Evaluation of the economic benefit of increasing the qualification of workers at the Department of Medical Technology in Břeclav Hospital

Cílem práce bylo analyzovat, zda zvýšením kvalifikace zaměstnance OZT lze dosáhnout přínosu pro nemocnici. Pomocí modelu, ve kterém je společností Linet s.r.o. proškolen pracovník na provádění BTK u lůžek běžné i intenzivní péče. Metodou CMA byly sumarizovány náklady na provádění BTK externím dodavatelem a vlastními silami proškoleným pracovníkem. Z výsledků jasně vyplynulo, že při provádění BTK vlastními silami u lůžek pro běžnou péči při 223ks se poměrně razantně snížily náklady o 212 251 Kč a to i při potřebě nákupu vybavení potřebného k provádění těchto činností. Snížené náklady platí i při provádění oprav. Naopak u lůžek intenzivní péče v počtu 11kusů náklady na provádění BTK vlastními silami převyšují náklady na provádění externím dodavatelem. Metodou BIA byl analyzován dopad na rozpočet a doporučen model provádění BTK vlastními silami na lůžka běžné péče. Analýza citlivosti ukázala, že již při 12ks lůžek pro intenzivní péči jsou náklady vyrovnané.The aim of this thesis was to analyze, whether the increase in qualification of a DMT employee may benefit the Hospital. This analysis was executed using the model in which Linet s.r.o. trains an employee for Technical Safety Monitoring performance of regular and intensive care hospital beds. The costs of Technical Safety Monitoring performed by an external worker and internal trained worker were summarized by the CMA method. The results indicated that the costs of Technical Safety Monitoring of 223 regular care beds decreased by CZK 212 251 when performed by an internal worker even after buying equipment needed for the Technical Safety Monitoring. The costs of repairs decreased as well. On the other hand the costs of Technical Safety Monitoring of 11 intensive care beds performed by an internal worker exceeded the costs of Technical Safety Monitoring of these beds performed by an external supplier. The BIA method was used to analyze impact on the budget and the model of Technical Safety Monitoring performance of regular care beds by internal worker was recommended. The sensitivity analysis indicated that with 12 intensive care beds the costs are equal

Electrochemical Estimations of the Gold Nanoparticle Size Effect on Cysteine-Gold Oxidation,

Gold nanoparticles are interesting for nanobiomedical applications, such as for drug delivery and as diagnostic imaging contrast agents. However, their stability and reactivity in-vivo are influenced by their surface properties and size. Here, we investigate the electrochemical oxidation of differently sized citrate-coated gold nanoparticles in the presence and absence of L-cysteine, a thiol-containing amino acid with high binding affinity to gold. We found that smaller sized (5, 10 nm) gold nanoparticles were significantly more susceptible to electrochemical L-cysteine interactions and/or L-cysteine-facilitated gold oxidation than larger (20, 50 nm) sized gold nanoparticles, both for the same mass and nominal surface area, under the conditions investigated (pH 7.4, room temperature, stagnant solutions, and scan rates of 0.5 to 450 mV s−1). The electrochemical measurements of drop-casted gold nanoparticle suspensions on paraffin-impregnated graphite electrodes were susceptible to the quality of the electrode. Increased cycling resulted in irreversible oxidation and detachment/oxidation of gold into solution. Our results suggest that L-cysteine-gold interactions are stronger for smaller nanoparticles

Electrochemical estimations of the gold nanoparticle size effect on cysteine-gold oxidation

Gold nanoparticles are interesting for nanobiomedical applications, such as for drug delivery and as diagnostic imaging contrast agents. However, their stability and reactivity in-vivo are influenced by their surface properties and size. Here, we investigate the electrochemical oxidation of differently sized citrate-coated gold nanoparticles in the presence and absence of L-cysteine, a thiol-containing amino acid with high binding affinity to gold. We found that smaller sized (5, 10 nm) gold nanoparticles were significantly more susceptible to electrochemical L-cysteine interactions and/or L-cysteine-facilitated gold oxidation than larger (20, 50 nm) sized gold nanoparticles, both for the same mass and nominal surface area, under the conditions investigated (pH 7.4, room temperature, stagnant solutions, and scan rates of 0.5 to 450 mV s−1). The electrochemical measurements of drop-casted gold nanoparticle suspensions on paraffin-impregnated graphite electrodes were susceptible to the quality of the electrode. Increased cycling resulted in irreversible oxidation and detachment/oxidation of gold into solution. Our results suggest that L-cysteine-gold interactions are stronger for smaller nanoparticles