Structure-activity relationship studies on new DABOS: effect of substitutions at pyrimidine C-5 and C-6 positions on anti-HIV-1 activity.

Several 5-alkyl, 5-alkenyl, 5-iso-alkyl, 5-halo, 5-aminomethyl and 5-carboxy derivatives of S-DABOs (dihydro-alkyl (or cyclo-alkyl)thio-benzyloxopyrimidines), DATNOs (dihydro-alkylthionaphthylmethyl-oxopyrimidines) and F2-S-DABOs (dihydro-alkyl (or cyclo-alkyl)thio-2,6-difluorobenzyl-oxopyrimidines) have been prepared and tested as anti-HIV-1 agents. S-DABO derivatives bearing at C-6 position monosubstituted phenylmethyl or heteroarylmethyl units have also been synthesized. 2-Alkylthio-3,4-dihydropyrimidin-4(3 H)-one derivatives of F2- S-DABO series bearing small alkyl groups at C-5 proved to be potent inhibitors of HIV-1 replication in vitro with selectivity indexes ranging from 250 to <2500

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Initial Public Offerings and the Firm Location

The firm geographic location matters in IPOs because investors have a strong preference for newly issued local stocks and provide abnormal demand in local offerings. Using equity holdings data for more than 53,000 households, we show the probability to participate to the stock market and the proportion of the equity wealth is abnormally increasing with the volume of the IPOs inside the investor region. Upon nearly the universe of the 167,515 going public and private domestic manufacturing firms, we provide consistent evidence that the isolated private firms have higher probability to go public, larger IPO underpricing cross-sectional average and volatility, and less pronounced long-run under-performance. Similar but opposite evidence holds for the local concentration of the investor wealth. These effects are economically relevant and robust to local delistings, IPO market timing, agglomeration economies, firm location endogeneity, self-selection bias, and information asymmetries, among others. Findings suggest IPO waves have a strong geographic component, highlight that underwriters significantly under-estimate the local demand component thus leaving unexpected money on the table, and support state-contingent but constant investor propensity for risk

Approximation of fixed points by Cesàro's means of iterates

Sia K un sottoinsieme chiuso e convesso di uno spazio di Banach uniformemente convesso, e sia T un\textquoteright{}applicazione non espansiva di K in sé, dotata di punti fissi. In questa Nota si dimostra che, se $x\epsilon K$ e $\left\{ T^{n}(x)\right\}$ ammette punti limite, la successione delle medie secondo Cesaro di $\left\{ T^{n}(x)\right\}$ converge a un punto fìsso di T. Si osserva inoltre che il risultato precedente vale anche sotto condizioni più generali e si danno controesempi per il caso di mappe quasi non espansive.Let K be a closed convex subset of a uniformly convex Banach space and let T a nonexpansive selfmapping of K which has at least one fixed point. In this Paper we prove that, if $x\epsilon K$ and $\left\{ T^{n}(x)\right\}$ has some limit point, then the sequence of the Cesaro\textquoteright{}s means of $\left\{ T^{n}(x)\right\}$converges to a fixed point of T. We remark moreover that the above result still holds under more general conditions and we give some counter-examples for quasi-nonexpansive mappings

Estudio cualitativo sobre la construcción del vínculo de pareja : en parejas heterosexuales adictas a la marihuana : un enfoque pos-modernista

Tesis (Psicología)La presente investigación explora y describe la construcción del vínculo que sustentan y expresan cuatro parejas heterosexuales adictas a la marihuana (entre 21 y 30 años), desde una visión posmodernista. Para los objetivos de nuestra investigación se abordaron las siguientes dimensiones: género, vínculo, adicción, construcción pareja adictiva y relación actual de pareja; sustentado por los postulados teóricos basados en el Construccionismo Social. Esto con el propósito de poder conocer y describir los procesos que ocurren, además de los significados que otorgan estas parejas al fenómeno de lo que para ellos es la adicción y su construcción de pareja. La metodología utilizada fue de corte cualitativo, utilizando un diseño que cumplía a cabalidad con las condiciones de nuestro modelo de investigación. Por ende, se aplicó una entrevista semi-estructurada como medio de recolección de datos, lo que nos permitió conocer y analizar el discurso de cada participante. Los resultados revelan una clara distinción en los sujetos entrevistados, de que la marihuana no es un factor constitutivo y esencial en la construcción del vínculo de estas parejas, muy por el contrario, el amor , el cariño, la aceptación del otro y el compartir juntos aparecen como las premisas fundamentales. Ciertamente, este estudio preliminar y exploratorio no pretende haber hecho hallazgos definitivos, pero la riqueza y sutileza de las experiencias y vivencias de ser pareja que fue posible rescatar en nuestros sujetos entrevistados, son un incentivo enorme para continuar profundizando en esta línea de trabajo; ya sea a nivel teórico o a nivel clínico

Remarks on asymptotic and Chebyshev centers

Let X be a Banach space and K a subset of X. Two related concepts have proved quite useful in the study of fixed point theory for mappings of nonexpansive type: the asymptotic center of a sequence in X relative to K, and the Cheby,,:hev center of a set $ in X relative to K. In Section 1 below we compare • symptotic centers of sequences and nets, and in Section 2 we make an observation regarding continuity of Chebyshev centers which extends a result of Mach [12] from a uniformly convex setting to a &quot;nearly uniform convex &quot; setting. We use the notation B(x; r) to denote the closed unit ball centered at x 6 X with radius r&gt; 0. Asymptotic Centers. The concept of asymptoti center was introduced by Edelstein in [1] and extended by Lim to apply to nets in [9]. We recall the definitions: Let A be a directed set and {x•, • 6 A) a bounded net in X. Set ry({Xo}) = limsup y- xo I---- li•m{sup { y- xz]] ß/3&gt; c•}}; rK({x•,}) = inf{rv({xo}) : y e K); A•({•o}) = { • e a:: •({•}) = •({•})}. The number rK({X•}) is called the asymptotic radius of {x•} in K and the (possibly empty) set Aa:({x•}) the asymptoti center of {x•} in K. Since A({x •}) is the set of minimizers of the weakly lower semicontinuous function •: K- • It defined by •(y) = limsup • Ily- x•11, it follows that if K is weakly compact and convex, then Aa:({x•}) is a nonempty closed and convex subset of K. For the present discussion we shall assume K is a fixed weakly compact convex set in X and drop the subscripts and references to K

(chlorothienyl)[(dihydrooxazolyl)phenoxy]butanone or [(carboxyphenoxy)oxopentyl]methyl-1H-pyrrolecarboxaldehyde and analogs, methods for their preparation and their use for the inhibition of rhinovirus infections

Compds. for the treatment of rhinovirus infections are claimed.; such compds. are e.g. 1-(2-chloro-5-thienyl)-4-[4-(4,5-dihydro-2-oxazolyl)phenoxy]-1-butanone (I) or 4-[5-[4-(carboxyphenoxy)]-1-oxopentyl]-1-methyl-1H-pyrrole-2-carboxaldehyde (II). Condensation of 2-chloro-5-(5-chloropentanoyl)thiophene with 2-(4-hydroxyphenyl)-4,5-dihydrooxazole gave I (97% yield). I inhibited HRV-14 selectively. [on SciFinder(R)