as lesões mantêm-se estáveis. Conclusão: A hiperpigmentação mucocutânea associada à terapia com HU é um evento benigno secundário ao uso do fármaco e não exige a interrupção de uso, porém, sua retirada, ou redução das doses, geralmente leva à diminuição ou ao desaparecimento das lesões

Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others

Revista de Ciências Médicas e Biológicas

Abstract Objective: The purpose of this case report was to describe the successful management of unerupted incisors due to an odontoma in two young girls with history of dental trauma in primary teeth. Case report: The radiographic examinations revealed odontoma-like malformations, which were surgically removed in both cases. In case 1 the crown of the permanent tooth was exposed and orthodontic traction performed and in case 2, a waiting period of at least 6 months for spontaneous eruption of permanent tooth was expected. After 8 months it was necessary the orthodontic traction because the tooth had not erupted. In both cases the correct alignment of the upper incisors was achieved, the final occlusion was satisfactory and periapical radiographs revealed no pathological signs. Conclusion: The satisfactory results confirmed the advantages of these approaches, which restored the esthetics and oral function of these two young patients. Keywords: Tooth. Unerupted. Orthodontic Appliances.Objetivo: O objetivo deste relato de caso foi descrever a gestão bem sucedida de incisivos inclusos devido a um odontoma em duas jovens com história de trauma dental em dentes decíduos. Relato do caso: Os exames radiográficos revelaram malformações odontoma-like, os quais foram removidos cirurgicamente em ambos os casos. No caso 1, a coroa do dente permanente foi exposta e tracção ortodôntico realizada e, no caso 2, era esperado um período de espera de pelo menos 6 meses para a erupção espontânea de dentes permanentes. Após 8 meses, foi necessário o tracionamento ortodôntico, pois o dente não tinha entrado em erupção. Em ambos os casos foi obtido o correto alinhamento dos incisivos superiores, a oclusão final foi satisfatório e radiografias periapicais não revelou sinais patológicos. Conclusão: Os resultados satisfatórios confirmaram as vantagens dessas abordagens, que restaurou a estética e a função oral desses dois pacientes jovens.Salvado

Bloqueio do receptor AT1 da angiotensina: um dos alvos terapêuticos da doença hepática gordurosa não alcoólica?

A doença hepática gordurosa não alcoólica (DHGNA) é altamente prevalente e seus portadores possuem risco aumentado de desenvolver doenças cardiovasculares, inclusive a hipertensão arterial sistêmica (HAS). A prevalência de HAS nesses pacientes é estimada em 39,34%, entretanto, não há critérios de escolha de anti-hipertensivos nesse contexto. 34 coelhos foram divididos em grupo olmesartana (GO) n=12, grupo controle (GC) n=13, e grupo controle normal (GCN) n=9. O GCN recebeu ração padrão e os GC e GO ração padrão acrescida de colesterol a 1%. O GO recebeu a olmesartana via oral, 1mg/kg/dia em todo o período do estudo. Amostras de sangue e de tecido hepático foram coletadas na eutanásia (8ª semana). Houve atenuação significativa da esteatose, balonização e do estresse oxidativo, e prevenção da inflamação e fibrose hepática no GO. O escore de atividade foi significativamente menor no GO, podendo-se concluir que, nesse modelo, a olmesartana atenuou significativamente o desenvolvimento de DHGNA. &nbsp