Pooled Analysis of Resistance Patterns of Escherichia coli Strains Isolated From Urine Cultures in Turkey: Comparison of 1997–2001 and 2002–2007 Periods

WOS: 00026328780028

Bibliometric analysis of publications in infectious diseases and clinical microbiology areas: Which coutries led in 1996-2011 and 2011 periods?

WOS: 00020970400051

Nitrofurantoin in the treatment of extended-spectrum ß-lactamase- producing Escherichia coli-related lower urinary tract infection

PubMed ID: 23063743The aim of this study was to evaluate the effect of nitrofurantoin (NFT) in the treatment of extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli-related lower urinary tract infection (LUTI). The hospital records of all patients aged >18 years with dysuria or problems with frequency or urgency in passing urine, >20 leukocytes/mm3 in urine microscopy and culture-proven ESBL-producing NFT-sensitive E. coli in the urine (>105 CFU/mm3), no leukocytosis or fever and who were treated with NFT between January 2006 and May 2011 in our outpatient clinic or in the hospital were evaluated. All patients had received a NFT 50 mg capsule every 6 h for 14 days and had a control urine culture taken 7-9 days after therapy. Clinical success was defined as resolution of symptoms at the control visit, and microbiological success was defined as a sterile control urine culture. A total of 75 patients (mean ± standard deviation age, 54 ± 17 years; 45 females, 30 males, all but 14 with complicated LUTI) fulfilled the study inclusion criteria. Overall clinical and microbiological success rates were 69% (52/75) and 68% (51/75), respectively. Control urine culture performed 28-31 days after the end of therapy was available in 31/51 patients (61%) with microbiological success. Re-infection and relapse rates were 6.5% (2/31) and 3.2% (1/31), respectively. In conclusion, these results suggest that NFT may be an alternative in the treatment of ESBL-producing E. coli-related LUTI. This is the first study in which NFT was used in the treatment of LUTI due to ESBL-producing E. coli as well as in patients with complicated UTI. © 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved

Rifampicin + ceftriaxone versus vancomycin + ceftriaxone in the treatment of penicillin- and cephalosporin-resistant pneumococcal meningitis in an experimental rabbit model

PubMed ID: 16099624This study was planned to compare the efficacy of ceftriaxone + vancomycin with ceftriaxone + rifampicin in a rabbit model of penicillin and cephalosporin-resistant Streptococcus pneumoniae meningitis. Meningitis was induced by intracisternal inoculation of S. pneumoniae. After 18 h of incubation, Group 1 was given saline solution (control group), whilst Groups 2 and 3 were given ceftriaxone + vancomycin and ceftriaxone + rifampicin, respectively. Cerebrospinal fluid bacterial concentrations were measured at 0, 2, 12, 14 and 24 h after therapy was initiated. In the control group, bacterial growth was present at all time points, whereas no growth was observed in either the ceftriaxone + vancomycin group or the ceftriaxone + rifampicin group after 2 h of therapy. Ceftriaxone + rifampicin was found to be as effective as ceftriaxone + vancomycin in the treatment of penicillin-resistant S. pneumoniae meningitis in experimental rabbit model. © 2005 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved

Primary hydatid disease of the occipital bone presenting as space occupying cystic mass of the posterior fossa

Brain involvement of hydatid disease accounts for 1 to 4% of all cases. Extra-Dural, intra-calvarial location is even less. We report, a 24 years old woman with primary intracalvarial hydatid cyst that presented as an extradural cystic mass lesion of the posterior fossa. In the case presented, removal of the pathology without rupture could not be achieved. As same with the other locations, hydatid cysts of calvaria must be tried to be removed without rupture when possible. However, this exceptional host, the calvaria, seems to ease the pre-mature rupture of the cyst due to the neighboring sharp edges of the bone. In such situations, excessive irrigation with hyper-tonic solutions, %3 NaCl for example, is known to be effective for preventing dissemination. Pre-operative diagnosis is very important for surgical planning. Extra-dural locations of cystic lesions must remind the surgeon hydatid cysts especially in the countries where the disease is more common. © 2012 OMU All rights reserved