Demonstrating the effect of live weight on heifer pregnancy rates in northern Queensland

A group of beef producers north of Charters Towers identified low heifer pregnancy rates as a consistent and significant problem, aligning with the regional median from the Cash Cow project of 67%. Results from their Producer Demonstration Site (PDS) over three years monitoring >1,300 heifers clearly demonstrated a highly significant (p<0.001) relationship between proportion pregnant and weight. To achieve rates of more than 75% in high-percentage Brahman type heifers, live weights of at least 400 kg at pregnancy diagnosis (end of mating) was required. Ovarian scanning demonstrated a pre-mating live weight of approximately 340 kg was required for 80% of heifers to be at or near puberty. Neither pestivirus nor vibriosis were shown to be contributing factors in this study. Use of fewer, better bulls (<2% v 4%; selected on scrotal circumference and semen traits) significantly reduced business costs without reducing pregnancies. A 2% bull: female ratio was subsequently adopted by the host property across the entire breeding herd. This project’s findings are relevant to the entire northern beef industry and highlighted the importance of managing for high heifer growth prior to their first mating

Managing liveweight production from beef breeding herds

Introduction – asking the right question Too often when the question is asked, ‘How is your beef breeding herd going?’ the answer is a performance measure such as the proportion of cows pregnant or calves weaned. However, profit is primarily a function of live weight production, its value, and the cost of production. Therefore, the question should be ‘How many kilograms of live weight do you produce annually from this management group (herd) of breeding females per hectare?’ For example, if the farmer puts 100 tonne of cows in a paddock after completing pregnancy diagnosis of the herd then 12 months later how many tonnes of beef have been harvested from the herd (includes calves weaned and any cows and bulls sold). The role of veterinarians consulting to beef breeding farms should be to develop management strategies to improve herd live-weight production and identify opportunities to reduce cost of production. However, beef cattle farmers typically use veterinarians only to conduct pregnancy diagnosis, breeding soundness examination of bulls, and investigate outbreaks of disease or lower than expected reproductive performance

Unexpected Infection Spikes in a Model of Respiratory Syncytial Virus Vaccination

Respiratory Syncytial Virus (RSV) is an acute respiratory infection that infects millions of children and infants worldwide. Recent research has shown promise for the development of a vaccine, with a range of vaccine types now in clinical trials or preclinical development. We extend an existing mathematical model with seasonal transmission to include vaccination. We model vaccination both as a continuous process, applying the vaccine during pregnancy, and as a discrete one, using impulsive differential equations, applying pulse vaccination. We develop conditions for the stability of the disease-free equilibrium and show that this equilibrium can be destabilised under certain extreme conditions, even with 100% coverage using an (unrealistic) vaccine. Using impulsive differential equations and introducing a new quantity, the impulsive reproduction number, we showed that eradication could be acheived with 75% coverage, while 50% coverage resulted in low-level oscillations. A vaccine that targets RSV infection has the potential to significantly reduce the overall prevalence of the disease, but appropriate coverage is critica

Reproductive Ecology Of The Florida Scrub-Jay (Aphelocoma Coerulescens) On John F. Kennedy Space Center/Merritt Island National Wildlife Refuge: A Long-Term Study

From 1988 to 2002 we studied the breeding ecology of Florida Scrub-Jays (Aphelocoma coerulescens) on John F. Kennedy Space Center/Merritt Island National Wildlife Refuge. We examined phenology, clutch size, hatching failure rates, fledgling production, nest success, predation rates, sources egg and nestling mortality, and the effects of helpers on these measures. Nesting phenology was similar among sites. Mean clutch size at Titan was significantly larger than at HC or T4. Pairs with helpers did not produce larger clutches than pairs without helpers. Fledgling production at T4 was significantly greater than at HC and similar to Titan. Pairs with helpers at HC produced significantly more fledglings than pairs without helpers; helpers did not influence fledgling production at the other sites. Nest success at HC and Titan was low, 19% and 32% respectively. Nest success at T4 was 48% and was significantly greater than at HC. Average predation rates at all sites increased with season progression. Predation rates at all sight rose sharply by early June. The main cause of nest failure at all sites was predation, 93%

Use of satellite telemetry data, GIS, and HTML to create an interactive display of caribou movements

The use of animation clearly reveals the large annual variation in wintering areas and large differences in daily movement rates for this herd. This interactive display can be adapted for school groups, subsistence hunters, the general public, or scientists

Use of satellite telemetry to evaluate movements of caribou within subsistence hunting areas in northern Alaska

Caribou from the Teshekpuk Herd (TH) are an important subsistence resource for residents of Inupiaq villages in northern Alaska. In recent years the use of satellite telemetry has increased the understanding of the herd's annual movements and interactions with other herds. Most caribou of the TH are within the National Petroleum Reserve&mdash;Alaska (NPRA) throughout the year. The northeastern portion of NPRA has undergone two lease sales for oil and gas exploration, and lease sales are tentatively scheduled for the central/northwest portion of the NPRA in 2004. During 1990&mdash;1999, the movements of 27 caribou from the TH were tracked using satellite collars. We evaluated the proportion of time caribou were available to Inupiaq hunters by incorporating maps depicting subsistence-use areas for each of seven Inupiaq villages, and then examining seasonal and annual movements of caribou relative to those areas. By combining caribou locations with subsistence hunting areas, we were able to explore spatial and temporal patterns in caribou availability to subsistence hunters. This information is useful for managers to set appropriate hunting regulations and for devising sensible alternatives and mitigation of likely petroleum development in NPRA

Finding the ‘Sweet Spot’ for reproductive performance in north Australian beef herds

We know that nutrition has a dominating effect on the reproductive performance of beef breeding females, but the level of pasture utilisation required for optimal cow herd production in northern Australia is unknown. We are using existing datasets to: 1) quantify the effect of pasture utilisation rates on reproductive performance (pregnancy, lactating cows pregnant within four months, calf loss and weaning percentage); 2) improve the capacity of existing models to predict cow performance and economics of herd management; and 3) recommend management to improve cow herd performance, production and profitability while maintaining the land and pasture resource for different land types and regions in northern Australia

High prevalence of vitamin D deficiency in Cambodian women:A common deficiency in a sunny country

Recent studies have shown that in spite of being generally close to the equator; vitamin D deficiency is common in South East Asian countries. In order to quantify micronutrient status for women and children in Cambodia; a nationally-representative survey was conducted in 2014 linked to the Cambodian Demographic Health Survey. The countrywide median of 25(OH) D was, respectively, 64.9 and 91.1 nmol/L for mothers and children. Based on The Endocrine Society cutoffs (>50<75 nmol/L = insufficiency; <= 50 nmol/L = deficiency); 64.6% of mothers and 34.8% of their children had plasma vitamin D concentrations indicating insufficiency or deficiency. For deficiency alone, 29% of the mothers were found to be vitamin D deficient, but only 13.4% of children. Children who live in urban areas had a 43% higher rate of vitamin D insufficiency versus those who live in rural areas (OR; 1.434; 95% CI: 1.007; 2.041). However, such differences were not observed in their mothers. The high prevalence of vitamin D deficiency is likely in part due to lifestyle choices, including sun avoidance, increasingly predominant indoor work, and covered transport. These survey findings support the need for a broader national Cambodian study incorporating testing of adult men, adolescents and the elderly, and encompassing other parameters such as skeletal health. However, the data presented in this study already show significant deficiencies which need to be addressed and we discuss the benefit of establishing nationally-mandated food fortification programs to enhance the intake of vitamin D

Northern Australia beef fertility project: Cash Cow

The causes of poor reproductive performance in northern Australian beef herds are multi-factorial and uantification of the impact of individual factors on performance of breeding mobs is lacking. The reproductive performance of ~78,000 cows managed in 142 breeding mobs located on 72 commercial beef cattle properties was measured over three to four consecutive years (2008-11) using a crush-side electronic data capture system. Percentage of lactating cows pregnant within four months of calving, annual pregnancy rate, percentage foetal/calf loss between pregnancy diagnosis and weaning, and annual percentage of pregnant cows missing (mortality) were used to define performance, with the commercially achievable level of performance proposed as the performance of the 75th percentile mob or cow for each measure. Also, methods of estimating liveweight production from breeding herds were developed, and an achievable level determined for each country type. The impacts of 83 property, environmental, nutritional, management, and infectious disease factors on performance were investigated. The major factors affecting performance included country type, time of previous calving, wet season phosphorous status, cow body condition, hip-height, cow age class, cow reproductive history, severity of environmental conditions, and occurrence of mustering events around the time of calving. Producer/manager opinion that wild dogs were a problem, evidence of recent pestivirus infection and vibriosis were factors that did not contribute to the final model, but did significantly affect animal performance when present. A framework was developed for conducting economic analyses to assess the impact of factors affecting performance

Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma

Background Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brainstem tumor for which radiation is the only treatment. Case studies report a clinical response to ONC201 for patients with H3K27M-mutant gliomas. Oncoceutics (ONC201) is only available in the United States and Japan; however, in Germany, DIPG patients can be prescribed and dispensed a locally produced compound-ONC201 German-sourced ONC201 (GsONC201). Pediatric oncologists face the dilemma of supporting the administration of GsONC201 as conjecture surrounds its authenticity. Therefore, we compared GsONC201 to original ONC201 manufactured by Oncoceutics Inc. Methods Authenticity of GsONC201 was determined by high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy. Biological activity was shown via assessment of on-target effects, in vitro growth, proliferation, and apoptosis analysis. Patient-derived xenograft mouse models were used to assess plasma and brain tissue pharmacokinetics, pharmacodynamics, and overall survival (OS). The clinical experience of 28 H3K27M+ mutant DIPG patients who received GsONC201 (2017-2020) was analyzed. Results GsONC201 harbored the authentic structure, however, was formulated as a free base rather than the dihydrochloride salt used in clinical trials. GsONC201 in vitro and in vivo efficacy and drug bioavailability studies showed no difference compared to Oncoceutics ONC201. Patients treated with GsONC201 (n = 28) showed a median OS of 18 months (P = .0007). GsONC201 patients who underwent reirradiation showed a median OS of 22 months compared to 12 months for GsONC201 patients who did not (P = .012). Conclusions This study confirms the biological activity of GsONC201 and documents the OS of patients who received the drug; however, GsONC201 was never used as a monotherapy