Bony sclerosis and the battered child

A case of child battering in a four monthold infant is presented. In additional to typical physical and radiographic findings isolated sclerosis of the left tibia is described. Diffuse bony sclerosis in battered children has been proposed as evidence for an underlying metaphyseal fragility. Similar sclerosis in an isolated bone in our case suggests that the diffuse bony sclerosis seen in some of these battered children may reflect a more widespread posttraumatic change and not a basic metabolic defect. A radionuclide bone scan was also normal in this patient.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46800/1/256_2004_Article_BF00364627.pd

Iodixanol Pharmacokinetics in Children

The objective of this report was to study the elimination pharmacokinetics of iodixanol in children. Iodixanol (V isipaque ®, Nycomed Inc., Wayne, PA, USA) is a new iso-osmolar iodinated radiocontrast agent. We hypothesized that elimination of this agent would be dependent on age-related differences in renal clearance. Seven centers enrolled 43 patients. Cardiac catheterization was performed in 41 patients and cranial computed tomography in 2. Patients were entered into 5 age groups: newborn to 6 months of age that is comparable to normal adults. Prolonged elimination in children <6 months of age is related to renal immaturity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42384/1/246-22-3-223_10220223.pd