Quantum nondemolition measurement of a nonclassical state of a massive object

While quantum mechanics exquisitely describes the behavior of microscopic systems, one ongoing challenge is to explore its applicability to systems of larger size and mass. Unfortunately, quantum states of increasingly macroscopic objects are more easily corrupted by unintentional measurements from the classical environment. Additionally, even the intentional measurements from the observer can further perturb the system. In optomechanics, coherent light fields serve as the intermediary between the fragile mechanical states and our inherently classical world by exerting radiation pressure forces and extracting mechanical information. Here we engineer a microwave cavity optomechanical system to stabilize a nonclassical steady-state of motion while independently, continuously, and nondestructively monitoring it. By coupling the motion of an aluminum membrane to two microwave cavities, we separately prepare and measure a squeezed state of motion. We demonstrate a quantum nondemolition (QND) measurement of sub-vacuum mechanical quadrature fluctuations. The techniques developed here have direct applications in the areas of quantum-enhanced sensing and quantum information processing, and could be further extended to more complex quantum states.Comment: 9 pages, 6 figure

Demonstration of efficient nonreciprocity in a microwave optomechanical circuit

The ability to engineer nonreciprocal interactions is an essential tool in modern communication technology as well as a powerful resource for building quantum networks. Aside from large reverse isolation, a nonreciprocal device suitable for applications must also have high efficiency (low insertion loss) and low output noise. Recent theoretical and experimental studies have shown that nonreciprocal behavior can be achieved in optomechanical systems, but performance in these last two attributes has been limited. Here we demonstrate an efficient, frequency-converting microwave isolator based on the optomechanical interactions between electromagnetic fields and a mechanically compliant vacuum gap capacitor. We achieve simultaneous reverse isolation of more than 20 dB and insertion loss less than 1.5 dB over a bandwidth of 5 kHz. We characterize the nonreciprocal noise performance of the device, observing that the residual thermal noise from the mechanical environments is routed solely to the input of the isolator. Our measurements show quantitative agreement with a general coupled-mode theory. Unlike conventional isolators and circulators, these compact nonreciprocal devices do not require a static magnetic field, and they allow for dynamic control of the direction of isolation. With these advantages, similar devices could enable programmable, high-efficiency connections between disparate nodes of quantum networks, even efficiently bridging the microwave and optical domains.Comment: 9 pages, 6 figure

Outbreak of acute hepatitis C following the use of anti-hepatitis C virus--screened intravenous immunoglobulin therapy

BACKGROUND and AIMS: Hepatitis C virus (HCV) infection has been associated with intravenous (IV) immunoglobulin (Ig), and plasma donations used to prepare IV Ig are now screened to prevent transmission. Thirty-six patients from the United Kingdom received infusions from a batch of anti-HCV antibody-screened intravenous Ig (Gammagard; Baxter Healthcare Ltd., Thetford, Norfolk, England) that was associated with reports of acute hepatitis C outbreak in Europe. The aim of this study was to document the epidemiology of this outbreak. METHODS: Forty-six patients from the United Kingdom treated with Gammagard (34 exposed and 12 unexposed to the batch) returned epidemiological questionnaires. RESULTS: Eighty-two percent of the exposed patients (28 of 34) became positive for HCV RNA. Eighteen percent of the patients (6 of 34) who had infusions with this batch tested negative for HCV RNA, but 2 of the patients had abnormal liver function and subsequently seroconverted to anti-HCV antibody positive. Twenty-seven percent of the patients (9 of 34) developed jaundice, and 79% (27 of 34) had abnormal liver transferase levels. Virus isolates (n=21), including an isolate from the implicated batch, were genotype 1a and virtually identical by sequence analysis of the NS5 region, consistent with transmission from a single source. CONCLUSIONS: Hepatitis C infection can be transmitted by anti-HCV-screened IV Ig. Careful documentation of IV Ig batch numbers and regular biochemical monitoring is recommended for all IV Ig recipients