25 research outputs found

    Invasive Non-typhoidal Salmonella Infections in Asia: Clinical Observations, Disease Outcome and Dominant Serovars from an Infectious Disease Hospital in Vietnam.

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    Invasive non-typhoidal Salmonella (iNTS) infections are now a well-described cause of morbidity and mortality in children and HIV-infected adults in sub-Saharan Africa. In contrast, the epidemiology and clinical manifestations of iNTS disease in Asia are not well documented. We retrospectively identified >100 cases of iNTS infections in an infectious disease hospital in Southern Vietnam between 2008 and 2013. Clinical records were accessed to evaluate demographic and clinical factors associated with iNTS infection and to identify risk factors associated with death. Multi-locus sequence typing and antimicrobial susceptibility testing was performed on all organisms. Of 102 iNTS patients, 71% were HIV-infected, >90% were adults, 71% were male and 33% reported intravenous drug use. Twenty-six/92 (28%) patients with a known outcome died; HIV infection was significantly associated with death (p = 0.039). S. Enteritidis (Sequence Types (ST)11) (48%, 43/89) and S. Typhimurium (ST19, 34 and 1544) (26%, 23/89) were the most commonly identified serovars; S. Typhimurium was significantly more common in HIV-infected individuals (p = 0.003). Isolates from HIV-infected patients were more likely to exhibit reduced susceptibility against trimethoprim-sulfamethoxazole than HIV-negative patients (p = 0.037). We conclude that iNTS disease is a severe infection in Vietnam with a high mortality rate. As in sub-Saharan Africa, HIV infection was a risk factor for death, with the majority of the burden in this population found in HIV-infected adult men

    Sigma phase in nickel based superalloys

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    Paper from BCA Spring Conference 1991SIGLEAvailable from British Library Document Supply Centre- DSC:8019.3153(RR-PNR--90871) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism

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    The application of CALPHAD calculations to NI-based superalloys

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    Presented at the 9th Conference on superalloys, Seven Springs, September 2000Available from British Library Document Supply Centre-DSC:8019.322(92761) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

    Heat treatment of a melt spun Fe_7_0Cr_1_8Mo_2B_1_0 alloy

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    Appears as an article in Journal of non-crystalline solids 1991 v. 127 p. 273-286Available from British Library Document Supply Centre- DSC:8019.3153(RR-PNR--90877) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

    Problems in residual stress determination for thick components

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    Paper presented at the 'International Conference on Residual Stress', Oxford, UK, July 2000Available from British Library Document Supply Centre-DSC:8019.322(92748) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

    Problems in residual stress determination for thick components

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    Paper presented at the 'International Conference on Residual Stress', Oxford, UK, July 2000Available from British Library Document Supply Centre-DSC:8019.322(92748) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo
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