Multidimensional perfectionism and narcissism: Grandiose or vulnerable?

Multidimensional perfectionism is related to grandiose narcissism, with other-oriented perfectionism showing the strongest, most consistent relationships. The relationships with vulnerable narcissism, however, are unclear. Our study investigated how three forms of perfectionism--self-oriented, other-oriented, and socially prescribed perfectionism (Hewitt & Flett, 1991)--are related to narcissistic grandiosity and vulnerability. A sample of 375 university students completed the Narcissistic Personality Inventory (Raskin & Terry, 1988), Hypersensitive Narcissism Scale (Hendin & Cheek, 1997), and Pathological Narcissism Inventory (Pincus et al., 2009) capturing various facets of narcissistic grandiosity and vulnerability. Multiple regressions were conducted controlling for the overlap between the three forms of perfectionism and gender. Other-oriented perfectionism showed unique positive relationships with key facets of grandiose narcissism. In contrast, socially prescribed perfectionism showed positive relationships with all facets of vulnerable narcissism. Self- and other-oriented perfectionism showed positive relationships with individual facets only. Other-oriented perfectionism appears to represent a form of perfectionism predominantly related to narcissistic grandiosity, whereas socially prescribed perfectionism is predominantly related to narcissistic vulnerability. As the first study to examine perfectionism in relation to narcissistic grandiosity and vulnerability, our research both extends and clarifies the nomological network of the perfectionism construct in important ways

Doctor of Philosophy

dissertationAppropriate regulation of gene expression is important for the development and homeostasis of multicellular organisms. DNA sequencespecific transcription factors play a central role in regulating the first step of gene expression, transcription. The aberrant expression of transcription factors is a common mechanism for the initiation and progression of many human cancers. The ETS family of transcription factors consists of twenty-eight human proteins that contain a conserved DNA-binding domain, termed the ETS domain. ETS factors have varied roles in organismal development and disease etiology. For example, ETS proteins from the ERG and ETV1/4/5 subfamilies are overexpressed in the majority of prostate cancers and contribute to cancer initiation and progression. In stark contrast, EHF and SPDEF are two ETS factors present in normal prostate tissue that have been characterized as tumor suppressors whose genes are often deleted during cancer progression. The phenotypic dichotomy displayed between these subclasses of ETS factors suggests that the understanding of the molecular mechanisms that underlie transcription factors' roles in normal and disease settings may provide additional opportunities for therapeutic intervention. Here we describe the DNA-binding autoinhibition of ETS factors ETV1, iv ETV4, and ETV5. An intrinsically disordered region and an α-helix cooperate to inhibit DNA-binding by altering the positioning of the DNA-recognition α-helix of the ETS domain. These inhibitory elements are distinct from those that have been previously described for other ETS factors. We also characterize the interaction of Mediator subunit 25 (MED25) with the transcriptional activation and DNA-binding domains of ETV4. The inhibitory α-helix of ETV4 provides a unique interaction surface for MED25, as compared to other ETS domains, and interaction with MED25 activates the DNA-binding of ETV4. We also demonstrate the differential ability of ETS factors to bind to DNA with JUN-FOS at composite DNA binding sites. These distinct intra- and intermolecular interactions distinguish ETS oncoproteins and tumor suppressors in prostate cancer and may, in part, underlie their phenotypic differences. Finally, we present an assay for ETS-DNA interactions that is amenable to high-throughput screening for small molecule inhibitors. This assay could be further modified to incorporate any of the previously described partnerships

PROVE Endurance Car Front Suspension

This document details the collaborative Mechanical Engineering Senior Project with Cal Poly PROVE Lab on PROVE Lab’s Project 2; an electric vehicle designed to travel 1000 miles on a single charge. Logan Simon, Justine Kwan, and Lauren Williams are given the challenge of designing an innovative proof of concept front suspension suspension for this vehicle. After detailed research of new suspension systems, it was determined that the innovative nature could be in the form of unique manufacturing methods, materials use, or mechanical design. At this point in time, this vehicle is a purely conceptual design with no concrete requirements. Therefore engineering specifications were generated based on vehicles of similar size and function, such as PROVE Lab Project 1, Tesla’s Roadster, and the BMW z4. These specification included vehicle weight, speed, vertical travel, system weight, travel speed, and track width. Since this car is aimed to travel 1000 miles on one charge, efficiency is a big concern for the design. From ideation, the three suspension configurations of interest were MacPherson, double wishbone, and multi-link. A decision matrix was created to evaluate these designs based on design requirements, resulting in the selection of the multi-link configuration. However, after further investigation it was decided that a double wishbone configuration would provide nearly equal performance and be much more manageable of a task on the senior project time frame, compared to multi-link. The focus of the project then shifted to innovative manufacturing methods. Carbon fiber was chosen as the material to be used due to its lightweight nature, its accessibility through PROVE lab, and its lack of usage in a suspension system thus far. The upright would provide the most weight savings, so it was designed as a carbon fiber sandwich panel. Computer analysis of the system included SolidWorks FEA, Tsai Wu Failure Analysis, and ANSYS composite analysis to verify Tsai Wu. Four destructive tests were performed to validate the analysis and to determine the number of plies to be used for the final part. With all four tests passing the minimum load requirements with a factor of safety above 1, 16 plies per laminate was chosen and with an additional 8 plies around the edges. The final system proves that a carbon fiber suspension that is structurally sound for maximum loading cases and that cuts weight down to 4.3 pounds is possible. The full non-destructive test will be performed by the PROVE Project 2 team in the future, unassociated with this senior project

Corporate Governance In The Lodging Industry: Special Case Of The Service Industry

This paper examines the corporate governance structure of publicly traded hospitality firms and determines whether the governance structure selected by these firms is consistent with minimizing monitoring and bonding costs dictated by the complexity of the business models. There is strong evidence that complex firms had larger board of directors, more outside board members, a greater fraction of CEO pay being variable, and more frequent occurrence of CEO/Chairman duality than simple firms. The results also present evidence of a positive relationship between firms that have the appropriate governance structures and the profitability and valuation of the firm

Demographics and the Marketing of Asian Ethnic Produce in the Mid-Atlantic States

Marketing,

Association between Physical and Motor Fitness with Cognition in Children

Background and objective: There is an increased interest in exploring the association between fitness components with cognitive development in children in recent years. One of the scopes is to find the best exercise prescription to enhance health and cognition. Most of the studies so far have focused on cardiorespiratory fitness with little evidence on other fitness components. The present study aimed to explore the association between physical fitness (PF) and motor fitness (MF) with cognitive performance in children. Methods: Two hundred and six schoolboys (11.0 ± 0.8 y) underwent a battery of tests to measure information processing speed (i.e., simple and choice reaction time) and inhibitory control (i.e., Simon task). PF components (i.e., flexibility, muscular strength, and endurance) and MF components (speed and agility) were measured. Results: Multiple linear regression analysis adjusted for potential confounders (i.e., age, socioeconomic status, %fat and physical activity) revealed no relationship between flexibility, speed, muscular strength, and endurance with either information processing tasks or inhibitory control tasks. However, a positive association was observed between agility with both congruent reaction time and incongruent reaction time. Conclusions: No relationship was observed between the underlying fitness components with either information processing or inhibitory control. However, an association was observed between agility with inhibitory control

Cortical Surface Diffusion Generative Models

Cortical surface analysis has gained increased prominence, given its potential implications for neurological and developmental disorders. Traditional vision diffusion models, while effective in generating natural images, present limitations in capturing intricate development patterns in neuroimaging due to limited datasets. This is particularly true for generating cortical surfaces where individual variability in cortical morphology is high, leading to an urgent need for better methods to model brain development and diverse variability inherent across different individuals. In this work, we proposed a novel diffusion model for the generation of cortical surface metrics, using modified surface vision transformers as the principal architecture. We validate our method in the developing Human Connectome Project (dHCP), the results suggest our model demonstrates superior performance in capturing the intricate details of evolving cortical surfaces. Furthermore, our model can generate high-quality realistic samples of cortical surfaces conditioned on postmenstrual age(PMA) at scan.Comment: 4 page

Asymptotics of Plancherel-type random partitions

We present a solution to a problem suggested by Philippe Biane: We prove that a certain Plancherel-type probability distribution on partitions converges, as partitions get large, to a new determinantal random point process on the set {0,1,2,...} of nonnegative integers. This can be viewed as an edge limit ransition. The limit process is determined by a correlation kernel on {0,1,2,...} which is expressed through the Hermite polynomials, we call it the discrete Hermite kernel. The proof is based on a simple argument which derives convergence of correlation kernels from convergence of unbounded self-adjoint difference operators. Our approach can also be applied to a number of other probabilistic models. As an example, we discuss a bulk limit for one more Plancherel-type model of random partitions.Comment: AMS TeX, 19 pages. Version 2: minor typos fixe