A survey to evaluate the efficacy of virechana, basti and knee dhara in patients with Osteoarthritis of knee joint

Background: The objective of this study was to evaluate the role of Virechana (Arhtrox) followed by Kalbasti (14 in number), Knee dhara and Matrabastiin knee osteoarthritis patients.Methods: From OPD of Ayushakti Ayurveda Pvt. Ltd., 60 Patients suffering from knee Osteoarthritis (Janusandhigatavata) were selected randomly as per the inclusion and exclusion criteria. On the basis of specific criteria prepared. Group-I-(30 patients) received only Ayushakti herbs for Osteoarthritis, viz. Painmuktimj, Painmukti sandhical and Painmukti cream for LA Group-II-(30 patients) received Virechana (Arthrox), KalBastikrama (14 Bastis) and Knee dhara with oil followed by Matrabasti (60 ml) twice a week for 6 months along with Ayushakti herbs for Osteoarthritis. Each participant was in the study for 6 months. The entire study duration was 12 months.Result: About 87 patients were enrolled in the study of which 60 completed the study, 27 patients were drop out of the study, at the different stages of project mainly due to poor follow up. Significant reduction in pain was observed in Groups I and II as compared to the baseline (p <0.001) Pain scale (p <0.001).Conclusion: In this study, good relief was offered in knee joint pain, stiffness and mobility, and daily activities like standing, walking, and climbing. Painmukti mj, Painmukti cream and Painmukti Sandhical tablets are Anti-inflammatory, Analgesic but their efficacy can be increased with Virechana

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

A Retrospective Study of Clinical and Laboratory Profile of Dengue Fever in Tertiary Care Hospital, Wardha, Maharashtra, India

Dengue disease is caused by dengue virus which is a vector born viral infection. The prevalence of dengue has increased dramatically from past few decades. The clinical symptoms vary from asymptomatic to severe hemorrhagic fever leads to high morbidity and mortality. Method- This retrospective study was carried out during January 2019 to December 2019. The laboratory test was done by using J Mitra & Co on Day 1 of their visit to the hospital which shows NS1, IgM and IgG reactivity towards dengue fever. The clinical profile information data was collected from patient records. Out of 640 samples 62.18% (398) was positive. The percentage of positive males and females were 60.78%, 64.23% respectively. The highest prevalence of dengue infection was observed more in age group between 31-40 years (81.69%) and least prevalence in age group 71-80 years (36.36%). Most of the patients were positive for NS1Ag121 (30.4%) followed by IgM positive 87 (21.9%) & 59 (14.8%) positive for both IgM and NS1 Ag The highest number of infections was seen during October (75.8%) post monsoon season. All patients had a fever, followed by head ache (82%) and body pains (66.4%), 64.84% stayed in the hospital less than 5 days. In tropical and sub-tropical regions dengue is still a leading public health problem especially during rainy and post monsoon seasons. Both NS1 Ag and IgM detection in early acute phase has potential diagnostic value. So, to reduce mortality there need to initiate community-based cohort studies to predict the pace of dengue spread based on clinical presentation and laboratory findings during epidemics in India. Aedesaegypti is a common vector for transmission of DENV, CHIKV and ZIKV, so there is a need to screen for these infections in endemic areas