Job Satisfaction among Malaysian Pharmacists

This study was carried out to gauge the level of job satisfaction among pharmacists in Malaysia. Surveys forms developed after referring to published studies, were mailed to 1700 pharmacist. Analysis of responses from 405 respondents revealed significant differences in job satisfaction with age, position held and monthly salary. Pharmacist within the age group of 26 to 35 were less satisfied with their work as compared to the other pharmacist. A monthly salary of more than RM8000 and prospects of promotion within an organization contributed to a high level of satisfaction among pharmacist. Sector of work and length of service did not appear to influence job satisfaction. Further analysis indicated that motivator factors and hygiene factors had a significant influence on job satisfaction, whereas job stress contributed toward dissatisfaction at work. The results of the study supported Herzberg’s theory, which states the motivator factors were far more important than hygiene factors in providing job satisfaction. From this study, it appeared that more than 50% of the pharmacists who responded had at least a moderate level of job satisfaction. However, efforts can be taken by employers to further improve job satisfaction among Malaysian pharmacists

Genetic Biomarkers as Predictors of Response to Tocilizumab in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Rheumatoid arthritis (RA) is a lifelong, debilitating disease which incredibly impacts a patient’s quality of life if not treated to the optimal target. The clinical response of tocilizumab, an interleukin-6 (IL-6) inhibitor, is associated with several gene polymorphisms, particularly targeting the IL-6 pathway. This systematic review and meta-analysis seeks to investigate genetic biomarkers that predict the treatment outcome of tocilizumab therapy in RA patients. After evaluating the quality of retrieved records, five studies were chosen to carry out a quantitative synthesis involving 591 participants. We analysed genetic markers of IL-6R single nucleotide polymorphism (SNP)s rs12083537, rs2228145 and rs4329505, FCGR3A, CD69, GALNT18 and FCGR2A. A plausible finding based on meta-analysis revealed that RA patients with homozygous AA genotype for rs12083537 polymorphism of the IL-6R gene demonstrate a better response to TCZ treatment as opposed to homozygous and heterozygous patients with the G allele. Nonetheless, limitations in evaluating the available studies by meta-analysis include a lack of studies with dissimilarities in study design and outcome definitions, small sample sizes with low statistical power and heterogeneity of cohorts, a restricted the number of tested SNPs and small effects for the selected variants. Inconsistent finding remains as a great challenge to forge ahead towards personalised medicine for RA management