Space Radiation Program Element Tissue Sharing Initiative

No abstract availabl

Space Radiation Program Element Tissue Sharing Initiative

Over the years, a large number of animal experiments have been conducted at the NASA Space Radiation Laboratory and other facilities under the support of the NASA Space Radiation Program Element (SRPE). Studies using rodents and other animal species to address the space radiation risks will remain a significant portion of the research portfolio of the Element. In order to maximize scientific return of the animal studies, SRPE is taking the initiative to promote tissue sharing among the scientists in the space radiation research community. This initiative is enthusiastically supported by the community members as voiced in the responses to a recent survey. For retrospective tissue samples, an online platform will be established for the PIs to post a list of the available samples, and to exchange information with the potential recipients. For future animal experiments, a tissue sharing policy is being developed by SRPE

Contextual compositionality detection with external knowledge bases and word embeddings

When the meaning of a phrase cannot be inferred from the individual meanings of its words (e.g., hot dog), that phrase is said to be non-compositional. Automatic compositionality detection in multiword phrases is critical in any application of semantic processing, such as search engines [9]; failing to detect non-compositional phrases can hurt system effectiveness notably. Existing research treats phrases as either compositional or non-compositional in a deterministic manner. In this paper, we operationalize the viewpoint that compositionality is contextual rather than deterministic, i.e., that whether a phrase is compositional or non-compositional depends on its context. For example, the phrase \ufffdgreen card\ufffd is compositional when referring to a green colored card, whereas it is non-compositional when meaning permanent residence authorization. We address the challenge of detecting this type of contextual compositionality as follows: given a multi-word phrase, we enrich the word embedding representing its semantics with evidence about its global context (terms it often collocates with) as well as its local context (narratives where that phrase is used, which we call usage scenarios). We further extend this representation with information extracted from external knowledge bases. The resulting representation incorporates both localized context and more general usage of the phrase and allows to detect its compositionality in a non-deterministic and contextual way. Empirical evaluation of our model on a dataset of phrase compositionality1, manually collected by crowdsourcing contextual compositionality assessments, shows that our model outperforms state-of-the-art baselines notably on detecting phrase compositionality

An Overview of NASA's Risk of Cardiovascular Disease from Radiation Exposure

The association between high doses of radiation exposure and cardiovascular damage is well established. Patients that have undergone radiotherapy for primary cancers of the head and neck and mediastinal regions have shown increased risk of heart and vascular damage and long-term development of radiation-induced heart disease [1]. In addition, recent meta-analyses of epidemiological data from atomic bomb survivors and nuclear industry workers has also shown that acute and chronic radiation exposures is strongly correlated with an increased risk of circulatory disease at doses above 0.5 Sv [2]. However, these analyses are confounded for lower doses by lifestyle factors, such as drinking, smoking, and obesity. The types of radiation found in the space environment are significantly more damaging than those found on Earth and include galactic cosmic radiation (GCR), solar particle events (SPEs), and trapped protons and electrons. In addition to the low-LET data, only a few studies have examined the effects of heavy ion radiation on atherosclerosis, and at lower, space-relevant doses, the association between exposure and cardiovascular pathology is more varied and unclear. Understanding the qualitative differences in biological responses produced by GCR compared to Earth-based radiation is a major focus of space radiation research and is imperative for accurate risk assessment for long duration space missions. Other knowledge gaps for the risk of radiation-induced cardiovascular disease include the existence of a dose threshold, low dose rate effects, and potential synergies with other spaceflight stressors. The Space Radiation Program Element within NASA's Human Research Program (HRP) is managing the research and risk mitigation strategies for these knowledge gaps. In this presentation, we will review the evidence and present an overview of the HRP Risk of Cardiovascular Disease and Other Degenerative Tissue Effects from Radiation Exposure

Space Radiation and Risks to Human Health

The radiation environment in space poses significant challenges to human health and is a major concern for long duration manned space missions. Outside the Earth's protective magnetosphere, astronauts are exposed to higher levels of galactic cosmic rays, whose physical characteristics are distinct from terrestrial sources of radiation such as xrays and gammarays. Galactic cosmic rays consist of high energy and high mass nuclei as well as high energy protons; they impart unique biological damage as they traverse through tissue with impacts on human health that are largely unknown. The major health issues of concern are the risks of radiation carcinogenesis, acute and late decrements to the central nervous system, degenerative tissue effects such as cardiovascular disease, as well as possible acute radiation syndromes due to an unshielded exposure to a large solar particle event. The NASA Human Research Program's Space Radiation Program Element is focused on characterization and mitigation of these space radiation health risks along with understanding these risks in context of the other biological stressors found in the space environment. In this overview, we will provide a description of these health risks and the Element's research strategies to understand and mitigate these risks

Overview of Space Radiation Health Risks with a Focus on Radiation Induced Cardiovascular Diseases

No abstract availabl

Concepts for manned lunar habitats

The design philosophy that will guide the design of early lunar habitats will be based on a compromise between the desired capabilities of the base and the economics of its development and implantation. Preferred design will be simple, make use of existing technologies, require the least amount of lunar surface preparation, and minimize crew activity. Three concepts for an initial habitat supporting a crew of four for 28 to 30 days are proposed. Two of these are based on using Space Station Freedom structural elements modified for use in a lunar-gravity environment. A third concept is proposed that is based on an earlier technology based on expandable modules. The expandable modules offer significant advantages in launch mass and packaged volume reductions. It appears feasible to design a transport spacecraft lander that, once landed, can serve as a habitat and a stand-off for supporting a regolith environmental shield. A permanent lunar base habitat supporting a crew of twelve for an indefinite period can be evolved by using multiple initial habitats. There appears to be no compelling need for an entirely different structure of larger volume and increased complexity of implantation

Radiation Analysis for the Human Lunar Return Mission

An analysis of the radiation hazards that are anticipated on an early Human Lunar Return (HLR) mission in support of NASA deep space exploration activities is presented. The HLR mission study emphasized a low cost lunar return to expand human capabilities in exploration, to answer fundamental science questions, and to seek opportunities for commercial development. As such, the radiation issues are cost related because the parasitic shield mass is expensive due to high launch costs. The present analysis examines the shield requirements and their impact on shield design