57 research outputs found
Influência de Trichoderma spp. sobre o crescimento micelial de Colletotrichum gloeosporioides em açaí.
Bacillus sphaericus Binary Toxin Elicits Host Cell Autophagy as a Response to Intoxication
Bacillus sphaericus strains that produce the binary toxin (Bin) are highly toxic to Culex and Anopheles mosquitoes, and have been used since the late 1980s as a biopesticide for the control of these vectors of infectious disease agents. The Bin toxin produced by these strains targets mosquito larval midgut epithelial cells where it binds to Cpm1 (Culex pipiens maltase 1) a digestive enzyme, and causes severe intracellular damage, including a dramatic cytoplasmic vacuolation. The intoxication of mammalian epithelial MDCK cells engineered to express Cpm1 mimics the cytopathologies observed in mosquito enterocytes following Bin ingestion: pore formation and vacuolation. In this study we demonstrate that Bin-induced vacuolisation is a transient phenomenon that affects autolysosomes. In addition, we show that this vacuolisation is associated with induction of autophagy in intoxicated cells. Furthermore, we report that after internalization, Bin reaches the recycling endosomes but is not localized either within the vacuolating autolysosomes or within any other degradative compartment. Our observations reveal that Bin elicits autophagy as the cell's response to intoxication while protecting itself from degradation through trafficking towards the recycling pathways
Health self-assessment by hemodialysis patients in the Brazilian Unified Health System
Confiabilidade dos dados do Sistema de Informações sobre Nascidos Vivos em Teresina, Estado do Piauí, Brasil - 2002
Comparative genomics reveals Lysinibacillus sphaericus group comprises a novel species
Evaluation of quality of life in adults with chronic health conditions: the role of depressive symptoms
- …