EDUCAÇÃO EM DIABETES COM DEFICIENTES VISUAIS: UMA EXPÊRIÊNCIA UNIVERSITÁRIA

Experience developed with visually impaired people in the Association for the Blind in the city of Fortaleza, Ceará (Brazil). A conference for 40 people was held about the concept, risk factors and treatment of diabetes followed by selection, interview, and verification of anthropometrics measures and capillary glycemia. In this phase 26 people participated. The values obtained related to capillary glycemia by strip varied from 74 to 193 mg/dl. Age index was from 11 to 57 years with 17 females and 9 males. The time of the most recent meal varied between 2 and 6 hours. Among risk factors faced: 20 people reported being sedentary, 10 with a history of diabetes in the family; 4 being overweight y 2 with hypertension. The conclusion we arrive at is that it is of fundamental importance to inform and prevent diabetes in this type of patients.  Relato sobre la experiencia desarrollada con deficientes visuales en la Asociación de Ciegos del Estado de Ceará, en Fortaleza. Se realizó una conferencia para 40 personas, en la que se debatió sobre el concepto, los factores de riesgo y el tratamiento de diabetes, seguida de selección junto con entrevista, verificación de medidas antropométricas y glicemia capilar. En esta fase participaron 26 personas. Los valores que se obtuvieron con relación a glicemia capilar por la cinta variaron de 74 a 193 mg/dl. El índice de edad abarcó el intervalo entre los 11 a 57 años, 17 del sexo femenino y 9 del masculino. El horario de la última comida varió entre 2 y 6 horas. Entre los factores de riesgo que se abordaron, 20 personas  se declararon  sedentarias; 10 con historia de diabetes en la familia; 4 presentaron peso superior a lo normal y 2 hipertensos. La conclusión a que se llega es que es de fundamental importancia  promover y prevenir  la diabetes con este tipo de pacientes.Relato de experiência desenvolvida com deficientes visuais na Associação dos Cegos do Estado do Ceará, em Fortaleza. Realizou-se uma palestra para 40 pessoas na qual se abordou conceito, fatores de risco e tratamento do diabetes, seguida de triagem, com entrevista, verificação de medidas antropométricas e glicemia capilar. Desta fase, participaram 26 pessoas. Os valores obtidos de glicemia capilar pela fita variaram de 74 a 193 mg/dl. A faixa etária abrangeu o intervalo de 11 a 57 anos, 17 do sexo feminino e 9 do masculino. O horário da última refeição variou de 2 a 6 horas. Sobre fatores de riscos abordados, 20 indivíduos alegaram ser sedentários; 10 com história de diabetes na família; quatro com peso acima da normalidade e dois hipertensos. Pode-se concluir que a promoção e prevenção do diabetes são de fundamental importância para essa clientela. &nbsp

Evaluation of neuromotor development by means of the Harris Infant Neuromotor Test

Objective: To investigate the neuromotor development of at-risk children between three and 12 months of life, administering the Brazilian version of the Harris Infant Neuromotor Test (HINT).Method: A longitudinal study, with 78 children and 76 parents/guardians discharged from a neonatal intensive care unit in Fortaleza-CE/Brazil. Two instruments were administered: HINT and a socioeconomic questionnaire, between July/2009 to August/2010. Data from 55 preterm and 23 term children were analyzed. Results: The final mean scores ranged from 14.6 to 25.2 and from 11.2 to 24.7, for preterm and term, respectively, showing that 91% of children demonstrated good neuromotor performance; seven premature infants showed alterations which led to the referral of three children to a specialized clinic for examination and diagnostics.Conclusion: The test allowed nurses to assess infant development, identify deviations early, and plan interventions

A diarylamine derived from anthranilic acid inhibits ZIKV replication

Zika virus (ZIKV) is a mosquito-transmitted Flavivirus, originally identified in Uganda in 1947 and recently associated with a large outbreak in South America. Despite extensive efforts there are currently no approved antiviral compounds for treatment of ZIKV infection. Here we describe the antiviral activity of diarylamines derived from anthranilic acid (FAMs) against ZIKV. A synthetic FAM (E3) demonstrated anti-ZIKV potential by reducing viral replication up to 86%. We analyzed the possible mechanisms of action of FAM E3 by evaluating the intercalation of this compound into the viral dsRNA and its interaction with the RNA polymerase of bacteriophage SP6. However, FAM E3 did not act by these mechanisms. In silico results predicted that FAM E3 might bind to the ZIKV NS3 helicase suggesting that this protein could be one possible target of this compound. To test this, the thermal stability and the ATPase activity of the ZIKV NS3 helicase domain (NS3Hel) were investigated in vitro and we demonstrated that FAM E3 could indeed bind to and stabilize NS3Hel