Peer-to-Peer Secure Updates for Heterogeneous Edge Devices

We consider the problem of securely distributing software updates to large scale clusters of heterogeneous edge compute nodes. Such nodes are needed to support the Internet of Things and low-latency edge compute scenarios, but are difficult to manage and update because they exist at the edge of the network behind NATs and firewalls that limit connectivity, or because they are mobile and have intermittent network access. We present a prototype secure update architecture for these devices that uses the combination of peer-to-peer protocols and automated NAT traversal techniques. This demonstrates that edge devices can be managed in an environment subject to partial or intermittent network connectivity, where there is not necessarily direct access from a management node to the devices being updated

Peer to Peer Secure Update for Heterogeneous Edge Devices (Extended Abstract)

No abstract available

Infant speech perception in noise and vocabulary outcomes

This study attempted to investigate the relationship between infant speech perception in noise and vocabulary outcomes. Newman (2005) conducted a series of studies to determine if infants were able to perceive their own name in the context of background noise. It was found that at five months, infants could perceive their own name when the signal-to-noise ratio was at least 10 dB and at thirteen months, infants were able to perceive their own name with a signal-to-noise ratio of at least 5 dB. Children who had participated in this study as infants returned to be assessed in terms of vocabulary and non-verbal intelligence at approximately five years of age. Children were divided into two groups depending on their success as infants and compared on these measures. No significant relationship was found between any of the measures of vocabulary or non-verbal intelligence and initial performance on the speech perception task

Cullin 3–Mediated Regulation of Intracellular Iron Homeostasis Promotes Thymic Invariant NKT Cell Maturation

The E3 ubiquitin ligase cullin 3 (Cul3) is critical for invariant NKT (iNKT) cell development, as iNKT cells lacking Cul3 accumulate in the immature developmental stages. However, the mechanisms by which Cul3 mediates iNKT cell development remain unknown. In this study, we investigated the role of Cul3 in both immature and mature thymic iNKT cells using a mouse model with a T cell–specific deletion of Cul3. We found that mature iNKT cells lacking Cul3 proliferated and died more than wild-type cells did. These cells also displayed increased glucose metabolism and autophagy. Interestingly, we found that tight regulation of iron homeostasis is critical for iNKT cell development. Without Cul3, mature iNKT cells harbored higher levels of cytosolic iron, a phenotype associated with increased cell death. Taken together, our data suggest that Cul3 promotes iNKT cell development partially through intracellular iron homeostasis. ImmunoHorizons, 2023, 7: 235–242

State of Metropolitan America: On the Front Lines of Demographic Transformation

Examines 2000-09 demographic and economic trends and highlights five new realities: growth and outward expansion, population diversification, aging, uneven higher educational attainment, and income polarization. Analyzes national and regional challenges