2 research outputs found
DEVELOPMENT OF UV-SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF IMATINIB MESYLATE (ITM) IN BULK AND FORMULATION
A simple and precise spectroscopic method for determination of Imatinib Mesylate in its bulk and tablet dosage forms has been developed and validated. This method based upon measurement of light absorption in UV region. The UV spectra of Imatinib Mesylate showed that maximum absorbance of light was observed at 281 nm and linearity was observed in the concentration range of 2-28ug/ml with correlation coefficient 0.999. The proposed method was validated as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.040468 (μg/ml) and 0.122263 (μg/ml) respectively by simple UV Spectroscopy