Production of cytokines by mononuclear cells of hypertrophic adenoids in children with otitis media with effusion

Hypertrophic adenoids with otitis media with effusion is a common infectious disease and presenta serious otological problem in children. Cytokines, potent inflammatory mediators, play important role in theinitiation of immunological response in otitis media. Adenoids excised due to hypertrophy with or without chronicotitis media with effusion were used to isolate mononuclear cells. Secretion of cytokines by non-stimulated andPHA-stimulated cells was determined by specific ELISAs. We found a significant increase in the production ofIL-5 and TNF-a secreted by adenoidal cells of children with otitis media with effusion compared to group withhypertrophic adenoids. No differences were found in the secretion of IL-8, IL-6, and IL-10 between these twogroups of patients. Our results suggest a difference between the immunological responses in the course of hypertrophicadenoids with otitis media as compared to hypertrophic adenoids

The effect of balanced development idea on the quality of life of inhabitants in selected municipalities of the Silesian province

Balanced development, Quality of life, Municipality management, Local government, Silesia,