Antitumour and Immunomodulatory Effects of Cu(II) Complexes of Thiobenzyhdrazide

Thiiobenzyhdrazide (Htbh) and its Cu(II) complexes, [ Cu ( Htbh ) 2 Cl 2 ] and [ Cu ( tbh ) 2 ] were synthesized and characterized by various physicochemical studies. In vivo and in vitro antitumour activity of Htbh, [ Cu ( Htbh ) 2 Cl 2 ] and [ Cu ( tbh ) 2 ] has been tested. LD 50 values were calculated for all the three compounds. It was observed that the antitumour effect of [ Cu ( Htbh ) 2 Cl 2 ] is maximum. Light microscopic study of the treated tumour mass demonstrated that certain cellular degradation, such as disappearance of mitotic figures, loss in cellular compactness, distortion of nucleus and disruption of cytoplasmic boundaries, takes place in the tumour region of complex treated mice. Further, tumour bearing mice administered with Cu(II) complexes showed reversal of tumour growth associated induction of apoptosis in lymphocytes

Antitumor Effect of Some 3d-Metal Complexes of N-Isonicotinoyl-N'-o-Hydroxythiobenzhydrazide

A new ligand, N-isonicotinoyl-N'-o-hydroxythiobenzhydrazide (H2Iotbh), forms complexes [Co(Iotbh)(H2O)2], [M(Iotbh)] [M Ni(II) Cu(II) and Zn(ll)] and [M(Iotbh-H)(H2O)2] [M Mn(III), Fe(III)], which were characterized by various physico-chemical techniques. DMSO solution of metal complexes was observed to inhibit the growth of tumor in vitro, whereas the ligand did not. In vivo administration of these complexes resulted in prolongation of survival of tumor-bearing mice. Tumor-bearing mice administered with the solution of metal complexes showed reversal of tumor growth associated induction of apoptosis in lymphocytes. The paper discusses the possible mechanisms and therapeutic implications of the H2lotbh and its metal complexes in tumor regression and tumor growth associated immunosuppression