15 research outputs found
Effects of three-day bed rest on metabolic, hormonal and circulatory responses to an oral glucose load in endurance or strength trained athletes and untrained subjects
Effects of 3 day bed rest on physiological responses to graded exercise in athletes and sedentary men
32 sujets répartis en trois groupes (12 sujets sédentaires, 10 athlètes entrainés en endurance et 10 autres entrainés à la force) sont restés couchés durant trois jours et ont réalisé progressivement un exercice-test jusqu'à l'épuisement volontaire. Mesure des réponses métaboliques, cardiorespiratoires et neurohormonales. Analyse des résultats et comparison entre les groupe
Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies
Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence
Effect of alterations in blood volume with bed rest on glucose tolerance
Bed rest leads to rapid impairments in glucose tolerance. Plasma volume and thus dilution space for glucose are also reduced with bed rest, but the potential influence on glucose tolerance has not been investigated. Accordingly, the aim was to investigate whether bed rest-induced impairments in glucose tolerance are related to a concomitant reduction in plasma volume. This hypothesis was tested mechanistically by restoring plasma volume with albumin infusion after bed rest and parallel determination of glucose tolerance. Fifteen healthy volunteers (age 24 ± 3 yr, body mass index 23 ± 2 kg/m(2), maximal oxygen uptake 44 ± 8 ml·min(-1)·kg(-1); means ± SD) completed 4 days of strict bed rest. Glucose tolerance [oral glucose tolerance test (OGTT)] and plasma and blood volumes (carbon monoxide rebreathing) were assessed before and after 3 days of bed rest. On the fourth day of bed rest, plasma volume was restored by means of an albumin infusion prior to an OGTT. Plasma volume was reduced by 9.9 ± 3.0% on bed rest day 3 and area under the curve for OGTT was augmented by 55 ± 67%. However, no association (R(2) = 0.09, P = 0.33) between these simultaneously occurring responses was found. While normalization of plasma volume by matched albumin administration (408 ± 104 ml) transiently decreased (P < 0.05) resting plasma glucose concentration (5.0 ± 0.4 to 4.8 ± 0.3 mmol/l), this did not restore glucose tolerance. Bed rest-induced alterations in dilution space may influence resting glucose values but do not affect area under the curve for OGTT