DITHIOCARBAMATE SUBSTITUTED PHENOTHIAZINE DERIVATIVES: IN SILICO EXPERIMENTS, SYNTHESIS, AND BIOLOGICAL EVALUATION

Objective: The present study was designed to study the anticancer activity of a series of novel analogs of phenothiazine with dithiocarbamate as a side chain. Methods: A novel series of derivatives containing dithiocarbamate as a side chain at the tenth position of phenothiazine nucleus were synthesized, characterized by spectral analysis, and evaluated for their antimitotic and antioxidant activity using germinated Bengal gram seeds and 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, respectively. A quantitative estimate of drug-likeness was also performed, which calculated the molecular properties and screened the molecules based on drug-likeness rules. Further, molecular docking study was performed for finding the binding affinity with tubulin protein to rationalize their anticancer activity. Results: The results revealed that the antioxidant activity of compounds 3e, 3g, 3i, 3j and standard Ascorbic acid were 10 mmol, 14 mmol, 16 mmol, 16 mmol and 35 mmol, respectively. Further compounds 3e, 3g, 3h and 3i have shown promising antimitotic activity. Compound 3i (-9 K. Cal/mol) showed the highest binding energies towards tubulin protein when compared to standard drug colchicine (-8.6 K. Cal/mol). Among all, compound 3i showed promising antimitotic and antioxidant activity, which correlated with insilico docking studies. Conclusion: Dithiocarbamate substituted phenothiazine derivatives proved to be encouraging leads as tubulin inhibitors

A System to Filter Unwanted Messages from OSN User Walls

Abstract: The very basic requirement in present days Online Social Networks (OSNs) or Mobile Social Networks (MSNs) is to enable users with the facility to filter and moderate the messages posted on their own private space(like Profile pages, walls etc) to evade that unnecessary content is displayed. As of now Online Social Networks (OSNs) do not provide any kind options in order to fill this user requirement. To address this issue, in this paper, we propose a system allowing Online Social Networks (OSNs) users to have a direct control on the messages posted on their profiles and walls. This is accomplished through a flexible rule-based system, that permits registered users to modify the filtering criteria to be applied to their walls, and Machine Learning based soft classifier automatically labeling messages in support of content-based filtering

Role of Nucleopolyhedroviruses (NPVs)in the Management of Lepidopteran Pests in Asia

The use of synthetic insecticides has been the major approach in modern agriculture for controlling insect pests on different crops in most of the developing countries. Chemical control is one of the effective and quicker methods in reducing pest population, where farmer obtains spectacular results within a short period...

Effect of different storage conditions on the virulence of Helicoverpa armigera nucleopolyhedrovirus (HaNPV).

Studies on the effect of different storage conditions on the virulence of NPV revealed that samples stored in earthen pot and at room temperature maintained efficacy up to four months and after that virulence started decreasing. This decreased efficacy of samples stored under room temperature may be due to increased bacterial activity. When the NPV samples were tested for the bacterial load, it was 3.47 times more in the samples stored at room temperatures after six months of storag

Recovery of Chromium from Ferrochrome Slag

ABSTRACT: Ferrochrome slag generated from alumino-thermi method piles up in large quantities poses many problems to the environment and contaminates ground water on long run, needs to be addressed very urgently. It principally contains chromium, alumina, Iron, magnesium, calcium in small quantities. This paper deals with extraction of chromium and renders the slag harmless. In this paper industrial waste was collected from GTS industries and used in the subsequent experimentation. Ferrochrome slag is treated with lime to conduct slag-lime solid-solid reaction. Chromium present in the slag reacts with lime to form mixed chromates. The reaction is conducted at 973K, soluble chromium ion was extracted with water and is subsequently separated by adsorbing fly ash based zeolite which can be recovered. The recovery of chromium metal in the slag is 64%. The method is viable for the commercial recovery of chromium from slag