Best supportive care for idiopathic pulmonary fibrosis: Current gaps and future directions

Best supportive care (BSC) is generally defined as all the interventions and the multiprofessional approach aimed to improve and optimise quality of life (QoL) in patients affected by progressive diseases. In this sense, it excludes and might be complementary to other interventions directly targeting the disease. BSC improves survival in patients with different types of cancer. Patients with idiopathic pulmonary fibrosis (IPF) experience a vast range of symptoms during the natural history of the disease and might have a beneficial effect of BSC interventions. This review highlights the current evidence on interventions targeting QoL and gaps for the clinical assessment of BSC in the treatment of IPF patients. Very few interventions to improve QoL or improve symptom control are currently supported by well-designed studies. Sound methodology is paramount in evaluating BSC in IPF, as well as the use of validated tools to measure QoL and symptom control in this specific group of patients

Transmission of 240 Gb/s PM-RZ-D8PSK over 320 km in 10 Gb/s NRZ-OOK WDM System

We present the first demonstration of 40 Gbaud PM-RZ-D8PSK and its successful transmission in a 100 GHz-spaced 10 Gb/s NRZ-OOK WDM system over a 320-km transmission link along with the studies of WDM nonlinear crosstalk

Comparison of 112-Gb/s PM-RZ-DQPSK and PM-RZ-D8PSK in Terms of OSNR Requirement and Transmission Impairments

We have, for the first time, experimentally investigated112-Gb/s polarization-multiplexed return-to-zero differential8-ary phase-shift keying (PM-RZ-D8PSK) with differentialdetection in terms of optical signal-to-noise ratio requirement,group velocity dispersion (GVD), and differential group delay(DGD) tolerances, together with a direct comparison with PM-RZdifferential quadrature phase-shift keying at equivalent bit rate.The results indicate higher tolerances with respect to GVD andDGD but lower receiver sensitivity in the case of PM-RZ-D8PS

Benefits of Joint Statistics in MLSD-Equalized Transmission

We experimentally investigate and quantify performance improvement, accounting for multiple bit intervals\u27 joint statistics in filtered equalized on-off keying OC-192 fiber-optic links relying on Viterbi-algorithm-based sequence detection. We demonstrate that the penalty associated with narrow filtering can be alleviated for the most part with an appropriate detection approach

Benefits of Joint Statistics in MLSD-Equalized Transmission

We experimentally investigate and quantify performance improvement, accounting for multiple bit intervals\u27 joint statistics in filtered equalized on-off keying OC-192 fiber-optic links relying on Viterbi-algorithm-based sequence detection. We demonstrate that the penalty associated with narrow filtering can be alleviated for the most part with an appropriate detection approach