2 research outputs found
Colorimetric Determination of Cefadroxil and Ceftriazone in Pharmaceutical Dosage Forms
Purpose: To develop a simple, rapid and selective method for the
spectrophotometric determination of cefadroxil and ceftriaxone using 1,
2-napthaquinone-4-sulfonic acid sodium. Methods: The method was based
on the derivatization of cefadroxil and ceftriaxone with 1,
2naphthaquinone-4-sulfonic acid sodium in alkaline medium to yield
orange-colored products. Results: The reaction products of cefadroxil
and ceftriaxone at their respective λ max of 475 and 480 nm showed
linearity in the concentration range of 10 -100 and 25 -175 µg/ml,
respectively. Relative standard deviations of 0.82 % for cefadroxil and
0.95 % for ceftriaxone were obtained. Recoveries of cefadroxil tablets
and ceftriaxone injection were in the range of 100.66 ± 0.98 and
99.38 ± 0.84 %, respectively. Conclusion: Recovery studies gave
satisfactory results indicating that none of the major
additives/excipients interfered with the assay method. Therefore, the
proposed method is simple, rapid, precise and convenient for the assay
of cefadroxil and ceftriaxone in commercial preparations