Positional, Reorientational and Bond Orientational Order in DNA Mesophases

We investigate the orientational order of transverse polarization vectors of long, stiff polymer molecules and their coupling to bond orientational and positional order in high density mesophases. Homogeneous ordering of transverse polarization vector promotes distortions in the hexatic phase, whereas inhomogeneous ordering precipitates crystalization of the 2D sections with different orientations of the transverse polarization vector on each molecule in the unit cell. We propose possible scenarios for going from the hexatic phase, through the distorted hexatic phase to the crystalline phase with an orthorhombic unit cell observed experimentally for the case of DNA.Comment: 4 pages, 2 figure

Slip Behavior and Hardness Indentations in MnSe and MnSe-MnS Solid Solutions

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65510/1/j.1151-2916.1969.tb11957.x.pd

Near-infrared imaging of FSC 10214+4724 with the W. M. Keck Telescope

Near-infrared observations of the z = 2.286 IRAS source FSC 10214+4724, made with the near-infrared camera on the W. M. Keck Telescope, are reported. Deep broad-band images at 2.15 and 1.27 micrometers, and narrow-band images at 2.165 and 2.125 µm with 0.”6 to 0.”9 seeing show that FSC 10214+4724 consists of at least three distinct components in a compact group of galaxies. The source of the infrared luminosity appears to be in a strongly interacting galaxy that has a luminosity of ~100 times that of a present-day L* galaxy. The interaction suggests and 'age' of this galaxy of ≃ 10^9 yr. The Hα emission is resolved as a source of diameter ≃ 5 kpc, suggesting that a starburst contributes to the observed Hα emission. There is an excess of objects in the FSC 10214+4724 field that could represent galaxies in an associated cluster

Annihilation Emission from the Galactic Black Hole

Both diffuse high energy gamma-rays and an extended electron-positron annihilation line emission have been observed in the Galactic Center (GC) region. Although X-ray observations indicate that the galactic black hole Sgr A$^*$ is inactive now, we suggest that Sgr A$^*$ can become active when a captured star is tidally disrupted and matter is accreted into the black hole. As a consequence the galactic black hole could be a powerful source of relativistic protons. We are able to explain the current observed diffuse gamma-rays and the very detailed 511 keV annihilation line of secondary positrons by $p-p$ collisions of such protons, with appropriate injection times and energy. Relativistic protons could have been injected into the ambient material if the black hole captured a 50M$_\odot$ star at several tens million years ago. An alternative possibility is that the black hole continues to capture stars with $\sim$1M$_\odot$ every hundred thousand years. Secondary positrons produced by $p-p$ collisions at energies \ga 30 MeV are cooled down to thermal energies by Coulomb collisions, and annihilate in the warm neutral and ionized phases of the interstellar medium with temperatures about several eV, because the annihilation cross-section reaches its maximum at these temperatures. It takes about ten million years for the positrons to cool down to thermal temperatures so they can diffuse into a very large extended region around the Galactic center. A much more recent star capture may be also able to account for recent TeV observations within 10 pc of the galactic center as well as for the unidentified GeV gamma-ray sources found by EGRET at GC. The spectral difference between the GeV flux and the TeV flux could be explained naturally in this model as well.Comment: Accepted by ApJ on March 24, 200

Bifurcations in annular electroconvection with an imposed shear

We report an experimental study of the primary bifurcation in electrically-driven convection in a freely suspended film. A weakly conducting, submicron thick smectic liquid crystal film was supported by concentric circular electrodes. It electroconvected when a sufficiently large voltage $V$ was applied between its inner and outer edges. The film could sustain rapid flows and yet remain strictly two-dimensional. By rotation of the inner electrode, a circular Couette shear could be independently imposed. The control parameters were a dimensionless number ${\cal R}$, analogous to the Rayleigh number, which is $\propto V^2$ and the Reynolds number ${\cal R}e$ of the azimuthal shear flow. The geometrical and material properties of the film were characterized by the radius ratio $\alpha$, and a Prandtl-like number ${\cal P}$. Using measurements of current-voltage characteristics of a large number of films, we examined the onset of electroconvection over a broad range of $\alpha$, ${\cal P}$ and ${\cal R}e$. We compared this data quantitatively to the results of linear stability theory. This could be done with essentially no adjustable parameters. The current-voltage data above onset were then used to infer the amplitude of electroconvection in the weakly nonlinear regime by fitting them to a steady-state amplitude equation of the Landau form. We show how the primary bifurcation can be tuned between supercritical and subcritical by changing $\alpha$ and ${\cal R}e$.Comment: 17 pages, 12 figures. Submitted to Phys. Rev. E. Minor changes after refereeing. See also http://mobydick.physics.utoronto.c

Novel associations for hypothyroidism include known autoimmune risk loci

Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general population. Here we present the first large genome-wide association study of hypothyroidism, in 2,564 cases and 24,448 controls from the customer base of 23andMe, Inc., a personal genetics company. We identify four genome-wide significant associations, two of which are well known to be involved with a large spectrum of autoimmune diseases: rs6679677 near _PTPN22_ and rs3184504 in _SH2B3_ (p-values 3.5e-13 and 3.0e-11, respectively). We also report associations with rs4915077 near _VAV3_ (p-value 8.3e-11), another gene involved in immune function, and rs965513 near _FOXE1_ (p-value 3.1e-14). Of these, the association with _PTPN22_ confirms a recent small candidate gene study, and _FOXE1_ was previously known to be associated with thyroid-stimulating hormone (TSH) levels. Although _SH2B3_ has been previously linked with a number of autoimmune diseases, this is the first report of its association with thyroid disease. The _VAV3_ association is novel. These results suggest heterogeneity in the genetic etiology of hypothyroidism, implicating genes involved in both autoimmune disorders and thyroid function. Using a genetic risk profile score based on the top association from each of the four genome-wide significant regions in our study, the relative risk between the highest and lowest deciles of genetic risk is 2.1

The challenges of ethical research with children

As especificidades da pesquisa com crianças têm ganhado visibilidade nas produções acadêmicas em diversas áreas de conhecimento, com destaque para a Sociologia da Infância, principalmente a partir dos “novos estudos sobre a infância” os quais emergiram ao final da década de 1980. Essa visibilidade acontece devida a questões como: a discussão sobre as imagens da infância, construídas socio-historicamente; o reconhecimento da condição das crianças enquanto atores sociais, portanto, seres competentes, que atribuem significações a suas experiências e contextos; e o reconhecimento das crianças enquanto sujeitos de direitos, reconhecimento este pautado pela Doutrina da Proteção Integral. Permeadas por essas questões, as pesquisas com crianças agregam a questão da Ética nas atividades desenvolvidas na relação pesquisador-criança. No contexto dessa discussão, este trabalho propõe refletir sobre essas questões e os cuidados éticos nesse tipo de pesquisa, considerando a condição da criança enquanto sujeito de direitos. Foi realizado um recorte da produção acadêmica representativa na área da Sociologia da Infância nas duas últimas décadas, identificando quais aspectos aparecem nas preocupações dos autores, quais abordagens norteiam a discussão desses aspectos e, principalmente, que concepção de infância está presente nessa produção.The specificities of research with children have gained visibility in scientific publications in various areas of knowledge, especially in Sociology of Childhood and the “new studies of childhood”, which emerged at the end of the 1980s. This fact is due to discussions about childhood from a socio-historical perspective; the recognition of children as social actors and therefore able to give meaning to their experiences and contexts; and the recognition of children as individuals entitled to rights, according to the Doutrina da Proteção Integral (Full Protection Doctrine). Therefore, research ethics is an essential element of good research governance, especially in terms of activities related to the relationship between the researcher and child. Accordingly, the objective of this study is to examine and explore these issues, considering the child as an individual entitled to rights. A literature review of articles published in the last two decades in the area of Sociology of Childhood was conducted to identify the main issues and topics addressed, the approaches that guided the discussions and, especially, to identify the conception of childhood present in these studies.CIEC - Centro de Investigação em Estudos da Criança, IE, UMinho (UI 317 da FCT), Portuga

GeneCards Version 3: the human gene integrator

GeneCards (www.genecards.org) is a comprehensive, authoritative compendium of annotative information about human genes, widely used for nearly 15 years. Its gene-centric content is automatically mined and integrated from over 80 digital sources, resulting in a web-based deep-linked card for each of >73 000 human gene entries, encompassing the following categories: protein coding, pseudogene, RNA gene, genetic locus, cluster and uncategorized. We now introduce GeneCards Version 3, featuring a speedy and sophisticated search engine and a revamped, technologically enabling infrastructure, catering to the expanding needs of biomedical researchers. A key focus is on gene-set analyses, which leverage GeneCards’ unique wealth of combinatorial annotations. These include the GeneALaCart batch query facility, which tabulates user-selected annotations for multiple genes and GeneDecks, which identifies similar genes with shared annotations, and finds set-shared annotations by descriptor enrichment analysis. Such set-centric features address a host of applications, including microarray data analysis, cross-database annotation mapping and gene-disorder associations for drug targeting. We highlight the new Version 3 database architecture, its multi-faceted search engine, and its semi-automated quality assurance system. Data enhancements include an expanded visualization of gene expression patterns in normal and cancer tissues, an integrated alternative splicing pattern display, and augmented multi-source SNPs and pathways sections. GeneCards now provides direct links to gene-related research reagents such as antibodies, recombinant proteins, DNA clones and inhibitory RNAs and features gene-related drugs and compounds lists. We also portray the GeneCards Inferred Functionality Score annotation landscape tool for scoring a gene’s functional information status. Finally, we delineate examples of applications and collaborations that have benefited from the GeneCards suite

Identifying and mitigating residual vibrations in wave-based control of lumped, flexible systems

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Wave-based control (WBC) is a technique for motion control of under-actuated flexible sys-tems. It envisages actuator motion as launching a motion wave into the system, while simulta-neously absorbing any wave returning from the system. For rest-to-rest motion the net launch displacement is set at half the target displacement. In absorbing the returning wave and vibra-tions, WBC moves the system the remaining distance to the target, with zero steady-state error. The focus of this paper is on very small residual vibrations around the target position which can endure for a long time after arrival at target. This issue was discovered through a recent devel-opment within WBC context on controlling complex two-dimensional, mass-spring, beam-like arrays. To date their existence has been unidentified. This paper investigates and interprets the nature of these vibrations, explains and identifies them based on wave ideas, and finally offers a new wave-based approach to mitigate or suppress them. It also discusses their implication, not just for WBC but for the general problem of control of flexible systems

Synchrotron Studies of the First-Order Melting Transitions of Hexatic Monolayers and Multilayers in Freely Suspended Liquid-Crystal Films

Synchrotron x-ray diffraction has been used to study the surface and the interior hexatic-to-liquid (smectic-I to smectic-C) melting transitions of freely suspended liquid-crystal films of N-[4'-(n-heptyl)benzylidene]-4-(n-heptyl)aniline (7O.7) five molecular layers thick. Both the surface hexatic monolayers and the interior hexatic layers melt via hysteretic first-order transitions. After the two surface layers undergo a first-order transition to the smectic-I phase, the surface hexatic correlation length $\xi$ evolves smoothly from $\sim 100 to \sim 300 \mathring{A}$ with a roughly square-root form, $\xi \sim \mid T-T_c \mid ^{1/2}$.Engineering and Applied Science