Healthcare Services Demand in Post-disaster Settings: The 2014 Earthquake in Ludian County, Yunnan Province, China

© 2016, The Author(s). Healthcare relief teams dispatched to rural areas often face difficulties due to limited initial and ongoing health information in the affected community. The present study investigated patterns of healthcare service demand for a rural displaced population in a post-disaster situation. Three weeks after the 2014 Ludian County earthquake, the Institute for Disaster Management and Reconstruction (IDMR) at Sichuan University and Hong Kong Polytechnic University organized a disaster nursing team to support the rural community in Longtoushan, at the epicenter of the earthquake. A cross-sectional, records-based study of 2484 records obtained from a temporary hospital in Longtoushan (for the period of 14 Septemberâ1 October 2014) was conducted. The daily number of records by patientsâ sociodemographic characteristics and medical diagnoses were plotted on a time series graph to explore the temporal change during the study period. Findings indicate that healthcare service demand from younger age groups was higher than that of the older adult group. Three major health problems were observed: respiratory disease, skin problems, and ear, eye, and throat (EET) problems. All of these very real health problems are chronic issues that require long-term care. They are not health issues directly related to the disaster emergency itself. Yet disaster relief nursing teams were selected on the basis of their ability to cope primarily with traumatic disaster-related injuries. The existing practice of teaming up disaster relief professions might not be optimal. To better understand the healthcare needs of a displaced population, short- and long-term planning is needed. Planning will allow disaster response professionals to better organize and deploy healthcare personnel to manage the above-listed problems in a post-disaster situation.Link_to_subscribed_fulltex

Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis

OBJECTIVE: Pulmonary hypertension is a lethal disease characterized by pulmonary vascular remodeling and is mediated by abnormal proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). Platelet-derived growth factor BB (PDGF-BB) is the most potent mitogen for PASMCs and is involved in vascular remodeling in pulmonary hypertension development. Therefore, the objective of our study is to identify novel mechanisms underlying vascular remodeling in pulmonary hypertension. METHODS: We explored the effects and mechanisms of PTPRD downregulation in PASMCs and PTPRD knockdown rats in pulmonary hypertension induced by hypoxia. RESULTS: We demonstrated that PTPRD is dramatically downregulated in PDGF-BB-treated PASMCs, pulmonary arteries from pulmonary hypertension rats, and blood and pulmonary arteries from lung specimens of patients with hypoxic pulmonary arterial hypertension (HPAH) and idiopathic PAH (iPAH). Subsequently, we found that PTPRD was downregulated by promoter methylation via DNMT1. Moreover, we found that PTPRD knockdown altered cell morphology and migration in PASMCs via modulating focal adhesion and cell cytoskeleton. We have demonstrated that the increase in cell migration is mediated by the PDGFRB/PLCγ1 pathway. Furthermore, under hypoxic condition, we observed significant pulmonary arterial remodeling and exacerbation of pulmonary hypertension in heterozygous PTPRD knock-out rats compared with the wild-type group. We also demonstrated that HET group treated with chronic hypoxia have higher expression and activity of PLCγ1 in the pulmonary arteries compared with wild-type group. CONCLUSION: We propose that PTPRD likely plays an important role in the process of pulmonary vascular remodeling and development of pulmonary hypertension in vivo

Research progress and breakthrough directions of the key technical fields for large scale and efficient exploration and development of coalbed methane in Xinjiang

The Xinjiang Uygur Autonomous Region has presented the expected resource conditions and work foundations for a large-scale coalbed methane (CBM) exploration and development, which shows that its CBM resources below the depth of 2000 m are 7.5 trillion m3, 450 CBM wells have been constructed, and the annual gas production has approached to 80 million m3. Xinjiang has put forward the goal of the annual CBM production of 2.5 billion m3 in 2025. Therefore, the large-scale and efficient development of CBM in Xinjiang has become an urgent and significant demand. In this paper, the main research progresses of Xinjiang CBM made in five key technical fields have been systematically summarized, including the CBM enrichment model and area optimization technology, the prediction and detection technology for sweet spot distribution, the technological strategy of the accelerated rolling development and rapid increase of reserves and productions, the geological adaptation technology system, and the cooperative exploration and development of CBM with coal, oil and gas. Then, the potential breakthrough directions have been analyzed and proposed. Research has shown that the coal reservoirs in Xinjiang show the unique geological characteristics of CBM, including widely developed multi-thick coal seams, low rank coal development, the frequent occurrence of steep coal seams, the significant deformation and structural control of coal bodies, complex hydrologic and outcrop conditions, and the gas-bearing and physical properties with three “low” (low gas content, methane concentration, and gas saturation) and five “high” (high gas intensity, porosity, stress change, reservoir pressure change, and permeability change). The Xinjiang CBM has multiple genetic types and enrichment models, including biogenic mechanism, thermogenic mechanism, and biogenic-thermogenic composite genetic mechanism, etc., and their corresponding enrichment models. Biogenic gas reservoirs or biogenic gas contribute widely. The distribution and occurrence patterns of CBM in Xinjiang show some significant differences between foreland basin and intermountain basin. Therefore, the first breakthrough direction is to innovate and form the scientific evaluation based on the principle of “two separation” (low-rank and middle- and high-rank; shallow and deep coal) and “two combination” (geological and engineering evaluation; multivariate data) and the precise target optimization technology based on “machine learning + three-dimensional geological modeling”. The sweet spot of deep CBM/CMG (coal measure gas) in Xinjiang is mainly the uplift of the depression in the basin, the depression of the uplift in the basin, and the slope around the basin margin. The potential well location is the structurally high position, and the potential reservoir is the fissure-developed primary structure coal seam or pore and fissure-developed coal bearing sand conglomerate reservoir. Then, the second breakthrough direction is the sweet spot prediction and exploration technology for deep CBM/CMG based on “new method of geophysics, rock physics and rock mechanics stratigraphy” and “new concept of geological and engineering sweet spot”. The basic principles of the accelerated rolling development are low-risk, short-cycle, high-efficiency, and multi-batch project deployment. The technical strategies of the rapid increase of CBM reserves and productions in the middle and shallow coal seams include the new well layout and construction in the new optimized block and the old well reconstruction for the increase of CBM production in the mature block. While this strategy for the deep coal seam is to give priority to deployment and development in the sweet spot in the deep but gentle slope in the large basin and the uplift in the basin. Then, the third breakthrough direction is the engineering deployment methods and technical strategies for the scientific accelerated rolling development, and efficient and rapid increase of the gas reserves and productions. The important progresses have been made in the engineering technologies of Xinjiang CBM, such as the differential optimization and deployment of the well type and pattern, the drilling and cementing with a low reservoir damage, the high reliability logging and well testing, the efficient staged fracturing with the multi-well types, and the drainage control with the low casing pressure and controlled pressure. The fourth breakthrough direction is to develop and construct a geological adaptability technology system for a large-scale and efficient exploration and development of CBM in Xinjiang. For the middle and shallow CBM and coal cooperative exploration and development, the gas extraction followed by coal mining, the co-extraction of CBM and coal, and the co-extraction of CBM and in-situ oil-rich coal should be conducted. For the deep CBM, oil, and gas cooperative exploration and development, the development of coal measure superimposed gas reservoir, the co-exploration and co-extraction of CBM and CMG, and the exploration and development of the whole petroleum system in coal-bearing sequence should be conducted. These cooperative exploration and development of deep CBM, oil, and gas is the fifth breakthrough direction, whose developments have been considered and explored. The results of this study are expected to provide the technical support and engineering decision reference for a large-scale and efficient exploration and development of CBM in Xinjiang

Evaluating the effectiveness of a stroke education programme in Wuhan City of China

published_or_final_versionSocial Work and Social AdministrationMasterMaster of Philosoph