Chiral rings and GSO projection in Orbifolds

The GSO projection in the twisted sector of orbifold background is sometimes subtle and incompatible descriptions are found in literatures. Here, from the equivalence of partition functions in NSR and GS formalisms, we give a simple rule of GSO projection for the chiral rings of string theory in \C^r/\Z_n, $r=1,2,3$. Necessary constructions of chiral rings are given by explicit mode analysis.Comment: 24 page

Some empirical evidences on ASEAN 5 fiscal policy regime and monetary and fiscal policy interactions

The interest of common currency among Asian countries have spurred many events happening for the past few years, notably the declaration of Asian Currency Unit in 2006 by Asia Development Bank (ADB). Hence, research papers examining on the integration of monetary policies are abundance. However, paper on examining fiscal policy regime and interaction between monetary and fiscal policy on ASEAN countries, is lacking. The success of monetary union relies on the price stability of member nations. However, joining a monetary union means the lost of monetary policy sovereignty. Therefore, fiscal policy turns to be the next important tool to maintain price stability. This is reflected from the EMU countries after year 1999, where national monetary policies are completely centralized to the European Central Bank (ECB). The European System of Central Banks (ESCB) combines unity of decisions with participation of national central banks in the decision making process and implementation. Nevertheless, national fiscal policies of the member countries are still in the hands of the national governments. This paper intents to examine the type of fiscal policy regime practiced by ASEAN 5 countries. Using macro-economic data for Indonesia, Malaysia, Philippines, Singapore and Thailand, the interrelationship of government surplus/deficits and liabilities is analyzed using Correlation test, Vector Auto-regression (VAR) and Impulse response (IR) function to determine whether a Ricardian or Non-Ricardian fiscal policy has been implemented. Also, comparison of monetary and fiscal policy interactions between some EMU countries and ASEAN 5 are made. The results indicate interactions among inter EMU countries and inter ASEAN countries are generally comparable

MmpL3 is the flippase for mycolic acids in mycobacteria

The defining feature of the mycobacterial outer membrane (OM) is the presence of mycolic acids (MAs), which, in part, render the bilayer extremely hydrophobic and impermeable to external insults, including many antibiotics. Although the biosynthetic pathway of MAs is well studied, the mechanism(s) by which these lipids are transported across the cell envelope is(are) much less known. Mycobacterial membrane protein Large 3 (MmpL3), an essential inner membrane (IM) protein, is implicated in MA transport, but its exact function has not been elucidated. It is believed to be the cellular target of several antimycobacterial compounds; however, evidence for direct inhibition of MmpL3 activity is also lacking. Here, we establish that MmpL3 is the MA flippase at the IM of mycobacteria and is the molecular target of BM212, a 1,5-diarylpyrrole compound. We develop assays that selectively access mycolates on the surface of Mycobacterium smegmatis spheroplasts, allowing us to monitor flipping of MAs across the IM. Using these assays, we establish the mechanism of action of BM212 as a potent MmpL3 inhibitor, and use it as a molecular probe to demonstrate the requirement for functional MmpL3 in the transport of MAs across the IM. Finally,we showthat BM212 bindsMmpL3 directly and inhibits its activity. Our work provides fundamental insights into OM biogenesis and MA transport in mycobacteria. Furthermore, our assays serve as an important platform for accelerating the validation of small molecules that target MmpL3, and their development as future antituberculosis drugs

Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Caenorhabditis elegans Lysates

Protein aggregation is a hallmark of several neurodegenerative diseases and is associated with impaired protein homeostasis. This imbalance is caused by the loss of the protein's native conformation, which ultimately results in its aggregation or abnormal localization within the cell. Using a C. elegans model of polyglutamine diseases, we describe in detail the filter retardation assay, a method that captures protein aggregates in a cellulose acetate membrane and allows its detection and quantification by immunoblotting

Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans

C. elegans is widely used to investigate biological processes related to health and disease. To study protein localization, fluorescently-tagged proteins can be used in vivo or immunohistochemistry can be performed in whole worms. Here, we describe a technique to localize a protein of interest at a subcellular level in C. elegans lysates, which can give insight into the location, function and/or toxicity of proteinsNational Institutes of Health National Centre for Research Resources (NIH)European Research Council (ERC)USANIH National Center for Research Resources (NCRR)Japan National BioResource Projec

Connecting with family, friends and others: informal caregiving among international postgraduate researchers in a British University

\ua9 2024, STAR Scholars Network. All rights reserved.This article casts light on informal caregiving, an essential aspect of the international postgraduate researcher (PGR) experience, but which is often invisible in literature and discourses on international education. Drawing from qualitative semi-structured interviews with international PGRs in a British university, it highlights their dual role as care recipients and lesser known caregivers across transnational and local spaces. It gives insights into the forms and dynamics of care that they give to and receive from family, friends and others, uncovering the emotional and affective aspects of undertaking a postgraduate research degree overseas which impact on their mental wellbeing. The findings have implications for the improvement of university support for international PGRs which has relevance for the wider international student community