13 research outputs found
Fertility preservation in females with malignant disease-1: causes, clinical needs and indications
Cancer incidence is progressively increasing in parallel with an increase in the rate of cancer survivors with the help of advanced treatment modalities. By the year 2010, it is estimated that one in every 250 persons will have survived a childhood malignancy. The increased rates of survival bring about complications related to reproductive health. Cytotoxic treatments due to chemo- and radiotherapy or bone marrow transplantation suppress or irreversibly harm not only female ovarian reserve but also male testicular sperm production. In this review, cryopreservation of gametes and gonads with fertility preservation options and indications prior to cancer treatments are discussed
Kronik miyeloid lösemi tedavi dozunda Nilotinib’in gonadotoksik etkilerinin fare modelinde gösterilmesi
Objective: Tyrosine kinase inhibitors may have deleterious effects
on spermatogenesis or folliculogenesis, resulting in male or female
subfertility. The aim of this study is to determine the effect of
nilotinib, which is used routinely to treat chronic myeloid leukemia,
on spermatogenesis and folliculogenesis by using histopathological
parameters.
Materials and Methods: Ten male and ten female mice were orally
treated with nilotinib at 20 mg/kg body weight dissolved in drinking
water daily for 2 months.
Results: When compared with the control group, a statistically
significant decrease was demonstrated in the total follicle numbers of
the female mice in the nilotinib group (268±110 vs. 170±60; p=0.03).
Active spermatogenesis was observed in each tubule sample taken
from the mice in the control and nilotinib groups. Spermatogenic
activity was similar in the two groups.
Conclusion: We have demonstrated that even though spermatogenesis
is preserved, folliculogenesis is inhibited by the usage of a continuous
nilotinib treatment dose in chronic myeloid leukemia
Gonadotoxic effects of nilotinib in chronic myeloid leukemia treatment dose in a mouse model
Objective: Tyrosine kinase inhibitors may have deleterious effects on spermatogenesis or folliculogenesis, resulting in male or female subfertility. The aim of this study is to determine the effect of nilotinib, which is used routinely to treat chronic myeloid leukemia, on spermatogenesis and folliculogenesis by using histopathological parameters.
Materials and Methods: Ten male and ten female mice were orally treated with nilotinib at 20 mg/kg body weight dissolved in drinking water daily for 2 months
Results: When compared with the control group, a statistically significant decrease was demonstrated in the total follicle numbers of the female mice in the nilotinib group (268±110 vs. 170±60; p=0.03). Active spermatogenesis was observed in each tubule sample taken from the mice in the control and nilotinib groups. Spermatogenic activity was similar in the two groups.
Conclusion: We have demonstrated that even though spermatogenesis is preserved, folliculogenesis is inhibited by the usage of a continuous nilotinib treatment dose in chronic myeloid leukemia
The effect of nilotinib in chronic myeloid leukemia treatment dose on fertility and teratogenicity in a healthy
20th Congress of European-Hematology-Association -- JUN 11-14, 2015 -- Vienna, AUSTRI