Topics in Delayed Renewal Risk Models

Main focus is to extend the analysis of the ruin related quantities, such as the surplus immediately prior to ruin, the deficit at ruin or the ruin probability, to the delayed renewal risk models. First, the background for the delayed renewal risk model is introduced and two important equations that are used as frameworks are derived. These equations are extended from the ordinary renewal risk model to the delayed renewal risk model. The first equation is obtained by conditioning on the first drop below the initial surplus level, and the second equation by conditioning on the amount and the time of the first claim. Then, we consider the deficit at ruin in particular among many random variables associated with ruin and six main results are derived. We also explore how the Gerber-Shiu expected discounted penalty function can be expressed in closed form when distributional assumptions are given for claim sizes or the time until the first claim. Lastly, we consider a model that has premium rate reduced when the surplus level is above a certain threshold value until it falls below the threshold value. The amount of the reduction in the premium rate can also be viewed as a dividend rate paid out from the original premium rate when the surplus level is above some threshold value. The constant barrier model is considered as a special case where the premium rate is reduced to $0$ when the surplus level reaches a certain threshold value. The dividend amount paid out during the life of the surplus process until ruin, discounted to the beginning of the process, is also considered

Sources of variability in daily physical activity for secondary students with and without developmental disabilities

Generalizability theory was used to examine sources of variability in daily physical activity levels of secondary students with and without developmental disabilities (DD), and to determine minimum number of days required for monitoring their typical physical activity levels. Sixteen participants with DD (M = 16.7 years, SD = 2.7 years), and thirty-one (M = 12.3 years, SD = 0.5 years) children without DD participated in the study. They wore two pedometers and two accelerometers during 5 weekdays and 4 weekend days. Sources of variability were examined using a two-facet fully crossed design. Twelve separate two-way ANOVAs were employed for each population, physical activity device, and measurement periods (weekday, weekends, and weekdays and weekends combined). For participants with DD, variance components of the person, and the person by day interaction were the primary sources of variability in daily physical activity for pedometers and accelerometers across weekdays, weekend days, and weekdays and weekends combined. To determine the typical physical activity level with generalizability coefficients of .80, at least 4, 6, and 8 days of measurement using a pedometer were required during weekdays, weekend days, and weekdays and weekends combined, respectively. Using an accelerometer, at least 4 days of measurements were needed across weekdays, weekends, and weekdays and weekends combined. For participants without DD, the primary sources of variability during weekdays and weekends were related to variance components of the persons and the person by day interaction for both pedometers and accelerometers. When weekdays and weekends were combined, relatively large percentages of variability were associated with the residual, indicating three way interaction, plus unexplained error. Using one pedometer, to achieve generalizability coefficients of .80 in the measurement of daily physical activity, a minimum number of 5 and 9 days of measurements during weekday and weekends were estimated, respectively. Using one accelerometer, at least 4 days and 14 days of monitoring physical activity were required during weekdays, and weekdays and weekends combined, respectively. However, an estimation of typical physical activity levels during weekdays and weekends combined, using one pedometer as well as during weekends using one accelerometer was unfeasible due to the number of days required for measurement

Immune-enhancing screening of fourteen plants on murine macrophage RAW 264.7 cells

Purpose: To investigate the potential immune-enhancing effects of fourteen natural plant extracts on mouse macrophage RAW 264.7 cells.Methods: Fourteen plant extracts from 7 different plants were tested on RAW 264.7 cells to determine their immunostimulant activities. Methylthiazolydiphenyltetrazolium bromide (MTT) and Griess assays were performed to evaluate cell viability and nitric oxide (NO) production, respectively. Then, immune related proteins were measured by western blot analysis, while cytokines and phagocytic activity were determined by enzyme-linked immunosorbent assay (ELISA) method.Results: Among the 14 plant extracts, the hot water extract of Agastache rugose was selected based on the screening results on NO production. The hot water extract of A. rugose significantly increased NO production in a concentration-dependent manner without any cytotoxicity. In addition, the expression levels of proteins (iNOS and COX-2) and cytokines (TNF-α, IL-1β, IL-6 and IL-12) closely related to immune reaction were also significantly upregulated. Furthermore, phagocytic activity of RAW 264.7 cells significantly increased following treatment with A. rugosa.Conclusion: The hot water extract of A. rugosa exhibits significant immune-stimulant activity. Therefore, A. rugosa can be used as a natural resource for immune enhancement or dietary supplement.Keywords: Immune enhancing activity, Macrophage polarization, Natural plant extracts, Agastache rugosa, RAW 264.

Influence of Heterointerfaces on the Kinetics of Oxygen Surface Exchange on Epitaxial La1.85Sr0.15CuO4 Thin Films

Considerable attention has been directed to understanding the influence of heterointerfaces between Ruddlesden-Popper (RP) phases and ABO(3) perovskites on the kinetics of oxygen electrocatalysis at elevated temperatures. Here, we report the effect of heterointerfaces on the oxygen surface exchange kinetics by employing heteroepitaxial oxide thin films formed by decorating LaNiO3 (LNO) on La1.85Sr0.15CuO4 (LSCO) thin films. Regardless of LNO decoration, tensile in-plane strain on LSCO films does not change. The oxygen surface exchange coefficients (k(chem)) of LSCO films extracted from electrical conductivity relaxation curves significantly increase with partial decorations of LNO, whereas full LNO coverage leads to the reduction in the k(chem) of LSCO films. The activation energy for oxygen exchange in LSCO films significantly decreases with partial LNO decorations in contrast with the full coverage of LNO. Optical spectroscopy reveals the increased oxygen vacancies in the partially covered LSCO films relative to the undecorated LSCO film. We attribute the enhanced oxygen surface exchange kinetics of LSCO to the increased oxygen vacancies by creating the heterointerface between LSCO and LNO

Charge-spin correlation in van der Waals antiferromagenet NiPS3

Strong charge-spin coupling is found in a layered transition-metal trichalcogenide NiPS3, a van derWaals antiferromagnet, from our study of the electronic structure using several experimental and theoretical tools: spectroscopic ellipsometry, x-ray absorption and photoemission spectroscopy, and density-functional calculations. NiPS3 displays an anomalous shift in the optical spectral weight at the magnetic ordering temperature, reflecting a strong coupling between the electronic and magnetic structures. X-ray absorption, photoemission and optical spectra support a self-doped ground state in NiPS3. Our work demonstrates that layered transition-metal trichalcogenide magnets are a useful candidate for the study of correlated-electron physics in two-dimensional magnetic material.Comment: 6 pages, 3 figur

Unconventional spin-phonon coupling via the Dzyaloshinskii???Moriya interaction

Spin-phonon coupling (SPC) plays a critical role in numerous intriguing phenomena of transition metal oxides (TMOs). In 3d and 4d TMOs, the coupling between spin and lattice degrees of freedom is known to originate from the exchange interaction. On the other hand, the origin of SPC in 5d TMOs remains to be elucidated. To address this issue, we measured the phonon spectra of the 5d pyrochlore iridate Y 2 Ir 2 O 7 using optical spectroscopy. Three infrared-active phonons soften below the N??el temperature of T N ??? 170 K, indicating the existence of strong SPC. Simulations using density functional theory showed that the coupling is closely related to the Ir???O???Ir bond angle. A tight-binding model analysis reveals that this SPC is mainly mediated by the Dzyaloshinskii???Moriya interaction rather than the usual exchange interaction. We suggest that such unconventional SPC may be realized in other 5d TMOs with non-collinear magnetic order

Purification and characterization of angiotensin-1 converting enzyme (ACE)-inhibitory peptide from the jellyfish, Nemopilema nomurai

The Nemopilema nomurai hydrolysate was produced by the reaction of papain, and an angiotensin-Ι converting enzyme (ACE)-inhibitory peptide was purified by using the molecular cut-offs membrane filter, the gel filtration chromatography with Sephadex LH-20 and the reverse phase chromatographic method using C18 and C12 columns. Purification yield of the active peptide was estimated to be 0.2 ± 0.1%, starting from the lyophilized jellyfish. The infrared (IR), proton nuclear magnetic resonance spectroscopy (1H NMR), carbon nuclear magnetic resonance (13C NMR) and mass spectrometry (MS) spectrometer analyses elucidated that the structure of the purified peptide is tyrosine-isoleucine (Tyr-Ile). The inhibitory concentration at 50% (IC50) and Ki values were calculated to be 2.0 ± 0.3 μg/ml and 3.3 ± 0.3 μM, respectively, which acts as a competitive inhibitor to ACE.Keywords: Angiotensin-Ι converting enzyme, Jellyfish, Nemopilema nomurai, Papain hydrolysate, Tyrosine-IsoleucineAfrican Journal of Biotechnology Vol. 12(15), pp. 1888-189

Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation

As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery for stroke rehabilitation. In this study, we propose an engineering approach with subthreshold electrical stimulation (STES) to bring functional recovery. Here, we show a low level of electrical stimulation boosted causal excitation in connected neurons and strengthened the synaptic weight in a simulation study. We found that STES with motor training enhanced functional recovery after stroke in vivo. STES was shown to induce neural reconstruction, indicated by higher neurite expression in the stimulated regions and correlated changes in behavioral performance and neural spike firing pattern during the rehabilitation process. This will reduce the energy consumption of implantable devices and the side effects caused by stimulating unwanted brain regions. © 2021, The Author(s).1