Architect Jan Sterenberg en het wonen in de jaren ’70: Groeikernen en woonmilieus

Book review of a book written by Michiel KruidenierBespreking van een boek van Michiel Kruidenie

Het Stegengebied in beweging

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Het Stegengebied in beweging

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Long-Term Stroke Risk in Patients With New Ischemic Brain Lesions on MRI After Carotid Revascularization

BACKGROUND: Carotid artery revascularization can result in new ischemic brain lesions on diffusion-weighted magnetic resonance imaging. This study aimed to investigate the relationship between periprocedural ischemic diffusion-weighted imaging (DWI) lesions after carotid artery revascularization and recurrent long-term cerebrovascular events. METHODS: A secondary observational prospective cohort analysis of existing clinical trial data was performed on 162 patients with symptomatic carotid stenosis that were previously randomized to carotid artery stenting or carotid endarterectomy in the ICSS (International Carotid Stenting Study) and included in the magnetic resonance imaging substudy. Magnetic resonance imagings were performed 1 to 7 days before and 1 to 3 days after treatment. The primary composite clinical outcome was the time to any stroke or transient ischemic attack during follow-up. Patients with new diffusion-weighted imaging (DWI) lesions on posttreatment magnetic resonance imaging scan (DWI+) were compared with patients without new lesions (DWI-). RESULTS: The median time of follow-up was 8.6 years (interquartile range, 5.0-12.5). Kaplan-Meier cumulative incidence for the primary outcome after 12.5-year follow-up was 35.3% (SE, 8.9%) in DWI+ patients and 31.1% (SE, 5.6%) in DWI- patients. Uni- and multivariable regression analyses did not show significant differences (hazard ratio, 1.50 [95% CI, 0.76-2.94] and hazard ratio, 1.30 [95% CI, 0.10-1.02], respectively). Higher event rate of the primary outcome in DWI+ patients in the overall cohort was mainly caused by events in the carotid artery stenting group. CONCLUSIONS: Based on our outcome analysis within the ICSS magnetic resonance imaging substudy, DWI lesions following carotid revascularization did not seem to have a relationship with long-term stroke risk. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: ISRCTN 25337470.</p

Long-Term Stroke Risk in Patients With New Ischemic Brain Lesions on MRI After Carotid Revascularization

BACKGROUND: Carotid artery revascularization can result in new ischemic brain lesions on diffusion-weighted magnetic resonance imaging. This study aimed to investigate the relationship between periprocedural ischemic diffusion-weighted imaging (DWI) lesions after carotid artery revascularization and recurrent long-term cerebrovascular events. METHODS: A secondary observational prospective cohort analysis of existing clinical trial data was performed on 162 patients with symptomatic carotid stenosis that were previously randomized to carotid artery stenting or carotid endarterectomy in the ICSS (International Carotid Stenting Study) and included in the magnetic resonance imaging substudy. Magnetic resonance imagings were performed 1 to 7 days before and 1 to 3 days after treatment. The primary composite clinical outcome was the time to any stroke or transient ischemic attack during follow-up. Patients with new diffusion-weighted imaging (DWI) lesions on posttreatment magnetic resonance imaging scan (DWI+) were compared with patients without new lesions (DWI-). RESULTS: The median time of follow-up was 8.6 years (interquartile range, 5.0-12.5). Kaplan-Meier cumulative incidence for the primary outcome after 12.5-year follow-up was 35.3% (SE, 8.9%) in DWI+ patients and 31.1% (SE, 5.6%) in DWI- patients. Uni- and multivariable regression analyses did not show significant differences (hazard ratio, 1.50 [95% CI, 0.76-2.94] and hazard ratio, 1.30 [95% CI, 0.10-1.02], respectively). Higher event rate of the primary outcome in DWI+ patients in the overall cohort was mainly caused by events in the carotid artery stenting group. CONCLUSIONS: Based on our outcome analysis within the ICSS magnetic resonance imaging substudy, DWI lesions following carotid revascularization did not seem to have a relationship with long-term stroke risk. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: ISRCTN 25337470

The cohesive band model: A cohesive surface formulation with stress triaxiality

In the cohesive surface model cohesive tractions are transmitted across a two-dimensional surface, which is embedded in a three-dimensional continuum. The relevant kinematic quantities are the local crack opening displacement and the crack sliding displacement, but there is no kinematic quantity that represents the stretching of the fracture plane. As a consequence, in-plane stresses are absent, and fracture phenomena as splitting cracks in concrete and masonry, or crazing in polymers, which are governed by stress triaxiality, cannot be represented properly. In this paper we extend the cohesive surface model to include in-plane kinematic quantities. Since the full strain tensor is now available, a three-dimensional stress state can be computed in a straightforward manner. The cohesive band model is regarded as a subgrid scale fracture model, which has a small, yet finite thickness at the subgrid scale, but can be considered as having a zero thickness in the discretisation method that is used at the macroscopic scale. The standard cohesive surface formulation is obtained when the cohesive band width goes to zero. In principle, any discretisation method that can capture a discontinuity can be used, but partition-of-unity based finite element methods and isogeometric finite element analysis seem to have an advantage since they can naturally incorporate the continuum mechanics. When using interface finite elements, traction oscillations that can occur prior to the opening of a cohesive crack, persist for the cohesive band model. Example calculations show that Poisson contraction influences the results, since there is a coupling between the crack opening and the in-plane normal strain in the cohesive band. This coupling holds promise for capturing a variety of fracture phenomena, such as delamination buckling and splitting cracks, that are difficult, if not impossible, to describe within a conventional cohesive surface model. © 2013 Springer Science+Business Media Dordrecht

Het Stegengebied in beweging

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