Plio-Pleistocene time-averaged field in southern Patagonia recorded in lava flows

Paleomagnetic directions were obtained from stepwise alternating-field or thermal demagnetization of 53 lava flows from southern Patagonia (latitudes 49.5°-52.1 °S) that include the Pali-Aike volcanic field and the Meseta Viscachas plateau lavas. In addition to previous Miocene-late Quaternary ages of these flows, 40Ar/39Ar dates spanning from 0.1 to 15.4 Ma were obtained for 17 of the sites. All except one of the magnetic polarities coincide with the expected polarities of the magnetic polarity timescale [Cande and Kent, 1995] for the obtained 40Ar/39Ar ages. The mean direction from 33 sites (eliminating sites <4 Ma) that pass a selection criteria of α95 ≤5° is Dec = 358.7°,Inc = - 68.2°, α95 = 3.5°, a value that coincides within the statistical uncertainty with the direction of the geocentric axial dipole for that area (Inc = - 68.1°). Likewise, the mean virtual geomagnetic pole (VGP) coincides within the statistical uncertainty with the geographic North Pole. The secular variation described by the VGP angular standard deviation for these sites is 17.1°, a value expected for that latitude according to Model G of paleosecular variation [McFadden et al., 1988]. The characteristics of the data presented are optimum for time-averaged field (TAF) studies because of the good age control and good quality of the paleomagnetic data: (1) primary components of magnetization were obtained using principal component analysis [Kirschvink, 1980] from at least five points and maximum angular deviation ≤5°, (2) site means were calculated with Fisher statistics using at least three samples, and (c) 38 of the 53 flows had α95 ≤ 5°. No results (five sites) or high α95 values (≤5°) were obtained primarily from sites affected by lightning.Fil: Mejia, V.. University of Florida; Estados UnidosFil: Opdyke, N. D.. University of Florida; Estados UnidosFil: Vilas, Juan Francisco A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Geología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Singer, B. S.. University of Wisconsin; Estados UnidosFil: Stoner, J. S.. State University of Colorado at Boulder; Estados Unido

The HPV cellular transactivator Brn-3a can be used to predict cervical adenocarcinoma and squamous carcinoma precancer lesions in the developed and developing worlds

The cellular transactivator Brn-3a has previously been shown to be expressed at elevated levels in the cervix of women with squamous cell carcinoma of the cervix (SCC) and to activate the expression of HPV E6 mRNA. In this study, we show that common and rare cervical precancer lesions, including those of adenocarcinoma (AC), which are usually difficult to diagnose using classical procedures, also expressed high levels of Brn-3a and can be diagnosed by measuring the levels of Brn-3a and E6 mRNAs

Mining Missing Hyperlinks from Human Navigation Traces: A Case Study of Wikipedia

Hyperlinks are an essential feature of the World Wide Web. They are especially important for online encyclopedias such as Wikipedia: an article can often only be understood in the context of related articles, and hyperlinks make it easy to explore this context. But important links are often missing, and several methods have been proposed to alleviate this problem by learning a linking model based on the structure of the existing links. Here we propose a novel approach to identifying missing links in Wikipedia. We build on the fact that the ultimate purpose of Wikipedia links is to aid navigation. Rather than merely suggesting new links that are in tune with the structure of existing links, our method finds missing links that would immediately enhance Wikipedia's navigability. We leverage data sets of navigation paths collected through a Wikipedia-based human-computation game in which users must find a short path from a start to a target article by only clicking links encountered along the way. We harness human navigational traces to identify a set of candidates for missing links and then rank these candidates. Experiments show that our procedure identifies missing links of high quality

A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells.

BackgroundThe recruitment of lymphocytes to secondary lymphoid organs relies on interactions of circulating cells with high endothelial venules (HEV). HEV are exclusive to these organs under physiological conditions, but they can develop in chronically-inflamed tissues. The interaction of L-selectin on lymphocytes with sulfated glycoprotein ligands on HEV results in lymphocyte rolling, which represents the initial step in lymphocyte homing. HEV expression of GlcNAc6ST-2 (also known as HEC-GlcNAc6ST, GST-3, LSST or CHST4), an HEV-restricted sulfotransferase, is essential for the elaboration of L-selectin functional ligands as well as a critical epitope recognized by MECA-79 mAb.ResultsWe examined the expression of GlcNAc6ST-2 in relationship to the MECA-79 epitope in rheumatoid arthritis (RA) synovial vessels. Expression of GlcNAc6ST-2 was specific to RA synovial tissues as compared to osteoarthritis synovial tissues and localized to endothelial cells of HEV-like vessels and small flat-walled vessels. Double MECA-79 and GlcNAc6ST-2 staining showed colocalization of the MECA-79 epitope and GlcNAc6ST-2. We further found that both TNF-alpha and lymphotoxin-alphabeta induced GlcNAc6ST-2 mRNA and protein in cultured human umbilical vein endothelial cells.ConclusionThese observations demonstrate that GlcNAc6ST-2 is induced in RA vessels and provide potential cytokine pathways for its induction. GlcNAc6ST-2 is a novel marker of activated vessels within RA ectopic lymphoid aggregates. This enzyme represents a potential therapeutic target for RA

Gauge-Invariant Coordinates on Gauge-Theory Orbit Space

A gauge-invariant field is found which describes physical configurations, i.e. gauge orbits, of non-Abelian gauge theories. This is accomplished with non-Abelian generalizations of the Poincare'-Hodge formula for one-forms. In a particular sense, the new field is dual to the gauge field. Using this field as a coordinate, the metric and intrinsic curvature are discussed for Yang-Mills orbit space for the (2+1)- and (3+1)-dimensional cases. The sectional, Ricci and scalar curvatures are all formally non-negative. An expression for the new field in terms of the Yang-Mills connection is found in 2+1 dimensions. The measure on Schroedinger wave functionals is found in both 2+1 and 3+1 dimensions; in the former case, it resembles Karabali, Kim and Nair's measure. We briefly discuss the form of the Hamiltonian in terms of the dual field and comment on how this is relevant to the mass gap for both the (2+1)- and (3+1)-dimensional cases.Comment: Typos corrected, more about the non-Abelian decomposition and inner products, more discussion of the mass gap in 3+1 dimensions. Now 23 page