3 research outputs found
Detection of Porphyromonas gingivalis and Treponema denticola in chronic and aggressive periodontitis patients: A comparative polymerase chain reaction study
The detection frequency of Porphyromonas gingivalis and Treponema denticola in chronic periodontitis (CP) and
aggressive periodontitis (AgP) is not explored well in Indian population. Aim: The study was undertaken to detect P. gingivalis and
T. denticola in CP as well as in AgP patients using polymerase chain reaction (PCR), and to determine the relationship between the
frequency of these two microorganisms and the severity of clinical periodontal parameters. Materials and Methods: Subgingival
plaque samples were collected from ninety participants (thirty CP patients, thirty AgP patients, and thirty healthy participants) and
the aforementioned two microorganisms were detected using PCR. Results: However, when CP and AgP were compared for
the detection frequency of two microorganisms, no statistically significant difference was noted. A statistically significant increase
in the number of bacteria‑positive sites increased as the score of plaque index (PI), gingival index (GI), and clinical attachment
level of CP and AgP patients increased. Coexistence of P. gingivalis and T. denticola was frequently observed in deep periodontal
pockets. Conclusions: Study findings suggest that P. gingivalis and T. denticola are significantly associated with the severity of
periodontal tissue destruction. Statistically significant association exists between clinical periodontal parameters such as PI, GI,
periodontal pocket depth (PPD), and clinical attachment loss and presence of both the microorganism
Apoptosis: Molecular mechanism
Cell death is one of the essential processes. Balance between cell division and cell death is of utmost importance for the development and maintenance of multi-cellular organism. Disorders of either process have pathologic consequences and can lead to disturbed embryogenesis, neurodegerative diseases, or the development of cancers. This article reviews the apoptotic as well as anti-apoptotic molecules along with molecular pathways, which may alter in many diseases