THERMODYNAMICS OF UNI-UNIVALENT ION EXCHANGE REACTIONS USING STRONGLY ACIDIC CATION EXCHANGE RESIN TULSION T-46

Abstract The study on thermodynamics of ion exchange equilibrium for uni-univalent H + / Na + and H + / K + reaction systems was carried out using strongly acidic cation exchange resin Tulsion T-46. The equilibrium constant K calculated for uni-univalent ion exchange reaction systems were observed to increase with rise in temperature indicating the endothermic ion exchange reactions having the enthalpy values 4.19 and 3.80 kJ /mol respectively

Isolation, characterization and evaluation of anti-proliferative properties of andrographolide isolated from Andrographis paniculata on cultured HaCaT cells

Introduction: Psoriasis is an inflammatory skin disease characterized by hyper-proliferation, abnormal epidermal keratinocytes and inflammatory infiltration. It affects approximately 4% of the population globally. Herbal extracts have better results with less toxic effects than the synthetic drugs in the treatment of psoriasis. Objective: Present study was aimed to access the anti-psoriatic effect of andrographolide extracted from Andrographis paniculate (A. paniculata). Method: We extracted, characterized, and screened the extracted andrographolide for anti-proliferative characteristics using cultured cell model of human HaCaT keratinocyte. Results: Andrographolide at 31.25 µg/mL (90 µM) demonstrated significant inhibitory effect on human HaCaT keratinocytes proliferation in cell culture. To our best knowledge, we reported the anti-proliferative potency of andrographolide extracted from A. paniculata for the first time. Conclusion: The results suggest that the andrographolide extracted from A. paniculata plant may have potential to be used in the management of psoriasis