Direct observation by resonant tunneling of the B^+ level in a delta-doped silicon barrier

We observe a resonance in the conductance of silicon tunneling devices with a delta-doped barrier. The position of the resonance indicates that it arises from tunneling through the B^+ state of the boron atoms of the delta-layer. Since the emitter Fermi level in our devices is a field-independent reference energy, we are able to directly observe the diamagnetic shift of the B^+ level. This is contrary to the situation in magneto-optical spectroscopy, where the shift is absorbed in the measured ionization energy.Comment: submitted to PR

Perceived and Actual Breast Cancer Risk

Perceived risk can influence health behaviors. Studies using various populations and breast cancer risk bias assessment methods have identified both risk over- and underestimation. Among 1803 women in primary care settings, 47 percent were at average epidemiologic risk (Gail-calculated relative risk ±50 percent of age-adjusted population average) and 55 percent perceived themselves to be at average risk (compared to same-age others) but there were mismatches or ‘biases’: 31 percent underestimated personal risk; 26 percent overestimated. Multiple logistic regression revealed that smokers were more likely to overestimate risk. Overestimation decreased with more education. Mammography use did not independently predict perception bias but, among never-screened women aged over 40 years, those contemplating mammograms were most likely to overestimate risk; precontemplators were most likely to underestimate. Implications for research and intervention are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66881/2/10.1177_135910539800300203.pd

Jacobi-like bar mode instability of relativistic rotating bodies

We perform some numerical study of the secular triaxial instability of rigidly rotating homogeneous fluid bodies in general relativity. In the Newtonian limit, this instability arises at the bifurcation point between the Maclaurin and Jacobi sequences. It can be driven in astrophysical systems by viscous dissipation. We locate the onset of instability along several constant baryon mass sequences of uniformly rotating axisymmetric bodies for compaction parameter $M/R = 0-0.275$. We find that general relativity weakens the Jacobi like bar mode instability, but the stabilizing effect is not very strong. According to our analysis the critical value of the ratio of the kinetic energy to the absolute value of the gravitational potential energy $(T/|W|)_{\rm crit}$ for compaction parameter as high as 0.275 is only 30% higher than the Newtonian value. The critical value of the eccentricity depends very weakly on the degree of relativity and for $M/R=0.275$ is only 2% larger than the Newtonian value at the onset for the secular bar mode instability. We compare our numerical results with recent analytical investigations based on the post-Newtonian expansion.Comment: 15 pages, 8 figures, submitted to Phys. Rev.

X-Ray Polarization of Solar Flares Measured with Rhessi

The degree of linear polarization in solar flares has not yet been precisely determined despite multiple attempts to measure it with different missions. The high energy range in particular has very rarely been explored, due to its greater instrumental difficulties. We approached the subject using the Reuven Ramaty High Energy Spectroscopic Imager (RHESSI) satellite to study 6 X-class and 1 M-class flares in the energy range between 100 keV and 350 keV. Using RHESSI as a polarimeter requires the application of strict cuts to the event list in order to extract those photons that are Compton scattered between two detectors. Our measurements show polarization values between 2% and 54%, with errors ranging from 10% to 26% in 1 sigma level. In view of the large uncertainties in both the magnitude and direction of the polarization vector, the results can only reject source models with extreme properties.Comment: 26 pages, 11 figures, accepted for publication by Solar Physic

Ultra-long-acting removable drug delivery system for HIV treatment and prevention

Non-adherence to medication is an important health care problem, especially in the treatment of chronic conditions. Injectable long-acting (LA) formulations of antiretrovirals (ARVs) represent a viable alternative to improve adherence to HIV/AIDS treatment and prevention. However, the LA-ARV formulations currently in clinical trials cannot be removed after administration even if adverse events occur. Here we show an ultra-LA removable system that delivers drug for up to 9 months and can be safely removed to stop drug delivery. We use two pre-clinical models for HIV transmission and treatment, non-human primates (NHP) and humanized BLT (bone marrow/liver/thymus) mice and show a single dose of subcutaneously administered ultra-LA dolutegravir effectively delivers the drug in both models and show suppression of viremia and protection from multiple high-dose vaginal HIV challenges in BLT mice. This approach represents a potentially effective strategy for the ultra-LA drug delivery with multiple possible therapeutic applications