The effect of offset cues on saccade programming and covert attention

Salient peripheral events trigger fast, “exogenous” covert orienting. The influential premotor theory of attention argues that covert orienting of attention depends upon planned but unexecuted eye-movements. One problem with this theory is that salient peripheral events, such as offsets, appear to summon attention when used to measure covert attention (e.g., the Posner cueing task) but appear not to elicit oculomotor preparation in tasks that require overt orienting (e.g., the remote distractor paradigm). Here, we examined the effects of peripheral offsets on covert attention and saccade preparation. Experiment 1 suggested that transient offsets summoned attention in a manual detection task without triggering motor preparation planning in a saccadic localisation task, although there were a high proportion of saccadic capture errors on “no-target” trials, where a cue was presented but no target appeared. In Experiment 2, “no-target” trials were removed. Here, transient offsets produced both attentional facilitation and faster saccadic responses on valid cue trials. A third experiment showed that the permanent disappearance of an object also elicited attentional facilitation and faster saccadic reaction times. These experiments demonstrate that offsets trigger both saccade programming and covert attentional orienting, consistent with the idea that exogenous, covert orienting is tightly coupled with oculomotor activation. The finding that no-go trials attenuates oculomotor priming effects offers a way to reconcile the current findings with previous claims of a dissociation between covert attention and oculomotor control in paradigms that utilise a high proportion of catch trials

Experimental analysis of dynamic charge acceptance test conditions for lead-acid cells

© 2016 IEEE.This paper presents the results of a series of tests to determine the Dynamic Charge Acceptance (DCA) performance of small form-factor 2 V, 6 Ah, carbon-enhanced VRLA cells designed for Hybrid Electric Vehicle (HEV) applications. A test procedure has been written for a battery test system, based on a modified DCA Short Test profile. Results have been obtained for a batch of cells, tested at various temperatures, rest periods and states of charge. These conditions have been chosen to mimic a range of real-life scenarios which could potentially be encountered during HEV operation. The resulting analysis demonstrates clear variations and trends in DCA performance which may be used to inform conditions for future testing regimes. The same test procedure is then applied to standard lead-acid cells and the results compared

Spatial Attention and Spatial Short Term Memory in PSP and Parkinson’s Disease

Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorder characterised by deterioration in motor, oculomotor and cognitive function. A key clinical feature of PSP is the progressive paralysis of eye movements, most notably for vertical saccades. These oculomotor signs can be subtle, however, and PSP is often misdiagnosed as Parkinson’s disease (PD), in its early stages. Although some of the clinical features of PD and PSP overlap, they are distinct disorders with differing underlying pathological processes, responses to treatment and prognoses. One key difference lies in the effects the diseases have on cognition. The oculomotor system is tightly linked to cognitive processes such as spatial attention and spatial short-term memory (sSTM), and previous studies have suggested that PSP and PD experience different deficits in these domains. We therefore hypothesised that people with PSP (N = 15) would experience problems with attention (assessed with feature and conjunction visual search tasks) and sSTM (assessed with the Corsi blocks task) compared to people with PD (N = 16) and Age Matched Controls (N = 15). As predicted, feature and conjunction search were sgnificantly slower in the PSP group compared to the other groups, and this deficit was significantly worse for feature compared to conjunction search. The PD group did not differ from AMC on feature search but were significantly impaired on the conjunction search. The PSP group also had a pronounced vertical sSTM impairment that was not present in PD or AMC groups. It is argued that PSP is associated with specific impairment of visuospatial cognition which is caused by degeneration of the oculomotor structures that support exogenous spatial attention, consistent with oculomotor theories of spatial attention and memory

Idiopathic chondrolysis, of the hip - A case report

A report of a case of idiopathic chondrolysis of the right hip in a 13-year-old Black girl is presented. Radiographs and microbiological and biochemical investigations excluded all other diseases. Cartilage and synovium were removed at biopsy of the right hip. Macroscopic and histopathological studies showed the typical features of idiopathic chondrolysis. Transmission electron microscopy confirmed the histological findings. Scanning electron microscopy highlighted the irregular pitted and fibrillated surface of the cartilage. Immunofluorescent studies. on cartilage and synovium were negative. The possible pathogenesis of the disease is discussed, but the cause still remains unknown

Investigation of in vivo measurement of cerebral cytochrome-c-oxidase redox changes using near-infrared spectroscopy in patients with orthostatic hypotension

We have previously used a continuous four wavelength near infrared spectrometer to measure changes in the cerebral concentrations of oxy- (Δ[HbO2] and deoxy- haemoglobin (Δ[HHb]) during head-up tilt in patients with primary autonomic failure. The measured changes in light attenuation also allow calculation of changes in the concentration of oxidised cytochrome c oxidase (Δ[oxCCO]), and this paper analyses the Δ[oxCCO] during the severe episodes of orthostatic hypotension produced by this experimental protocol. We studied 12 patients during a passive change in position from supine to a 60º head-up tilt. The challenge caused a reduction in mean blood pressure of 59.93 (±26.12) mmHg (Mean (±SD), p<0.0001), which was associated with a reduction in the total concentration of haemoglobin (Δ[HbT]= Δ[HbO2]+Δ[HHb]) of 5.02 (±3.81) μM (p<0.0001) and a reduction in the haemoglobin difference concentration (Δ[Hbdiff]= Δ[HbO2]-Δ[HHb]) of 14.4 (±6.73) μM (p<0.0001). We observed a wide range of responses in Δ[oxCCO]. 6 patients demonstrated a drop in Δ[oxCCO] (0.17 ±0.15μM ); 4 patients demonstrated no change (0.01 ±0.12 μM ) and 2 patients showed an increase in Δ[oxCCO] (0.21 ±0.01 μM ). Investigation of the association between the changes in concentrations of haemoglobin species and the Δ[oxCCO] for each patient show a range of relationships. This suggests that a simple mechanism for crosstalk, which might produce artefactual changes in [oxCCO], is not present between the haemoglobin and the oxCCO NIRS signals. Further investigation is required to determine the clinical significance of the changes in [oxCCO]

An analysis of the influence of high-frequency ripple currents on dynamic charge acceptance in lead-acid batteries

This paper presents the results of an experimental analysis of the influence of high-frequency injected ripple currents on the Dynamic Charge Acceptance (DCA) performance of lead-acid batteries. A wide-bandwidth battery model, derived from real-world data is described, this being a hybrid of the standard Randles model and a high-frequency model previously presented in literature. A bespoke test procedure is introduced, based on the existing DCA Short Test profile (EN50342-6). The results demonstrate that the injection of ripple currents can significantly improve charge acceptance, whilst having no appreciable effect on the State of Charge (SoC) of the battery. This study further demonstrates the importance of knowledge of the impedance spectrum of the battery if the improvements in DCA performance are to be achieved with maximum efficiency and effectiveness

Covert visual search within and beyond the effective oculomotor range

Covert spatial attention is tightly coupled to the eye-movement system, but the precise nature of this coupling remains contentious. Recent research has argued that covert attention and overt eye-movements many share a common biological limit, such that covert exogenous orienting of attention is limited to stimuli that fall within the range of possible eye movements (the effective oculomotor range: EOMR). However, this conclusion is based on a single experimental paradigm: The Posner cueing task. Here, we examine the extent to which covert spatial attention is limited to the EOMR in visual search. Exogenous attention was assessed using a feature search task and endogenous attention assessed using a conjunction search task. The tasks were performed monocularly with the dominant eye in the frontal position or abducted by 40°. In the abducted position stimuli in the temporal hemispace could be seen, but could not become the goal of a saccadic eye-movement (i.e. they were beyond the EOMR). In contrast, stimuli in the nasal hemifield remained within the EOMR. We observed a significant effect of eye-abduction on feature search, such that search was slower when targets appeared beyond the EOMR. In contrast, eye-abduction had no effect on search times during conjunction search. Set size did not interact with target location or eye-position. It is concluded that optimal covert orienting of exogenous attention in visual search is restricted to locations within the effective oculomotor range

Rewards modulate saccade latency but not exogenous spatial attention

The eye movement system is sensitive to reward. However, whilst the eye movement system is extremely flexible, the extent to which changes to oculomotor behavior induced by reward paradigms persist beyond the training period or transfer to other oculomotor tasks is unclear. To address these issues we examined the effects of presenting feedback that represented small monetary rewards to spatial locations on the latency of saccadic eye movements, the time-course of learning and extinction of the effects of rewarding saccades on exogenous spatial attention and oculomotor inhibition of return. Reward feedback produced a relative facilitation of saccadic latency in a stimulus driven saccade task which persisted for three blocks of extinction trials. However, this hemifield-specific effect failed to transfer to peripheral cueing tasks. We conclude that rewarding specific spatial locations is unlikely to induce long-term, systemic changes to the human oculomotor or attention systems