Wage and Occupational Differences Between Black and White Men: Labor Market Discrimination in the Rural South

The existence of labor market discrimination based on race is well established.However, study continues into a variety of aspects of discrimination-among them the extent to which it exists in different regions. Gwartney has estimated the ratio of black to white earnings to be between .83 and .88 for the North and between .68 and .74 for the South. Masters, in a study of earnings differentials between black and white men, found a ratio of .79 for the non-South and .69 for the South. Although considerable literature has developed concerning earnings differentials, wage discrimination in rural areas is one topic which has received relatively little attention. In an attempt to eliminate this oversight this paper concentrates on the extent of wage differences between black and white men in the rural South attributable to labor market discrimination

Evolution of mammalian social structure

Social groups may be viewed as collections of individuals exhibiting nonindependent behavior and organized in a cooperative manner. The evolutionary advantage of social behavior to individuals must be measured in its relativity to other potential behaviors, the scale of competitive interactions, and under a variety of environmental and genetic constraints. A primary tenet of social evolution is that coancestry will promote the genes of related individuals. High values of coancestry, however, do not necessarily translate into evolutionary advantage unless the primary competitive interactions occur among the groups. Coancestry is affected by the breeding tactics within and rates of genetic exchange among social groups. Low rates of exchange among groups, regardless of breeding tactics, may result in high values for intragroup coancestry but may lead to inbreeding depression in progeny. Likewise, breeding tactics such as polygyny, may not impart any long-lasting evolutionary advantage if genetic exchange rates are high. The evolution of social organizations typified by different breeding and migration strategies is evaluated to determine the conditions necessary for various tactics to result in genetic contributions by individuals equal to those of monogamous mating systems. The models show that breeding and dispersal tactics have probably evolved in concert and predict that social groups which are characterized by strong gene correlations are likely to exhibit relatively low group advantage for progeny survival and breeding. There is little impetus for high gene correlations to accrue in situations where group advantage is very high relative to monogamous systems

Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells.

LCK is a tyrosine kinase that is essential for initiating T-cell antigen receptor (TCR) signaling. A complete understanding of LCK function is constrained by a paucity of methods to quantitatively study its function within live cells. To address this limitation, we generated LCK*, in which a key active-site lysine is replaced by a photocaged equivalent, using genetic code expansion. This strategy enabled fine temporal and spatial control over kinase activity, thus allowing us to quantify phosphorylation kinetics in situ using biochemical and imaging approaches. We find that autophosphorylation of the LCK active-site loop is indispensable for its catalytic activity and that LCK can stimulate its own activation by adopting a more open conformation, which can be modulated by point mutations. We then show that CD4 and CD8, T-cell coreceptors, can enhance LCK activity, thereby helping to explain their effect in physiological TCR signaling. Our approach also provides general insights into SRC-family kinase dynamics