The presence of depression and anxiety do not distinguish between functional jerks and cortical myoclonus

INTRODUCTION: Functional movement disorders are accompanied by a high occurrence of psychopathology and cause serious impairments in quality of life. However, little is known about this in patients with functional jerks and no comparison has been made between patients with functional jerks and organic myoclonus. This case control study compares the occurrence of depression, anxiety and quality of life (HR-QoL) in patients with functional jerks and cortical myoclonus. METHODS: Patients with functional jerks and cortical myoclonus, consecutively recruited, were compared on self-rated anxiety (Beck Anxiety Inventory), depression (Beck Depression Inventory), health-related quality of life (RAND-36), and myoclonus severity (UMRS and CGI-S rating scales). RESULTS: Sixteen patients with functional jerks and 23 with cortical myoclonus were evaluated. There was no significant difference in depression (44% vs. 43%) or anxiety (44% vs. 47%) scores between groups. The HR-QoL was similarly impaired except that functional jerks patients reported significantly more pain (p < 0.05). Only in the functional jerks group myoclonus severity correlated with depression and anxiety. CONCLUSION: Depression and anxiety scores are high and do not discriminate between functional jerks and cortical myoclonus. Quality of life was equally impaired in both sub-groups, but pain was significantly worse in patients with functional jerks

Tachyonic preheating using 2PI-1/N dynamics and the classical approximation

We study the process of tachyonic preheating using approximative quantum equations of motion derived from the 2PI effective action. The O(N) scalar (Higgs) field is assumed to experience a fast quench which is represented by an instantaneous flip of the sign of the mass parameter. The equations of motion are solved numerically on the lattice, and the Hartree and 1/N-NLO approximations are compared to the classical approximation. Classical dynamics is expected to be valid, since the occupation numbers can rise to large values during tachyonic preheating. We find that the classical approximation performs excellently at short and intermediate times, even for couplings in the larger region currently allowed for the SM Higgs. This is reassuring, since all previous numerical studies of tachyonic preheating and baryogenesis during tachyonic preheating have used classical dynamics. We also compare different initializations for the classical simulations.Comment: 32 pages, 21 figures. Published version: Some details added, section added, references added, conclusions unchange

Conductance of single-atom platinum contacts: Voltage-dependence of the conductance histogram

The conductance of a single-atom contact is sensitive to the coupling of this contact atom to the atoms in the leads. Notably for the transition metals this gives rise to a considerable spread in the observed conductance values. The mean conductance value and spread can be obtained from the first peak in conductance histograms recorded from a large set of contact-breaking cycles. In contrast to the monovalent metals, this mean value for Pt depends strongly on the applied voltage bias and other experimental conditions, ranging from about 1 to 2.5 times 2e^2/h. We propose that the different results in part can be explained by the inclusion of hydrogen in the contacts. The bias dependence of the conductance is on the other hand due to the electron current that destabilizes monatomic Pt chains at high bias.Comment: 4 pages, 4 figure

A Current Induced Transition in atomic-sized contacts of metallic Alloys

We have measured conductance histograms of atomic point contacts made from the noble-transition metal alloys CuNi, AgPd, and AuPt for a concentration ratio of 1:1. For all alloys these histograms at low bias voltage (below 300 mV) resemble those of the noble metals whereas at high bias (above 300 mV) they resemble those of the transition metals. We interpret this effect as a change in the composition of the point contact with bias voltage. We discuss possible explanations in terms of electromigration and differential diffusion induced by current heating.Comment: 5 pages, 6 figure

Magnetic susceptibilities of diluted magnetic semiconductors and anomalous Hall-voltage noise

The carrier spin and impurity spin densities in diluted magnetic semiconductors are considered using a semiclassical approach. Equations of motions for the spin densities and the carrier spin current density in the paramagnetic phase are derived, exhibiting their coupled diffusive dynamics. The dynamical spin susceptibilities are obtained from these equations. The theory holds for p-type and n-type semiconductors doped with magnetic ions of arbitrary spin quantum number. Spin-orbit coupling in the valence band is shown to lead to anisotropic spin diffusion and to a suppression of the Curie temperature in p-type materials. As an application we derive the Hall-voltage noise in the paramagnetic phase. This quantity is critically enhanced close to the Curie temperature due to the contribution from the anomalous Hall effect.Comment: 18 pages, 1 figure include

Chern-Simons production during preheating in hybrid inflation models

We study the onset of symmetry breaking after hybrid inflation in a model having the field content of the SU(2) gauge-scalar sector of the standard model, coupled to a singlet inflaton. This process is studied in (3+1)-dimensions in a fully non-perturbative way with the help of lattice techniques within the classical approximation. We focus on the role played by gauge fields and, in particular, on the generation of Chern-Simons number. Our results are shown to be insensitive to the various cut-offs introduced in our numerical approach. The spectra preserves a large hierarchy between long and short-wavelength modes during the whole period of symmetry breaking and Chern-Simons generation, confirming that the dynamics is driven by the low momentum sector of the theory. We establish that the Chern-Simons production mechanism is associated with local sphaleron-like structures. The corresponding sphaleron rates are of order 10^{-5} m^4, which, within certain scenarios of electroweak baryogenesis and a (not unnaturally large) additional source of CP violation, could explain the present baryon asymmetry of the universe.Comment: 28 pages, 15 figures, ReVTeX. With minor corrections, version to appear in Phys. Rev.

Relation between coronary plaque composition assessed by intravascular ultrasound virtual histology and myocardial ischemia assessed by quantitative flow ratio

Coronary plaque composition may play an important role in the induction of myocardial ischemia. Our objective was to further clarify the relation between coronary plaque composition and myocardial ischemia in patients with chest pain symptoms. The study population consisted of 103 patients who presented to the outpatient clinic or emergency department with chest pain symptoms and were referred for diagnostic invasive coronary angiography. Intravascular ultrasound virtual histology was used for the assessment of coronary plaque composition. A noncalcified plaque was defined as a combination of necrotic core and fibrofatty tissue. Quantitative flow ratio (QFR), which is a coronary angiography-based technique used to calculate fractional flow reserve without the need for hyperemia induction or for a pressure wire, was used as the reference standard for the evaluation of myocardial ischemia. Coronary artery plaques with QFR of ≤0.80 were considered abnormal—that is, ischemia-generating. In total, 149 coronary plaques were analyzed, 21 of which (14%) were considered abnormal according to QFR. The percentage of noncalcified tissue was significantly higher in plaques with abnormal QFR (38.2 ± 6.5% vs 33.1 ± 9.0%, p = 0.014). After univariable analysis, both plaque load (odds ratio [OR] per 1% increase 1.081, p Cardiolog

Real‑world nudging, pricing, and mobile physical activity coaching was insufficient to improve lifestyle behaviours and cardiometabolic health: the Supreme Nudge parallel cluster‑randomised controlled supermarket trial

Background Context-specific interventions may contribute to sustained behaviour change and improved health outcomes. We evaluated the real-world effects of supermarket nudging and pricing strategies and mobile physical activity coaching on diet quality, food-purchasing behaviour, walking behaviour, and cardiometabolic risk markers.Methods This parallel cluster-randomised controlled trial included supermarkets in socially disadvantaged neighbourhoods across the Netherlands with regular shoppers aged 30–80 years. Supermarkets were randomised to receive co-created nudging and pricing strategies promoting healthier purchasing (N = 6) or not (N = 6). Nudges targeted 9% of supermarket products and pricing strategies 3%. Subsequently, participants were individually randomised to a control (step counter app) or intervention arm (step counter and mobile coaching app) to promote walking. The primary outcome was the average change in diet quality (low (0) to high (150)) over all follow-up time points measured with a validated 40-item food frequency questionnaire at baseline and 3, 6, and 12 months. Secondary outcomes included healthier food purchasing (loyalty card-derived), daily step count (step counter app), cardiometabolic risk markers (lipid profile and HbA1c via finger prick, and waist circumference via measuring tape), and supermarket customer satisfaction (questionnaire-based: very unsatisfied (1) to very satisfied (7)), evaluated using linear mixed-models. Healthy supermarket sales (an exploratory outcome) were analysed via controlled interrupted time series analyses.Results Of 361 participants (162 intervention, 199 control), 73% were female, the average age was 58 (SD 11) years, and 42% were highly educated. Compared to the control arm, the intervention arm showed no statistically significant average changes over time in diet quality (β − 1.1 (95% CI − 3.8 to 1.7)), percentage healthy purchasing (β 0.7 ( − 2.7 to 4.0)), step count (β − 124.0 (− 723.1 to 475.1), or any of the cardiometabolic risk markers. Participants in the intervention arm scored 0.3 points (0.1 to 0.5) higher on customer satisfaction on average over time. Supermarket-level sales were unaffected (β − 0.0 (− 0.0 to 0.0)).Conclusions Co-created nudging and pricing strategies that predominantly targeted healthy products via nudges were unable to increase healthier food purchases and intake nor improve cardiometabolic health. The mobile coaching intervention did not affect step count. Governmental policy measures are needed to ensure more impactful supermarket modifications that promote healthier purchases

Changes in perceived peripersonal space following the rubber hand illusion

Peripersonal space (PPS), the region immediately surrounding the body is essential for bodily protection and goal directed action. Previous studies have suggested that the PPS is anchored to one’s own body and in the current study we investigated whether the PPS could be modulated by changes in perceived body ownership. While theoretically important, this anchoring can also have implications for patients with altered body perception. The rubber hand illusion (RHI) is a way to manipulate body ownership. We hypothesized that after induction of a left hand RHI, the perceived space around the body shifts to the right. Sixty-five participants performed a landmark task before and after a left hand RHI. In the landmark task, participants had to determine whether a vertical landmark line was left or right from the center of a horizontal screen. One group of the participants was exposed to synchronous stroking, the other group experienced asynchronous stroking. Results showed a shift in space to the right (e.g. away from the own arm), but only for the ‘synchronous stroking’ group. These results suggest that the relevant action space becomes linked to the fake hand. Critically, subjective ownership experience did not correlate with this shift, but proprioceptive drift did. This suggests that multisensory integration of bodily information drives this shift in space around the body and not feelings of ownership

Towards an Asymptotic-Safety Scenario for Chiral Yukawa Systems

We search for asymptotic safety in a Yukawa system with a chiral $U(N_L)_L\otimes U(1)_R$ symmetry, serving as a toy model for the standard-model Higgs sector. Using the functional RG as a nonperturbative tool, the leading-order derivative expansion exhibits admissible non-Ga\ssian fixed-points for $1 \leq N_L \leq 57$ which arise from a conformal threshold behavior induced by self-balanced boson-fermion fluctuations. If present in the full theory, the fixed-point would solve the triviality problem. Moreover, as one fixed point has only one relevant direction even with a reduced hierarchy problem, the Higgs mass as well as the top mass are a prediction of the theory in terms of the Higgs vacuum expectation value. In our toy model, the fixed point is destabilized at higher order due to massless Goldstone and fermion fluctuations, which are particular to our model and have no analogue in the standard model.Comment: 16 pages, 8 figure