1 research outputs found
Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) due
to the acquisition of resistance to current antimicrobials pose a serious
challenge for therapy, and new measures to treat and prevent this infectious
pathogen are of crucial importance. Plant essential oils (EOs) and their
constituents are promising agents with antimicrobial properties. The aim of
this study was to evaluate the antistaphylococcal effect of essential oils
from Salvia officinalis using the broth-microdilution method. Essential oils
of S. officinalis were isolated from the same individual, but at different
life stages - young and old leaves. The effects of combinations of
sub-inhibitory concentrations of oil and different antibiotics were evaluated
by the checkerboard method. The results, expressed as the fractional
inhibitory concentration (FIC) and index (FICI), indicate that the essential
oil isolated from young leaves potentiated the inhibitory effect of
antibiotics against tested MRSA strains. [Projekat Ministarstva nauke
Republike Srbije, br. 173021