New CMB Power Spectrum Constraints from MSAMI

We present new cosmic microwave background (CMB) anisotropy results from the combined analysis of the three flights of the first Medium Scale Anisotropy Measurement (MSAM1). This balloon-borne bolometric instrument measured about 10 square degrees of sky at half-degree resolution in 4 frequency bands from 5.2 icm to 20 icm with a high signal-to-noise ratio. Here we present an overview of our analysis methods, compare the results from the three flights, derive new constraints on the CMB power spectrum from the combined data and reduce the data to total-power Wiener-filtered maps of the CMB. A key feature of this new analysis is a determination of the amplitude of CMB fluctuations at $\ell \sim 400$. The analysis technique is described in a companion paper by Knox.Comment: 9 pages, 6 included figure

A characteristic lengthscale causes anomalous size effects and boundary programmability in mechanical metamaterials

The architecture of mechanical metamaterialsis designed to harness geometry, non-linearity and topology to obtain advanced functionalities such as shape morphing, programmability and one-way propagation. While a purely geometric framework successfully captures the physics of small systems under idealized conditions, large systems or heterogeneous driving conditions remain essentially unexplored. Here we uncover strong anomalies in the mechanics of a broad class of metamaterials, such as auxetics, shape-changers or topological insulators: a non-monotonic variation of their stiffness with system size, and the ability of textured boundaries to completely alter their properties. These striking features stem from the competition between rotation-based deformations---relevant for small systems---and ordinary elasticity, and are controlled by a characteristic length scale which is entirely tunable by the architectural details. Our study provides new vistas for designing, controlling and programming the mechanics of metamaterials in the thermodynamic limit.Comment: Main text has 4 pages, 4 figures + Methods and Supplementary Informatio

Dupilumab provides rapid and sustained improvement in SCORAD outcomes in adults with moderate-to-severe atopic dermatitis: combined results of four randomized phase 3 trials

Background:Dupilumab, a first-in-class therapy targeting the two key cytokines involved in the persistent underlying inflammatory pathway in atopic dermatitis (AD), is approved for treatment of moderate-to-severe AD in Europe, USA, Japan and several other countries. Objective:To assess dupilumab effects on SCORing Atopic Dermatitis (SCORAD) and component scores (objective and subjective SCORAD) over time in adults with moderate-to-severe AD. Methods:Thispost hocanalysis included 2,444 patients in four placebo-controlled, double-blind, randomized, phase 3 trials. SOLO 1 and 2 (NCT02277743; NCT02277769) evaluated 16 weeks of dupilumab monotherapy against placebo. CAFe (NCT02755649) and CHRONOS (NCT02260986) evaluated dupilumab with concomitant topical corticosteroids (TCS) against TCS alone for 16 and 52 weeks, respectively. Results:2,444 patients randomized to treatment in SOLO 1 and 2 (N = 1,379), CAFe (N = 325) and CHRONOS (N = 740) were analyzed. Dupilumab treatment significantly improved overall SCORAD and individual components as early as Week 1 or 2, with significant and clinically meaningful differences vs. control through end of treatment (p < .0001). These results occurred irrespective of dupilumab regimen, 300 mg subcutaneously weekly or every 2 weeks. Conclusions:In four large phase 3 trials in adults with moderate-to-severe AD, dupilumab treatment with or without concomitant TCS resulted in rapid and sustained improvements in all SCORAD outcomes vs. placebo or TCS alone

Static non-reciprocity in mechanical metamaterials

Reciprocity is a fundamental principle governing various physical systems, which ensures that the transfer function between any two points in space is identical, regardless of geometrical or material asymmetries. Breaking this transmission symmetry offers enhanced control over signal transport, isolation and source protection. So far, devices that break reciprocity have been mostly considered in dynamic systems, for electromagnetic, acoustic and mechanical wave propagation associated with spatio-temporal variations. Here we show that it is possible to strongly break reciprocity in static systems, realizing mechanical metamaterials that, by combining large nonlinearities with suitable geometrical asymmetries, and possibly topological features, exhibit vastly different output displacements under excitation from different sides, as well as one-way displacement amplification. In addition to extending non-reciprocity and isolation to statics, our work sheds new light on the understanding of energy propagation in non-linear materials with asymmetric crystalline structures and topological properties, opening avenues for energy absorption, conversion and harvesting, soft robotics, prosthetics and optomechanics.Comment: 19 pages, 3 figures, Supplementary information (11 pages and 5 figures

The COBE Diffuse Infrared Background Experiment Search for the Cosmic Infrared Background: IV. Cosmological Implications

In this paper we examine the cosmological constraints of the recent DIRBE and FIRAS detection of the extragalactic background light between 125-5000 microns on the metal and star formation histories of the universe.Comment: 38 pages and 9 figures. Accepted for publications in The Astrophysical Journa

Endomorphisms of superelliptic jacobians

Let K be a field of characteristic zero, n>4 an integer, f(x) an irreducible polynomial over K of degree n, whose Galois group is doubly transitive simple non-abelian group. Let p be an odd prime, Z[\zeta_p] the ring of integers in the p-th cyclotomic field, C_{f,p}:y^p=f(x) the corresponding superelliptic curve and J(C_{f,p}) its jacobian. Assuming that either n=p+1 or p does not divide n(n-1), we prove that the ring of all endomorphisms of J(C_{f,p}) coincides with Z[\zeta_p].Comment: Several typos have been correcte

Whole Disk Observations of Jupiter, Saturn and Mars in Millimeter--Submillimeter Bands

Whole disk brightness ratios for Jupiter, Saturn, and Mars are reported at 5.7, 9.5, 16.4, and 22.5 cm$^{-1}$. Using models for the brightness temperature of Mars, the whole disk brightness temperatures for Jupiter and Saturn are also given for the four frequencies.Comment: 13 pages, LaTeX+aasms4 package, 2 included PostScript figures. Submitted to Ap.J Letter

New Cosmic Microwave Background Power Spectrum Constraints from MSAM1

This is the published version, also available here: http://dx.doi.org/10.1086/308535.We present new cosmic microwave background (CMB) anisotropy results from the combined analysis of the three flights of the first Medium Scale Anisotropy Measurement (MSAM1). This balloon-borne bolometric instrument measured about 10 deg2 of sky at half-degree resolution in four frequency bands from 5.2 to 20 cm-1 with a high signal-to-noise ratio. Here we present an overview of our analysis methods, compare the results from the three flights, derive new constraints on the CMB power spectrum from the combined data, and reduce the data to total power Wiener-filtered maps of the CMB. A key feature of this new analysis is a determination of the amplitude of CMB fluctuations at l ~ 400. The analysis technique is described in a companion paper (L. Knox)