Donn L. Smith oral history interview by Nancy Hewitt, July 24, 1985

Dr. Donn Smith, professor of Medicine at USF, recalls his time at the University

Effect of 1α,25-Dihydroxyvitamin D3 on the Morphologic and Biochemical Differentiation of Cultured Human Epidermal Keratinocytes Grown in Serum-Free Conditions

The effect of 1α,25-dihydroxyvitamin D3 [1α,25-(OH)2- D3] on the proliferation and morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown under defined, serum-free conditions was studied. 1α,25-(OH)2-D3 caused a dose-dependent decrease in proliferation and an increase in the morphologic differentiation of human cultured keratinocytes. The number of attached basal cells decreased when exposed to 1α,25-(OH)2-D3, whereas the number of attached squamous cells, terminally differentiated desquamated cells, and cornified cells increased concurrently. In addition, alter incubation with 1α,25-(OH)2-D3, there was a shift to cells of lighter density. In conjunction with its effect on the basal cells, 1α,25-(OH)2-D3 resulted in an inhibition of DNA synthesis. The activity of transglutaminase, the enzyme responsible for cross-linking the proteins of the cornified envelope, was stimulated by 156% with 1α,25-(OH)2-D3, but not with 1β,25-(OH)2-D3 is a biologically inert isomer. Therefore it appears that 1α,25-(OH)2-D3 is a potent inhibitor of keratinocyte proliferation as well as a stimulator of epidermal terminal differentiation

Prostate Cancer Survivorship: Prevention and Treatment of the Adverse Effects of Androgen Deprivation Therapy

BACKGROUND: More than one-third of the estimated 2 million prostate cancer survivors in the United States receive androgen deprivation therapy (ADT). This population of mostly older men is medically vulnerable to a variety of treatment-associated adverse effects. MEASUREMENTS AND RESULTS: Androgen-deprivation therapy (ADT) causes loss of libido, vasomotor flushing, anemia, and fatigue. More recently, ADT has been shown to accelerate bone loss, increase fat mass, increase cholesterol and triglycerides, and decrease insulin sensitivity. Consistent with these adverse metabolic effects, ADT has also recently been associated with greater risks for fractures, diabetes and cardiovascular disease. CONCLUSION: Primary care clinicians and patients should be aware of the potential benefits and harms of ADT. Screening and intervention to prevent treatment-related morbidity should be incorporated into the routine care of prostate cancer survivors. Evidence-based guidelines to prevent fractures, diabetes, and cardiovascular disease in prostate cancer survivors represent an important unmet need. We recommend the adapted use of established practice guidelines designed for the general population

Statoconia Formation in Molluscan Statocysts

The gravity sensors of all molluscs phylogenetically below the cephalopods are spherical organs called statocysts. The wall of the sphere contains mechanosensory cells whose sensory cilia project into the lumen of the cyst. The lumen is filled with fluid and dense stones , the statoconia or statoliths, which sink under the influence of gravity to load, and stimulate, those receptor cells which are at the bottom. The statuconia of Aplysia californica are shown to be calcified about a lamellar arrangement of membranes. Similar lamellar membrane arrangements are seen within the receptor cells, and their possible role in the formation of the statoconia is discussed. SEM of unfixed statoconia reveals plate-like crystallization on their surface. Elemental analysis shows a relatively high Sr content, which is of interest, since others have recently reported that Sr is required in the culture medium of several laboratory-reared molluscs in order for the statoconia to develop

Teachers Learn About ADHD on the Web: An Online Graduate Special Education Course

This is the publisher's version, also found here: www.sped.orgDescribes several possibilities for using Internet-based applications to enhance teacher preparation to better serve students with attention-deficit/hyperactivity disorder (ADHD). Features of the Web-enhanced course, The Learner with ADHD which offers a general introduction to characteristics, treatment and education of students with ADHD. INSETS: Perspectives on distance learning; WebCT-an online course tool

Building a politics of connectivity: intercultural in-commonness in Fairtrade

Fairtrade operates its global system through a homogenising but marketable set of standards. Combined with issues around how to include producers in governance, this has led to feelings of disconnection and disenfranchisement for the latter, which are impacting on Fairtrade’s effectiveness and legitimacy. Through a focus on the South African wine industry, this paper argues that the Fairtrade community needs to be reinvigorated through dialogical communication, impactful participation and cultural synthesis to better enact responsibility across its systemic geographical and cultural distances. “Being‐with” its multiple stakeholders makes space for a more responsive, contextual and connected system. Drawing on the ideas of Paulo Freire, the paper concludes that a Fairtrade built on solidarity through a participatory and decentralised system would allow for discussions of the ideals and practices that are essential to negotiating, and not swallowing up, the shifting “we” of Fairtrade and more effectively balancing its local and global responsibilities

Word service for grades one through six

Thesis (Ed.M.)--Boston Universit

Observation operators for assimilation of satellite observations in fluvial inundation forecasting

Images from satellite-based synthetic aperture radar (SAR) instruments contain large amounts of information about the position of flood water during a river flood event. This observational information typically covers a large spatial area, but is only relevant for a short time if water levels are changing rapidly. Data assimilation allows us to combine valuable SAR derived observed information with continuous predictions from a computational hydrodynamic model and thus to produce a better forecast than using the model alone. In order to use observations in this way a suitable observation operator is required. In this paper we show that different types of observation operator can produce very different corrections to predicted water levels; this impacts on the quality of the forecast produced.We discuss the physical mechanisms by which different observation operators update modelled water levels and introduce a novel observation operator for inundation forecasting. The performance of the new operator is compared in synthetic experiments with that of two more conventional approaches. The conventional approaches both use observations of water levels derived from SAR to correct model predictions. Our new operator is instead 10 designed to use backscatter values from SAR instruments as observations; such an approach has not been used before in an ensemble Kalman filtering framework. Direct use of backscatter observations opens up the possibility of using more information from each SAR image and could potentially speed up the time taken to produce observations needed to update model predictions. We compare the strengths and weaknesses of the three different approaches with reference to the physical mechanisms by which each of the observation operators allow data assimilation to update water levels in synthetic twin experiments in an idealised domain

Managing Opportunities and Challenges of Co-Authorship

Research with the largest impact on practice and science is often conducted by teams with diverse substantive, clinical, and methodological expertise. Team and interdisciplinary research has created authorship groups with varied expertise and expectations. Co-authorship among team members presents many opportunities and challenges. Intentional planning, clear expectations, sensitivity to differing disciplinary perspectives, attention to power differentials, effective communication, timelines, attention to published guidelines, and documentation of progress will contribute to successful co-authorship. Both novice and seasoned authors will find the strategies identified by the Western Journal of Nursing Research Editorial Board useful for building positive co-authorship experiences