Uniportal video-assisted thoracoscopic lobectomy

published_or_final_versio

Reasons not to perform Uniportal VATS lobectomy

Session: Evidence and Training: paper no. SP1-3published_or_final_versio

Primary pneumothorax: Should surgery be offered after the first episode?

published_or_final_versio

Does Abrasion Pleurodesis increase the Morbidity of Video Assisted Thoracic Surgery for Primary Pneumothorax?

Posters - Topic 6: Thoracic 2 - Pain, Pleura and Port Approaches: no. P62OBJECTIVE: Pneumothorax surgery is a frequently used model to investigate the impact of surgical approach on postoperative morbidity. However, the criticism that abrasion pleurodesis during such surgery may confound results by introducing additional morbidity has not been specifically investigated ...postprin

Uniportal thoracoscopic lobectomy for intralobar pulmonary sequestration

published_or_final_versio

Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas

BACKGROUND: Large tumor suppressor 2 (LATS2) gene is a putative tumor suppressor gene with potential roles in regulation of cell proliferation and apoptosis in lung cancer. The aim of this study is to explore the association of aberrant LATS2 expression with EGFR mutation and survival in lung adenocarcinoma (AD), and the effects of LATS2 silencing in both lung AD cell lines. METHODS: LATS2 mRNA and protein expression in resected lung AD were correlated with demographic characteristics, EGFR mutation and survival. LATS2-specific siRNA was transfected into four EGFR wild-type (WT) and three EGFR mutant AD cell lines and the changes in LATS2 expression and relevant signaling molecules before and after LATS2 knockdown were assayed. RESULTS: Fifty resected lung AD were included (M:F=23:27, smokers:non-smokers=19:31, EGFR mutant:wild-type=21:29) with LATS2 mRNA levels showed no significant difference between gender, age, smoking and pathological stages while LATS2 immunohistochemical staining on an independent set of 79 lung AD showed similar trend. LATS2 mRNA level was found to be a significant independent predictor for survival status (disease-free survival RR=0.217; p=0.003; Overall survival RR=0.238; p=0.036). siRNA-mediated suppression of LATS2 expression resulted in augmentation of ERK phosphorylation in EGFR wild-type AD cell lines with high basal LATS2 expression, discriminatory modulation of Akt signaling between EGFR wild-type and mutant cells, and induction of p53 accumulation in AD cell lines with low baseline p53 levels. CONCLUSIONS: LATS2 expression level is predictive of survival in patients with resected lung AD. LATS2 may modulate and contribute to tumor growth via different signaling pathways in EGFR mutant and wild-type tumors.postprin

Immunological Advantages of VATS

第12届全国胸腔镜及胸部微创手术学术研讨会暨第一届国际ATEP会议Section V: Evidence and current status of VAT

Thoracic surgery for complications of tuberculosis in children

Conference Theme: Inspire, Breathe, SleepSession 8: Paediatric Pulmonology - Miscellaneou

A vision for collaborative training in Asia

Training the Next Generation of Thoracic Surgeons in Asi