Effects of Economic Freedom on Subjective Well-Being

Are people more likely to be satisfied with their lives if they had freedom from regulations, if they had the ability to trade freely internationally? In light of the demographic aging phenomenon we are facing, the present study analyzes the relationship between economic freedom and life satisfaction among European older adults. In order to do so, we are using data from the European Health, Ageing, and Retirement Survey and Economic Freedom of the World. By using the ordered logit regression method, we estimated different models to identify how sub-indicators of economic freedom affect the subjective well-being. According to the findings, the quality of the institutions that define the legal system and establish rules for the protection of private property and sound monetary policy have a positive effect on subjective well-being. On the other hand, openness to international trade has a negative effect and government and regulation doesn’t show any significance.

Optimal Management of Elective Joint Replacement Surgery in Patients with Hemophilia

Hemophilia is a genetic or acquired disease that leads to spontaneous and recurrent bleedings, which affect the joints and muscles, thus determining chronic damage to the cartilage which will lead to joint disease and hemophilic arthropathy. Even though hemophilic patients were initially thought to have a low incidence of atherothrombotic complications, it is now clear that atherothrombotic events occur. The administration of plasmatic factor VIII has better clinical results in type A hemophilic patients than the transfusion with plasma. We analyzed five patients with hemophilia type A, aged between 35 and 62 years. Two of them had a severe form of hemophilia with factor VIII less than 1%, while the other three had a moderate form with factor VIII ranging between 1 and 5%. The five patients underwent total knee repair interventions and received substitution treatment with clotting factors but also prophylactic anticoagulant treatment. The postsurgical evolution of these patients was favorable, with similar hemostatic profile as the non-hemophilic patients. Moroctocog alfa is an efficient substitutive treatment that manages to normalize the hemostatic profile of patients. Therefore, it is recommended to provide prophylactic antithrombotic therapy after the orthopedic interventions

ANALYSIS OF THE STRUCTURAL FUNDS IMPACT ON ECONOMIC DEVELOPMENT IN ROMANIA

The present research objective is to analyze the impact of structural funds available in Romania during 2007 - 2013, especially for economic development of the Romania’s Western Region. The impact analysis will focus on the analysis of evolution of some socio-economic indicators such as absorption rate of structural funds, Gross Domestic Product per capita (GDP), employment rate, unemployment, job vacancies, and the average net salary. The working hypothesis is a high absorption rate of the structural funds can positively influences the economic development of the Romania and especially of the Western Region, which is subject of the case study in this paper

Mineralogical and Geochemical Implications of Weathering Processes Responsible for Soil Generation in Mănăila Alpine Area (Tulgheş 3 Unit—Eastern Carpathians)

In the Mănăila alpine area, the soil layer developed in situ on top of the sericite-schists, which belong to the Tulghes 3 metamorphic unit. The aim of the present work was to determine the degree of soil formation using both mineralogical and geochemical exploration methods. XRD, FTIR and SEM-EDS results showed that the soil constituents were dioctahedral 2:1 minerals, quartz, chlorite, Na-feldspar, rutire and ilmenite. Mainly illite and secondarily mixed-layer minerals were considered to be the most likely minerals resulting from the transformation of sericite and chlorite under acidic alpine conditions. Geochemical modeling inferred the dominance of illite and the presence of smectite as a chlorite alteration product. The weathering indices supported the moderate stage of the soil development agreeing with mineralogical observations. Because of the abundance of sericite and quartz in the parent material, the soil formation was retarded, and its present composition is still related to the bedrocks

Risk of Salinization in the Agricultural Soils of Semi-Arid Regions: A Case Study from Moldavian Plain (NE Romania)

In the present study, the salinization trends of different soil types from a small hydrographic basin situated in NE Romania (Roșior basin) are investigated. The climatic conditions are favorable for long dry summers and intensive evaporation. The soils are developed on immature evolved clay sediments, as revealed by geochemical analysis. The salinity varies among soil types, attaining maximum values for Solonetz with total dissolved salts (TDS) between 1165.75 to 1881.25 mg/L. The aqueous solutions are represented by natural water and soil solution. The hydrogeochemical facies of the natural waters change from HCO3−—Mg2+ in the upper basin to SO42−—Na+ in the middle or lower basin. The soil solution is moderately or strongly salinized and shows anionic variations from HCO3− to SO42− in the studied profiles, whereas Na+ is always the main cation. The concentrations of Na+ and SO42− evolve simultaneously. Raman spectroscopic exploration of the white efflorescences, which occur on topsoil, reveals the presence of thenardite as the dominant phase. The composition of soil solution results from both the ionic exchange and evaporation processes. The nature of soil solution mineralization and summer temperatures are two main factors that interact and promote the thenardite precipitation. The soil salinization induces negative effects on crop nutrition, impacting further the crop yields. The results of this study can be extrapolated to larger areas formed on Sarmatian sedimentary deposits affected by salinization processes

Hereditary Thrombophilia in the Era of COVID-19

Thrombophilia, also called hypercoagulability or prothrombotic condition, usually reflects a certain imbalance that occurs either in the coagulation cascade or in the anticoagulation/fibrinolytic system. A similar imbalance may be induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thrombotic complications are associated with multiorgan failure and increased mortality. In this context, activation of coagulation and thrombocytopenia appeared as prognostic markers in COVID-19. Our work provides a structured and updated analysis of inherited thrombophilia and its involvement in COVID-19, emphasizing the importance of diagnosing and initiating thromboprophylaxis. Since the state of hypercoagulation is directly correlated with COVID-19, we consider that studies on the genetic profiles of proteins involved in thrombophilia in patients who have had COVID-19 and thrombotic events are of great importance, both in treating and in preventing deaths due to COVID-19

Thromboembolic Disease in Haemophilic Patients Undergoing Major Orthopaedic Surgery: Is Thromboprophylaxis Mandatory?

Haemophilia is a rare genetic disorder, that results from various degrees of deficiency of coagulation factor VIII (haemophilia A), or factor IX (haemophilia B), with an X-linked transmission. The patients affected are in the majority of cases males (who inherit the affected X-chromosome from the maternal side), with rare cases of females with haemophilia (FVIII or FIX < 40 IU/dL), situations in which both X-chromosomes are affected, or one is affected, and the other one is inactive (known as carrier). The hypocoagulable state due to the deficiency of clotting factors, manifests as an excessive, recurrent tendency to bleeding, which positively correlates with plasmatic levels. Severe haemophilia results in hemarthrosis, although recent data have shown that moderate or even mild disease can lead to joint bleeding. Recurrent episodes of haemorrhages, usually affecting large joints such as knees, elbows, or ankles, lead to joint remodelling and subsequent haemophilic arthropathy, which may require arthroplasty as a last therapeutic option. Orthopaedic patients have the highest risk among all for deep vein thrombosis (DVT) and venous thromboembolism (VTE) with morbid and potentially fatal consequences. While for the rest of the population thromboprophylaxis in orthopaedic surgery is efficient, relatively safe, and widely used, for patients with haemophilia who are considered to have a low thromboembolic risk, there is great controversy. The great heterogeneity of this particular population, and the lack of clinical trials, with only case reports or observational studies, makes thromboprophylaxis in major orthopaedic surgery a tool to be used by every clinician based on experience and case particularities. This review aims to briefly summarise the latest clinical data and to offer an insight into the current recommendations that readers would find useful in daily practice

The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity

In cancer survivors, cardiac dysfunction is the main cause of mortality. Cardiotoxicity represents a decline in cardiac function associated with cancer therapy, and the risk factors include smoking, dyslipidemia, an age of over 60 years, obesity, and a history of coronary artery disease, diabetes, atrial fibrillation, or heart failure. Troponin is a biomarker that is widely used in the detection of acute coronary syndromes. It has a high specificity, although it is not exclusively associated with myocardial ischemia. The aim of this paper is to summarize published studies and to establish the role of troponin assays in the diagnosis of cardiotoxicity associated with various chemotherapeutic agents. Troponin has been shown to be a significant biomarker in the diagnosis of the cardiac dysfunction associated with several types of chemotherapeutic drugs: anthracyclines, anti-human epidermal growth factor receptor 2 treatment, and anti-vascular endothelial growth factor therapy. Based on the data available at this moment, troponin is useful for baseline risk assessment, the diagnosis of cardiotoxicity, and as a guide for the initiation of cardioprotective treatment. There are currently clear regulations regarding the timing of troponin surveillance depending on the patient&rsquo;s risk of cardiotoxicity and the type of medication administered, but data on the cut-off values of this biomarker are still under investigation

Thromboembolic Disease in Haemophilic Patients Undergoing Major Orthopaedic Surgery: Is Thromboprophylaxis Mandatory?

Haemophilia is a rare genetic disorder, that results from various degrees of deficiency of coagulation factor VIII (haemophilia A), or factor IX (haemophilia B), with an X-linked transmission. The patients affected are in the majority of cases males (who inherit the affected X-chromosome from the maternal side), with rare cases of females with haemophilia (FVIII or FIX &lt; 40 IU/dL), situations in which both X-chromosomes are affected, or one is affected, and the other one is inactive (known as carrier). The hypocoagulable state due to the deficiency of clotting factors, manifests as an excessive, recurrent tendency to bleeding, which positively correlates with plasmatic levels. Severe haemophilia results in hemarthrosis, although recent data have shown that moderate or even mild disease can lead to joint bleeding. Recurrent episodes of haemorrhages, usually affecting large joints such as knees, elbows, or ankles, lead to joint remodelling and subsequent haemophilic arthropathy, which may require arthroplasty as a last therapeutic option. Orthopaedic patients have the highest risk among all for deep vein thrombosis (DVT) and venous thromboembolism (VTE) with morbid and potentially fatal consequences. While for the rest of the population thromboprophylaxis in orthopaedic surgery is efficient, relatively safe, and widely used, for patients with haemophilia who are considered to have a low thromboembolic risk, there is great controversy. The great heterogeneity of this particular population, and the lack of clinical trials, with only case reports or observational studies, makes thromboprophylaxis in major orthopaedic surgery a tool to be used by every clinician based on experience and case particularities. This review aims to briefly summarise the latest clinical data and to offer an insight into the current recommendations that readers would find useful in daily practice