Interview by Chan, Grace Siu Wai

The interviewee (Anita) is my mother who spent her childhood in a boat. She was borned in a fishing family. It is a big family that includes ten people in total, her parents, two elder brothers, five younger brothers (it should be six in total actually, but one of them died because of sickness) and one younger sister. Her family was a poor family, as what she described, we could earn the breakfast but dinner or the dinner but breakfast . Therefore, Anita did not have chance to go to the school (so was her eldest brother), besides, she had to take care of her younger siblings. The only entertainment or hobby for her was making clothes and seeing films and she learned clothing by herself. Her friends were those girls from other boats but they have not contacted each other after marriages. They could not contact each other since they didn\u27t have telephones that time. Compared to her younger sister and other siblings those who had studies she felt they were luckier. She has not blamed her parents this since she felt her parents had worked very hard already. There was once Anita\u27s eldest brother dropped the fishing founding carelessly back into the sea, she tried very hard to jump into the sea to get them back, this event was vivid in Anita\u27s mind. Overall, Anita could not say whether her childhood a happy one or not, she said there was nothing she could regards as happy or unhappy

Error Free Perfect Secrecy Systems

Shannon's fundamental bound for perfect secrecy says that the entropy of the secret message cannot be larger than the entropy of the secret key initially shared by the sender and the legitimate receiver. Massey gave an information theoretic proof of this result, however this proof does not require independence of the key and ciphertext. By further assuming independence, we obtain a tighter lower bound, namely that the key entropy is not less than the logarithm of the message sample size in any cipher achieving perfect secrecy, even if the source distribution is fixed. The same bound also applies to the entropy of the ciphertext. The bounds still hold if the secret message has been compressed before encryption. This paper also illustrates that the lower bound only gives the minimum size of the pre-shared secret key. When a cipher system is used multiple times, this is no longer a reasonable measure for the portion of key consumed in each round. Instead, this paper proposes and justifies a new measure for key consumption rate. The existence of a fundamental tradeoff between the expected key consumption and the number of channel uses for conveying a ciphertext is shown. Optimal and nearly optimal secure codes are designed.Comment: Submitted to the IEEE Trans. Info. Theor

Application of tri-colour, dual fusion fluorescence in situ hybridization (FISH) system for the characterization of BCR-ABL1 fusion in chronic myelogenous leukaemia (CML) and residual disease monitoring

<p>Abstract</p> <p>Background</p> <p>We studied the application of the <it>BCR-ABL1 </it>+ 9q34 tri-colour dual fusion fluorescence <it>in situ </it>hybridization (FISH) system in the characterization of fusion signal pattern and the monitoring of residual disease in chronic myelogenous leukaemia (CML). The signal constellation on metaphases with the tri-colour dual fusion system was defined. The knowledge of various signal patterns obtained from the different genetic rearrangements was further applied to the analysis of hybridization signals on interphase nuclei.</p> <p>Methods</p> <p><it>BCR-ABL1 </it>dual colour, dual fusion FISH (D-FISH) was performed on diagnostic samples of 22 CML patients. The tri-colour FISH system was performed on cases that showed aberrant signal patterns other than the classical 1 green (G) 1 orange (O) 2 fusions (F). Using the aqua band-pass filter, random signal overlap in interphase nuclei would be indicated by the presence of an aqua signal (<it>ASS1</it>), while genuine fusion was represented by the absence of the <it>ASS1 </it>signal.</p> <p>Results</p> <p>Using the D-FISH system, the signal patterns could be categorized into 4 groups: group 1 (n = 17) showed the classical 1G1O2F; group 2 (n = 2) showed 2G1O1F indicating <it>ABL1 </it>deletion; group 3 (n = 1) showed 1G2O1F indicating <it>BCR </it>deletion; group 4 (n = 2) with 1G1O1F indicating reciprocal <it>ABL1-BCR </it>deletion. The tri-colour dual fusion system correlated with the D-FISH system for cases with der(9) deletion. The added aqua-labelled <it>ASS1 </it>probe was useful in differentiating random signal overlap from genuine <it>BCR-ABL1 </it>fusion in the interphase cells (group 4).</p> <p>Conclusion</p> <p>Although the D-FISH probe was valuable in establishing the different patterns of aberrant signals and monitoring patients with the classic 2-fusion signals in CML, the tri-colour dual fusion probe should be used for patients with der(9) deletion to monitor response to treatment.</p

How students cope with part-time study

This study provides a qualitative test and illustration of a model of how students cope with the demands of part-time study. The model shows that students who are successful in finding the time to complete the requirements of part-time courses do so by adopting three mechanisms; sacrifice, support and the negotiation of arrangements. All three mechanisms operate in four domains, namely work, family, social lives and the self. The mechanisms and domains were related together in a three by four matrix. Data to verify and illuminate the model were gathered by the researchers through an on-line forum discussion on the topic of coping with part-time study. The researchers themselves were studying part-time in a course called Adult Education and Professional Development. Analysis of the data showed that the work domain was very important but little adaptation was possible. The family was seen as the most important domain and all three mechanisms were used. Time was commonly found for part-time study by sacrificing social lives. The self-domain was interpreted as important in establishing motivation and self-determination