2 research outputs found
Aliskiren improves renal morphophysiology and inflammation in Wistar rats with 2K1C renovascular hypertension
Hypertension is characterized by persistent
elevated blood pressure levels, one of the leading causes
of death in the world. Renovascular hypertension
represents the most common cause of secondary
hypertension, and its progress is associated with
overactivation of the renin angiotensin aldosterone
system (RAAS), causing systemic and local changes.
Aliskiren is a renin-inhibiting drug that optimizes RAAS
suppression. In this sense, the objective of the present
study was to analyze the morphophysiology of the left
kidney in Wistar rats with renovascular hypertension
after treatment with Aliskiren. Parameters such as
systolic blood pressure, urinary creatinine and protein
excretion, renal cortex structure and ultrastructure,
fibrosis and tissue inflammation were analyzed. Our
results showed that the hypertensive animals treated with
Aliskiren presented a reestablishment of blood pressure,
expression of renin, and renal function, as well as a
remodeling of morphological alterations through the
reduction of fibrosis. The treatment regulated the
laminin expression and decreased pro-inflammatory
cytokines, restoring the integrity of the glomerular
filtration barrier. Therefore, our findings suggest that
Aliskiren has a renoprotective effect acting on the
improvement of the morphology, physiology and
pathology of the renal cortex of animals with
renovascular hypertensio
Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension
Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension, and its progress is associated with overactivation of the renin-angiotensin-aldosterone system (RAAS). Aliskiren is a renin inhibiting drug that suppresses RAAS and culminates in decreased renin release, plasma angiotensin II concentration, and inhibition of aldosterone secretion. In this sense, the aim of the present study was to analyze the structural and ultrastructural morphophysiology of the adrenal glomerular zone, after treatment with aliskiren in Wistar rats with 2K1C hypertension. Parameters as structure and ultrastructure of the adrenal glomerular zone, cellular apoptosis, nuclear cell proliferation, and AT1 receptor expression were analyzed by immunostaining and electron microscopy. Our results showed that the hypertensive animals treated with aliskiren presented a reestablishment of AT1 receptor expression and decrease in apoptosis and autophagy. In addition, treatment with aliskiren improves the cell aspects in the adrenal glomerular zone, evidenced by ultrastructural analysis through preserved nuclei and well-developed mitochondria. Therefore, our evidence suggests that aliskiren has a beneficial effect on the adrenal glomerular zone remodeling in animals with renovascular hypertension