Clubbing: otherness and the politics of experience

This thesis investigates experiences of contemporary club and dance cultures in the context of postmodern aestheticisation. Its object of study is the phantasmatic and discursive complex of otherness, transgression and freedom in which contemporary British club and dance cultures are embedded. It argues that clubbing experiences are fabricated through this complex of otherness, which articulates a politics, of experience. This refers to contexts that structure experiences of dance cultures. In this respect, the thesis considers the contexts of class, gender and sexuality, structures of the production and consumption of clubbing, the institutional regulation and ordering of club spaces and media discourses and imagery. In analysing socially contextualised meanings of this otherness it examines how these become relevant for the construction of identity. The theoretical agenda of the thesis is to explore aestheticisation as a condition for and as a form of identity construction. This engages with changing modes of reflexivity in the construction of reality and reformulates the issues of style, identity and authenticity. The empirical analysis focuses on modes of reflexivity in constructing realities of sexuality, body and self. Research of this study was carried out in London. The qualitative research design comprised narrative interviewing and ethnographic participation in clubs in central London. A criterion for sampling and for the selection of clubs and interviewees was the dimension of sexuality and the sexual differentiation and codification of club spaces. The interview sample consists of twenty-three interviews with people of mixed genders, sexualities and cultural, national backgrounds

In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice

Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs. Opioids are the mainstay for the treatment of moderate to severe pain. However, opioid pain medications also cause detrimental side effects, thus highlighting the need of innovative and safer analgesics. Opioids mediate their actions via the activation of opioid receptors, with the mu-opioid receptor as the primary target for analgesia, but also for side effects. One long-standing focus of drug discovery is the pursuit for new opioids exhibiting a favorable dissociation between analgesia and adverse effects. In this study, we describe the in vitro and in vivo pharmacological profiles of the 14-O-phenylpropyl substituted analog of the mu-opioid agonist 14-O-methyloxymorphone (14-OMO). The consequence of the substitution of the 14-O-methyl in 14-OMO with a 14-O-phenylpropyl group on in vitro binding and functional activity, and in vivo behavioral properties (nociception and gastrointestinal motility) was investigated. In binding studies, 14-O-phenylpropyloxymorphone (POMO) displayed very high affinity at mu-, delta-, and kappa-opioid receptors (Ki values in nM, mu:delta:kappa = 0.073:0.13:0.30) in rodent brain membranes, with complete loss of mu-receptor selectivity compared to 14-OMO. In guinea-pig ileum and mouse vas deferens bioassays, POMO was a highly efficacious and full agonist, being more potent than 14-OMO. In the [35S]GTPγS binding assays with membranes from CHO cells expressing human opioid receptors, POMO was a potent mu/delta-receptor full agonist and a kappa-receptor partial agonist. In vivo, POMO was highly effective in acute thermal nociception (hot-plate test, AD50= 0.7 nmol/kg) in mice after subcutaneous administration, with over 70- and 9000-fold increased potency than 14-OMO and morphine, respectively. POMO-induced antinociception is mediated through the activation of the mu-opioid receptor, and it does not involve delta- and kappa-opioid receptors. In the charcoal test, POMO produced fourfold less inhibition of the gastrointestinal transit than 14-OMO and morphine. In summary, POMO emerges as a new potent mixed mu/delta/kappa-opioid receptor agonist with reduced liability to cause constipation at antinociceptive doses

Beyond the Production-Consumption Divide: Conceptual Tools for the Analysis of Modes and Processes of Provision

Within historical as well as sociological research a gulf exists between the study of matters of production, marketing and distribution on the one hand and questions of consumption and the use of goods in social practices on the other hand. Developing theoretical frameworks and methodologies that cut across this divide remains an ongoing challenge. This article considers different conceptual frameworks that open up an institutional perspective on the social and economic organization of production and consumption. Offering a close examination, in particular, of the mode of provision-approach through comparison with antecedent perspectives such as Polanyi’s conceptual scheme for studying the substantive economy, this article refines these tools and outlines their possible applications within empirical and historical research.Within historical as well as sociological research a gulf exists between the study of matters of production, marketing and distribution on the one hand and questions of consumption and the use of goods in social practices on the other hand. Developing theoretical frameworks and methodologies that cut across this divide remains an ongoing challenge. This article considers different conceptual frameworks that open up an institutional perspective on the social and economic organization of production and consumption. Offering a close examination, in particular, of the mode of provision-approach through comparison with antecedent perspectives such as Polanyi’s conceptual scheme for studying the substantive economy, this article refines these tools and outlines their possible applications within empirical and historical research

A European research agenda for somatic symptom disorders, bodily distress disorders, and functional disorders: Results of an estimate-talk-estimate delphi expert study

Background: Somatic Symptom Disorders (SSD), Bodily Distress Disorders (BDD) and functional disorders (FD) are associated with high medical and societal costs and pose a substantial challenge to the population and health policy of Europe. To meet this challenge, a specific research agenda is needed as one of the cornerstones of sustainable mental health research and health policy for SSD, BDD, and FD in Europe. Aim: To identify the main challenges and research priorities concerning SSD, BDD, and FD from a European perspective. Methods: Delphi study conducted from July 2016 until October 2017 in 3 rounds with 3 workshop meetings and 3 online surveys, involving 75 experts and 21 European countries. EURONET-SOMA and the European Association of Psychosomatic Medicine (EAPM) hosted the meetings. Results: Eight research priorities were identified: (1) Assessment of diagnostic profiles relevant to course and treatment outcome. (2) Development and evaluation of new, effective interventions. (3) Validation studies on questionnaires or semi-structured interviews that assess chronic medical conditions in this context. (4) Research into patients preferences for diagnosis and treatment. (5) Development of new methodologic designs to identify and explore mediators and moderators of clinical course and treatment outcomes (6). Translational research exploring how psychological and somatic symptoms develop from somatic conditions and biological and behavioral pathogenic factors. (7) Development of new, effective interventions to personalize treatment. (8) Implementation studies of treatment interventions in different settings, such as primary care, occupational care, general hospital and specialty mental health settings. The general public and policymakers will benefit from the development of new, effective, personalized interventions for SSD, BDD, and FD, that will be enhanced by translational research, as well as from the outcomes of research into patient involvement, GP-patient communication, consultation-liaison models and implementation. Conclusion: Funding for this research agenda, targeting these challenges in coordinated research networks such as EURONET-SOMA and EAPM, and systematically allocating resources by policymakers to this critical area in mental and physical well-being is urgently needed to improve efficacy and impact for diagnosis and treatment of SSD, BDD, and FD across Europe

Leave Me Alone With Your Symptoms! Social Exclusion at the Workplace Mediates the Relationship of Employee's Mental Illness and Sick Leave

Although a substantial part of employees suffers from a mental illness, the work situation of this population still is understudied. Previous research suggests that people with a mental illness experience discrimination in the workplace, which is known to have detrimental effects on health. Building on the stereotype content model and allostatic load theory, the present study investigated whether employees with a mental illness become socially excluded at the workplace and therefore show more days of sick leave. Overall, 86 employees diagnosed with a mental disorder were interviewed and completed online-surveys. Path analyses supported the hypotheses, yielding a serial mediation: The interview-rated severity of the mental disorder had an indirect effect on the days of sick leave, mediated by the symptomatic burden and the social exclusion at the workplace. In the light of the costs associated with absenteeism the present paper highlights the harmfulness of discrimination. Organizations and especially supervisors need to be attentive for signs of exclusion within their teams and try to counteract as early as possible

Clubbing : otherness and the politics of experience

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Reactionaries of the lectern: Universalism, anti-empiricism and corporatism in Austrian (and German) social theory

This article discusses one early manifestation of a recurring theme in social theory and sociology: the relationship between general ('universal' or 'grand') theory and empirical research. For the early critical theorists, empiricism and positivism were associated with technocratic domination. However, there was one place where the opposite view prevailed: science and empiricism were viewed as forces of social and political progress and speculative social theory as a force of reaction. That place was Red Vienna of the 1920s and early 1930s. We examine how this view came to be widespread among Austro-Marxists, empirical researchers and some members of the Vienna Circle. It focuses on the arguments and institutional power of their opponents: reactionary, universalistic and corporatist social theorists. The debate between Catholic corporatist theory and its empiricist critics is located not merely in Vienna but also within wider debates in the German-speaking world. Finally, we seek to link these lesser-known positions to more familiar strands of social thought, namely, those associated with Weber and, more briefly, Durkheim and Elias